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29 risultati trovati.

Tipi di risorsa: Libro cartaceo Libro elettronico Articolo Rivista Tesi Capitolo
Ricerca accademica
fCUT&Tag‐Seq: An optimized CUT&Tag‐based method for high‐resolution profiling of histone modifications and chromatin‐binding proteins in fungi
Articolo
Articolo
fCUT&Tag‐Seq: An optimized CUT&Tag‐based method for high‐resolution profiling of histone modifications and chromatin‐binding proteins in fungi
Haiting Wang et al · Wiley · 2026 · ISSN 2770-100X
Abstract Histone modifications and chromatin‐binding proteins play crucial roles in regulating gene expression in eukaryotes, with significant implications for fungal pathogenicity and development. However, profiling t...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma Inglés
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Heterochromatin and histone modifications in the germline-restricted chromosome of the zebra finch undergoing elimination during spermatogenesis
Articolo
Articolo
Heterochromatin and histone modifications in the germline-restricted chromosome of the zebra finch undergoing elimination during spermatogenesis
Goday, Clara et al · Springer Verlag Berlín · 2010 · ISSN 0009-5915
In the zebra finch (Taeniopygia guttata) a germline-restricted chromosome (GRC) is regularly present in males and females. While the GRC is euchromatic in oocytes, in spermatocytes this chromosome is cytologically seen a...
Idioma Inglés
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An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum
Articolo
Articolo
An integrative analysis of post-translational histone modifications in the marine diatom Phaeodactylum tricornutum
Veluchamy, Alaguraj et al · BioMed Central · 2015 · ISSN 1474-760X
Background: Nucleosomes are the building blocks of chromatin where gene regulation takes place. Chromatin landscapes have been profiled for several species, providing insights into the fundamental mechanisms of chromatin...
Idioma Inglés
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Regulation of chromatin by histone modifications
Articolo
Articolo
Regulation of chromatin by histone modifications
Andrew J. Bannister; Tony Kouzarides · Cell Research · 2011
Materie / parole chiave: Chromatin; Biology; Histone; Histone-modifying enzymes; Chromatin remodeling; Histone code; Computational biology; Cell biology; DNA; ChIA-PET; Genetics; Nucleosome
Idioma Inglés
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The language of covalent histone modifications
Articolo
Articolo
The language of covalent histone modifications
Brian D. Strahl; C. David Allis · Nature · 2000
Materie / parole chiave: Histone code; Nucleosome; Chromatin; Histone; Computational biology; Cell biology; Histone H1; Biology; Epigenomics; Histone methyltransferase; Histone H2A; Histone-modifying enzymes
Idioma Inglés
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Unraveling the complexity of the histone code: implications for gene regulation and disease
Articolo
Articolo
Unraveling the complexity of the histone code: implications for gene regulation and disease
Kiera L. Malone et al · BMC · 2026 · ISSN 1474-760X
Abstract Histone post-translational modifications epigenetically regulate gene expression by modulating nucleosome structure and DNA accessibility. This review outlines how unique patterns of modifications on canonical ...
LCC LCC:Biology (General); LCC:GeneticsIdioma Inglés
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
Articolo
Articolo
Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
Jingyi Yang et al · Springer · 2026 · ISSN 2662-8651
Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...
LCC LCC:MedicineIdioma Inglés
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CUT&Tag for High‐Resolution Epigenomic Profiling From a Low Amount of Arabidopsis Tissue
Articolo
Articolo
CUT&Tag for High‐Resolution Epigenomic Profiling From a Low Amount of Arabidopsis Tissue
Yixuan Fu et al · Wiley · 2026 · ISSN 2475-4455
ABSTRACT Background The genome‐wide profiling of chromatin states that are defined by different histone posttranslational modifications, known as epigenomic profiling, is crucial for understanding the epigenetic regula...
LCC TENDOkJvdGFueQ~~Idioma Inglés
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Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective
Articolo
Articolo
Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective
Fabian M. Cortés-Mancera et al · Frontiers Media S.A · 2026 · ISSN 1664-042X
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...
LCC TENDOlBoeXNpb2xvZ3k~Idioma Inglés
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Epigenetic regulation in cancer metastasis
Articolo
Articolo
Epigenetic regulation in cancer metastasis
Zelong Sun et al · Springer · 2026 · ISSN 2730-6011
Abstract Metastasis is the leading cause of cancer-related deaths. Understanding the molecular mechanism of tumor metastasis is of great significance to cancer research. However, the molecular diagnosis and treatment of ...
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Epigenetics: the master switch of nasopharyngeal carcinoma invasion and metastasis
Articolo
Articolo
Epigenetics: the master switch of nasopharyngeal carcinoma invasion and metastasis
Hongpeng Chen et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Nasopharyngeal carcinoma (NPC) is a metastasis-prone malignancy that is highly prevalent in endemic regions. Epigenetic dysregulation, including aberrant DNA/RNA/protein methylation, histone modifications, and non-coding...
LCC LCC:Immunologic diseases. AllergyIdioma Inglés
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Adenine DNA methylation, 3D genome organization, and gene expression in the parasite Trichomonas vaginalis
Articolo
Articolo
Adenine DNA methylation, 3D genome organization, and gene expression in the parasite Trichomonas vaginalis
Lizarraga, Ayelen et al · National Academy of Sciences · 2020 · ISSN 0027-8424
Trichomonas vaginalis is a common sexually transmitted parasite that colonizes the human urogenital tract causing infections that range from asymptomatic to highly inflammatory. Recent works have highlighted the importan...
Idioma Inglés
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Epigenetics in Alternative Pre-mRNA Splicing
Articolo
Articolo
Epigenetics in Alternative Pre-mRNA Splicing
Luco, Reini F. et al · Cell Press · 2011 · ISSN 0092-8674
Alternative splicing plays critical roles in differentiation, development, and disease and is a major source for protein diversity in higher eukaryotes. Analysis of alternative splicing regulation has traditionally focus...
Idioma Inglés
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Identification and experimental validation of a circular RNA associated with demethylase genes in maize
Articolo
Articolo
Identification and experimental validation of a circular RNA associated with demethylase genes in maize
A. N. Knyazev et al · Federal Agricultural Research Center of the North-East named N.V. Rudnitsky · 2026 · ISSN 2072-9081
In the context of climate change and the need to reduce pesticide and agrochemical use, the development of sustainable crops is becoming increasingly important. Epigenetic mechanisms, such as histone modifications, allow...
LCC LCC:AgricultureIdioma rus
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Stochastic modeling of epigenetic memory
Articolo
Articolo
Stochastic modeling of epigenetic memory
Simone Bruno et al · Nature Portfolio · 2026 · ISSN 2056-7189
Abstract Here, we review mathematical models of epigenetic memory, focusing on chromatin modifications as key mechanisms to achieve long-term maintenance of epigenetic states. After reviewing the main stochastic modeling...
LCC LCC:Biology (General)Idioma Inglés
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The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Articolo
Articolo
The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration
Tanel Punga et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Histone modifications by histone deacetylases (HDACs) are essential for controlling chromatin structure and regulating gene expression. Functionally, HDACs act as enzymatic subunits within diverse multisubunit c...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma Inglés
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Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Articolo
Articolo
Epigenetic Regulations of GABAergic Neurotransmission: Relevance for Neurological Disorders and Epigenetic Therapy
Shikshya Shrestha; Steven M. Offer · Medical Epigenetics · 2016
The GABAergic neurotransmission is a highly conserved system that has been attributed to various regulatory events. There has been a notable number of studies on the importance of GABAergic neurotransmission, both excita...
Idioma Inglés
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β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
Articolo
Articolo
β-Hydroxybutyrate upregulates hepatic histone β-hydroxybutyrylation modification, promotes the expression of PPARα, and alleviates the hepatic steatosis in MASLD
Dongze Li et al · BMC · 2026 · ISSN 1868-7083
Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...
LCC LCC:Medicine; LCC:GeneticsIdioma Inglés
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Hypomyelination and oligodendroglial alterations in a mouse model of autism spectrum disorder
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Articolo
Hypomyelination and oligodendroglial alterations in a mouse model of autism spectrum disorder
Graciarena, Mariana et al · Frontiers Media S.A · 2019 · ISSN 1662-5102
Autism spectrum disorders (ASDs) are neuropsychiatric diseases characterized by impaired social interaction, communication deficits, and repetitive and stereotyped behaviors. ASD etiology is unknown, and both genetic and...
Idioma Inglés
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Multiple tumours of different lineages likely related to a DNMT3A pathogenic R688H variant
Articolo
Articolo
Multiple tumours of different lineages likely related to a DNMT3A pathogenic R688H variant
Hindi Al-Hindi et al · BMJ Publishing Group · 2025 · ISSN 3050-2551
Introduction The relationship between epigenetic modifications that influence gene regulation, such as histone deacetylation, microRNA regulation and DNA methylation, and human diseases has become increasingly recognised...
LCC LCC:GeneticsIdioma Inglés
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PARylation-centric crosstalk: orchestrating immune evasion and multidrug resistance in ovarian cancer
Articolo
Articolo
PARylation-centric crosstalk: orchestrating immune evasion and multidrug resistance in ovarian cancer
Lin Hou et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Post-translational modifications (PTMs) play pivotal roles in ovarian cancer pathogenesis, with poly(ADP-ribosyl)ation (PARylation) serving as a key regulator of DNA repair, immune evasion, and therapeutic resistance. Be...
LCC LCC:Immunologic diseases. AllergyIdioma Inglés
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Signaling pathways associated with interleukins 12 and 23 and epigenetic mechanism of sequential-specific regulation of expression of related genes by miRNAs as molecular markers for assessing the potential of anti-cytokine therapies
Articolo
Articolo
Signaling pathways associated with interleukins 12 and 23 and epigenetic mechanism of sequential-specific regulation of expression of related genes by miRNAs as molecular markers for assessing the potential of anti-cytokine therapies
Beniamin O. Grabarek et al · Termedia Publishing House · 2019 · ISSN 0033-2526
The molecular targeted therapy is focused on blocking the activity of specific cytokines and the signalling cascades they activate. In the treatment of psoriasis, this type of therapy is based on treatment with anti-tumo...
LCC LCC:Medicine; LCC:DermatologyIdioma Inglés
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The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
Articolo
Articolo
The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis
Backe, Marie Balslev et al · Hindawi Publishing Corporation · 2019 · ISSN 2314-6745
Aims. Posttranslational modifications of histones and transcription factors regulate gene expression and are implicated in beta-cell failure and diabetes. We have recently shown that preserving H3K27 and H3K4 methylation...
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The enzymatic mechanisms of lactylation and its role in gynecological diseases: a comprehensive review
Articolo
Articolo
The enzymatic mechanisms of lactylation and its role in gynecological diseases: a comprehensive review
Min Zhang et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Lysine lactylation (Kla) is a novel form of post-translational modification. It utilizes lactate as its core substrate. Through an enzymatic regulatory network, it mediates modifications of both histones and non-histone ...
LCC LCC:Immunologic diseases. AllergyIdioma Inglés
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