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Tipi di risorsa: Libro cartaceo Libro elettronico Articolo Rivista Tesi Capitolo
Ricerca accademica
Conceptual Integration Theory in Idiom Modifications
Libro elettronico
Libro elettronico
Conceptual Integration Theory in Idiom Modifications
Delibegovic Dzanic, Nihada; Berberovic, Sanja · Publicacions de la Universitat de Valencia · 2019 · ISBN 9788491345565
The long-standing view that idioms are formally and thus also semantically fixed has been challenged and many studies have shown that idioms are indeed flexible both structurally and semantically to varying degrees. We o...
DDC 401.43CDU 81'373.72LCC P325.5.C63Idioma Inglés
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Chemical proteomics reveals sinomenine’s anti-inflammatory mechanism through serum protein covalent modification
Articolo
Articolo
Chemical proteomics reveals sinomenine’s anti-inflammatory mechanism through serum protein covalent modification
Meixian Liu et al · BMC · 2026 · ISSN 1749-8546
Abstract Background Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of ...
LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma Inglés
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Exosomes derived from human umbilical cord mesenchymal stem cells attenuate neuroinflammation in intracerebral hemorrhage rats by modulating lactylation modification
Articolo
Articolo
Exosomes derived from human umbilical cord mesenchymal stem cells attenuate neuroinflammation in intracerebral hemorrhage rats by modulating lactylation modification
Aobo Zhang et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Neuroinflammation following intracerebral hemorrhage (ICH) is a critical contributor to secondary brain injury. Lactylation modification, a novel epigenetic regulatory mechanism, may participate in pa...
LCC LCC:MedicineIdioma Inglés
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Impact of adverse events-associated dose modifications of PARP inhibitors on treatment outcomes in primary ovarian cancer
Articolo
Articolo
Impact of adverse events-associated dose modifications of PARP inhibitors on treatment outcomes in primary ovarian cancer
Yue Fu et al · BMC · 2026 · ISSN 1757-2215
Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPis) are the standard of care for primary ovarian cancer (OC), yet adverse events (AEs) frequently necessitate dose modifications. The prognostic impact of ...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma Inglés
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METTL3 stabilizes FASN mRNA by mediating m6A modification to promote malignant progression of diffuse large B-cell lymphoma
Articolo
Articolo
METTL3 stabilizes FASN mRNA by mediating m6A modification to promote malignant progression of diffuse large B-cell lymphoma
Xiangxiang Song et al · BMC · 2026 · ISSN 2045-3701
Abstract Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma. Fatty acid synthase (FASN) is a key lipogenic enzyme implicated in tumor progression, but its regulation in DLBC...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:Biology (General); TENDOkJpb2NoZW1pc3RyeQ~~Idioma Inglés
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β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
Articolo
Articolo
β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
Dongze Li et al · BMC · 2026 · ISSN 1868-7083
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...
LCC LCC:Medicine; LCC:GeneticsIdioma Inglés
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An early sequential bilingual methodology for three to five-year-old children from public early childhood development centers
Libro elettronico
Libro elettronico
An early sequential bilingual methodology for three to five-year-old children from public early childhood development centers
Durango Isaza, Diana Carolina; Arias Castaño, Enrique; González Marín, Clara Inés · Editorial Universidad Tecnológica de Pereira · 2018 · ISBN 9789587226775
This research emerged from the need of consolidating a meaningful bilingual methodology for children from three- to five-years-of-age from low socioeconomic backgrounds belonging to the public education system, where the...
Idioma Inglés
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Integrated analysis of ATAC-seq and RNA-seq reveals the TCP-ARF molecular module related to pathogenic process of phytoplasma infection in Paulownia fortunei
Articolo
Articolo
Integrated analysis of ATAC-seq and RNA-seq reveals the TCP-ARF molecular module related to pathogenic process of phytoplasma infection in Paulownia fortunei
Shunmou Huang et al · BMC · 2026 · ISSN 1471-2164
Abstract Background Witches’ broom is an important disease of the Paulownia fortunei. Understanding the pathogenesis of witches’ broom is a prerequisite for its prevention and control. Phytoplasma is the pathogen of ...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma Inglés
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Lactylation and acetylation: parallel paths, divergent deeds, and research dilemmas
Articolo
Articolo
Lactylation and acetylation: parallel paths, divergent deeds, and research dilemmas
Wei Jiang et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Metabolism-induced post-translational modifications (PTMs) are critical for the regulation of cellular activities. As important types of modifications, lactylation and acetylation play essential roles...
LCC LCC:MedicineIdioma Inglés
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Nicotine promotes cardiac fibrosis by regulating miR-125b-5p maturation via HNRNPA2B1-mediated METTL14-dependent m⁶A methylation: therapeutic reversal by cinacalcet HCl
Articolo
Articolo
Nicotine promotes cardiac fibrosis by regulating miR-125b-5p maturation via HNRNPA2B1-mediated METTL14-dependent m⁶A methylation: therapeutic reversal by cinacalcet HCl
Hui-hui Wu et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Cardiac fibrosis is a pivotal pathological process driving adverse cardiac remodeling and a defining feature of end-stage heart disease. Nicotine, a principal constituent of tobacco products, is now r...
LCC LCC:MedicineIdioma Inglés
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Regulation of histone methylation on secondary metabolite production in phytopathogenic fungi
Articolo
Articolo
Regulation of histone methylation on secondary metabolite production in phytopathogenic fungi
Xuwen Hou et al · BMC · 2026 · ISSN 2524-4167
Abstract Fungal histone methylation modification (HMM) includes methylation and demethylation at the histone lysine/arginine residues, which are catalyzed by the methyltransferases (HMTs) and demethylases (HDMs) of histo...
LCC TENDOlBsYW50IGN1bHR1cmU~Idioma Inglés
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Unraveling the complexity of the histone code: implications for gene regulation and disease
Articolo
Articolo
Unraveling the complexity of the histone code: implications for gene regulation and disease
Kiera L. Malone et al · BMC · 2026 · ISSN 1474-760X
Abstract Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical ...
LCC LCC:Biology (General); LCC:GeneticsIdioma Inglés
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A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression
Articolo
Articolo
A machine learning-based epigenetic signature reveals YTHDC1 stabilizes POU5F1 to oppose tumor progression
Chen Fang et al · BMC · 2026 · ISSN 1479-5876
Abstract Background The prognosis and progression mechanisms of bladder cancer (BLCA) are highly heterogeneous, driven by complex genetic and epigenetic alterations. This study aimed to construct a robust prognostic sign...
LCC LCC:MedicineIdioma Inglés
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A regulatory network underlying glume hardness revealed by transcriptomic analysis of an ems-induced mutant in synthetic hexaploid wheat
Articolo
Articolo
A regulatory network underlying glume hardness revealed by transcriptomic analysis of an ems-induced mutant in synthetic hexaploid wheat
Xin Liu et al · BMC · 2026 · ISSN 1471-2164
Abstract Background Tenacious glume a key trait limiting threshing efficiency in synthetic hexaploid wheat (SHW), represents an ancestral defense mechanism inherited from wild progenitors. Despite its evolutionary import...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma Inglés
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A review of the circadian regulation of stem cells: harnessing the internal body clock for enhanced regenerative therapies
Articolo
Articolo
A review of the circadian regulation of stem cells: harnessing the internal body clock for enhanced regenerative therapies
Sulaiman Mohammed Alnasser · BMC · 2026 · ISSN 1757-6512
Abstract Background Circadian rhythms are endogenous, transcription-translation feedback loops that align cellular activities with the 24-h light–dark cycle. Stem-cell populations across tissues exhibit circadian oscil...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOkJpb2NoZW1pc3RyeQ~~Idioma Inglés
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ANNalog: generation of MedChem-similar molecules
Articolo
Articolo
ANNalog: generation of MedChem-similar molecules
Wei Dai et al · BMC · 2026 · ISSN 1758-2946
Abstract Generative deep learning models have demonstrated significant potential in designing drug-like molecules. However, medicinal chemistry typically requires generating analogues that combine structural similarity w...
LCC TENDOkluZm9ybWF0aW9uIHRlY2hub2xvZ3k~; TENDOkNoZW1pc3RyeQ~~Idioma Inglés
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Anticancer activity of an apigenin-functionalized silica-coated silver oxide nanocomposite against human gastric adenocarcinoma cells (AGS): in vitro and in silico analysis
Articolo
Articolo
Anticancer activity of an apigenin-functionalized silica-coated silver oxide nanocomposite against human gastric adenocarcinoma cells (AGS): in vitro and in silico analysis
Seyed Milad Mousavi Eshkelani et al · BMC · 2026 · ISSN 1472-6750
Abstract Silver nanoparticles show promise anticancer agents, yet their clinical translation is hindered by poor bioavailability and nonspecific toxicity. In this study, we developed an apigenin-functionalized silica-coa...
LCC TENDOkJpb3RlY2hub2xvZ3k~Idioma Inglés
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Association between sustained opioid use and survival or major adverse cardiovascular events after total knee arthroplasty: evidence from a population-based cohort
Articolo
Articolo
Association between sustained opioid use and survival or major adverse cardiovascular events after total knee arthroplasty: evidence from a population-based cohort
Han-Fang Tseng et al · BMC · 2026 · ISSN 1471-2253
Abstract Objective To examine whether long-term opioid use after total knee arthroplasty (TKA) is associated with subsequent risks of major adverse cardiovascular events (MACE) and all-cause mortality in patients with kn...
LCC LCC:AnesthesiologyIdioma Inglés
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Barriers and facilitators to health promotion behaviours in women with polycystic ovary syndrome and infertility who are actively trying to conceive: a qualitative study using the COM-B model and the Theoretical Domains Framework
Articolo
Articolo
Barriers and facilitators to health promotion behaviours in women with polycystic ovary syndrome and infertility who are actively trying to conceive: a qualitative study using the COM-B model and the Theoretical Domains Framework
Yongjie Tang et al · BMC · 2026 · ISSN 1472-6874
Abstract Background The 2023 International Evidence-based Guideline on polycystic ovary syndrome assessment and management recommends healthcare providers promote healthy lifestyles for all women with polycystic ovary sy...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~; LCC:Public aspects of medicineIdioma Inglés
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Barriers to hypertension management in a developing country: a qualitative study among patients with hypertension at the National Hospital of Sri Lanka
Articolo
Articolo
Barriers to hypertension management in a developing country: a qualitative study among patients with hypertension at the National Hospital of Sri Lanka
Priyanga Ranasinghe et al · BMC · 2026 · ISSN 1471-2458
Abstract Background A rapidly rising prevalence of hypertension (HTN) is observed in low-and-middle-income countries but few studies explore factors such as attitudes and beliefs, experiences and social and cultural cond...
LCC LCC:Public aspects of medicineIdioma Inglés
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Clinical, neuroimaging, and biomarker profiling of four Alzheimer’s disease pedigrees caused by pathogenic APP variants
Articolo
Articolo
Clinical, neuroimaging, and biomarker profiling of four Alzheimer’s disease pedigrees caused by pathogenic APP variants
Jie-Wen Zhang et al · BMC · 2026 · ISSN 1758-9193
Abstract Background Current understanding of the fluid biomarker profile in early-onset Alzheimer’s disease (EOAD) associated with pathogenic APP variants remains limited. We characterized four EOAD pedigrees carrying ...
LCC LCC:Neurosciences. Biological psychiatry. Neuropsychiatry; LCC:Neurology. Diseases of the nervous systemIdioma Inglés
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