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The development of anti-CD3 antibody-based T cell engager therapeutics has improved the treatment of various malignancies, yet the challenge of achieving tumor-specific targeting while minimizing on-target off-tumor effe...

A method development aimed for high-throughput and automated antibody screening holds great potential for areas ranging from fundamental molecular interactions to the discovery of novel disease markers, therapeutic targe...

Human induced pluripotent stem cells (iPSCs) are transforming adoptive cell therapy by combining unlimited self-renewal, broad differentiation potential, and high amenability to genome engineering. These attributes make ...

The development of nanostructured plasmonic biosensors has been widely widespread in the last years, motivated by the potential benefits they can offer in integration, miniaturization, multiplexing opportunities, and enh...

Jiahui Zhang,1– 3,* Junran Tong,1– 3,* Yang Sun,4,* Jinpeng Sun,1– 3 Ran Gao,1– 3 Di Sun,5 Xiaopeng Guo,6 Yumiao Wei1– 3 1Department of Cardiology, Union Hospital, Tongji Medical College...

Biologic therapeutics have transformed the treatment of chronic and life-threatening diseases, yet their clinical use depends almost entirely on parenteral administration. Oral delivery is the preferred route for patient...

Abstract Background The most investigated form of autoimmune-long-QT-syndrome (LQTS) is caused by circulating anti-Ro/SSA(Sjögren’s syndrome-related antigen-A)-52kD antibodies, which cross-react with a specific sequen...

In December, 2019, a local outbreak of pneumonia of initially unknown cause was detected in Wuhan (Hubei, China), and was quickly determined to be caused by a novel coronavirus,1WHOWHO statement regarding cluster of pneu...

Materie / parole chiave: antibody-producing cells, antibody engineering, antibody diagnosis, monoclonal antibodies, immunoregulatory molecules; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Materie / parole chiave: applied biochemistry, computational chemistry and drug discovery, genome engineering, cell engineering, antibody engineering, enzyme engineering; Science: Chemistry: Organic chemistry: Biochemistry; Science: Biology (Gen...

Materie / parole chiave: immunology, antibodies, cancer, antibody therapeutics, antibody engineering; Medicine: Therapeutics. Pharmacology; Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy

Parkinson’s disease (PD) is a nervous disorder, affects physical movement, and leads to difficulty in balancing, walking, and coordination. A novel sensor is mandatory to determine PD and monitor the progress of the tr...

An immunosensor was developed on an interdigitated electrode (IDE) by voltammetry sensing for the early identification of the autoimmune disease ‘rheumatoid arthritis (RA)’ by detecting the biomarker anti-cyclic citr...

Amyloids constitute a class of protein and protein fragments believed to be involved in the pathologies associated with Alzheimer’s, Parkinson’s and Creutzfeldt‐ Jakob diseases. These proteins can self‐assemble i...