Cerca risorse accademiche

Tesis de Licenciatura Los tratamientos antiparasitarios de primera línea actualmente disponibles contra la enfermedad de Chagas pueden producir efectos secundarios adversos y no son totalmente efectivos en la etapa cró...

El presente trabajo es una revisión bibliográfica que incluye una revisión inicial de los mecanismos de acción de los diferentes grupos de antifúngicos tanto en lo que respecta a síntesis y función de la membrana ...

En las últimas décadas, importantes avances en la biología molecular y en la tecnología genética subyacente, han provocado un crecimiento inconmensurable en el volumen y variedad de información generada por una vas...

Background: Sodium tungstate is known to be an effective anti-diabetic agent, able to increase beta cell mass in animal models of diabetes, although the molecular mechanisms of this treatment and the genes that control p...

SUMMARY: It is expected that emerging digital gene expression (DGE) technologies will overtake microarray technologies in the near future for many functional genomics applications. One of the fundamental data analysis ta...

BACKGROUND: A more accurate means of prognostication in breast cancer will improve the selection of patients for adjuvant systemic therapy. METHODS: Using microarray analysis to evaluate our previously established 70-gen...

Gene co-expression networks are increasingly used to explore the system-level functionality of genes. The network construction is conceptually straightforward: nodes represent genes and nodes are connected if the corresp...

The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report comp...

Clustering data by identifying a subset of representative examples is important for processing sensory signals and detecting patterns in data. Such "exemplars" can be found by randomly choosing an initial subset of data ...

The Gene Expression Omnibus (GEO, http://www.ncbi.nlm.nih.gov/geo/) is an international public repository for high-throughput microarray and next-generation sequence functional genomic data sets submitted by the research...

Resolving the molecular details of proteome variation in the different tissues and organs of the human body will greatly increase our knowledge of human biology and disease. Here, we present a map of the human tissue pro...

New normal linear modeling strategies are presented for analyzing read counts from RNA-seq experiments. The voom method estimates the mean-variance relationship of the log-counts, generates a precision weight for each ob...

Os últimos vinte anos caracterizaram-se pela proliferação de tecnologias que tornaram possível decifrar o genoma das espécies, localizar e identificar particularidades na sua seqüência, elucidar as suas funções ...

The Hedgehog (Hh) signaling pathway plays critical instructional roles during embryonic development. Misregulation of Hh/Gli signaling is a major causative factor in human congenital disorders and in a variety of cancers...

In this review we provide a systematic analysis of transcriptomic signatures derived from 42 breast cancer gene expression studies, in an effort to identify the most relevant breast cancer biomarkers using a meta-analysi...

In this paper we report exploratory analyses of high-density oligonucleotide array data from the Affymetrix GeneChip system with the objective of improving upon currently used measures of gene expression. Our analyses ma...

Materie / parole chiave: Breast cancer; Medicine; Oncology; Gene signature; Gene expression profiling; Internal medicine; Lymph node; Stage (stratigraphy); Disease; Adjuvant therapy; Metastasis; Microarray

BACKGROUND: In a previous paper, we introduced MUSCLE, a new program for creating multiple alignments of protein sequences, giving a brief summary of the algorithm and showing MUSCLE to achieve the highest scores reporte...

Materie / parole chiave: Gene; Biology; Gene expression; DNA microarray; Breast cancer; Gene expression profiling; Human genome; Cancer research; Cancer; Genetics; Genome

Materie / parole chiave: Biology; Gene; DNA microarray; Gene expression profiling; Gene expression; Oxidative phosphorylation; Genetics; Regulation of gene expression; Computational biology; Biochemistry

BACKGROUND: The quality of automated gene prediction in microbial organisms has improved steadily over the past decade, but there is still room for improvement. Increasing the number of correct identifications, both of g...

BACKGROUND: RNA-Seq is revolutionizing the way transcript abundances are measured. A key challenge in transcript quantification from RNA-Seq data is the handling of reads that map to multiple genes or isoforms. This issu...

MOTIVATION: The processing of the Affymetrix GeneChip data has been a recent focus for data analysts. Alternatives to the original procedure have been proposed and some of these new methods are widely used. RESULTS: The ...

Materie / parole chiave: genomics, nucleic acids, microarray, next-gen sequencing; Science: Biology (General): Genetics