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The quantity of physiological data has grown exponentially, yielding insights into mechanisms of phenotypic and disease pathways. Among the powerful tools for physiological omics is the study of RNA, where broad sequenci...

Post-transcriptional control of gene expression allows plants to rapidly adapt to changes in their environment. Under low nitrogen conditions, legume plants engage into a symbiosis with soil bacteria that results in the ...

Abstract Metastasis is the leading cause of cancer-related deaths. Understanding the molecular mechanism of tumor metastasis is of great significance to cancer research. However, the molecular diagnosis and treatment of ...

Long noncoding RNAs (lncRNAs) play key roles in cell processes and are good candi-dates for cancer risk prediction. Few studies have investigated the association between individual genotypes and lncRNA expression. Here w...

Abstract Regulatory T cells (Tregs) are key contributors to maintaining immune system stability, and their impairment has been linked to the pathogenesis of Graves’ disease (GD). However, the precise molecular mechanis...

Long noncoding RNAs (lncRNAs) have emerged as critical regulators of plant development, physiology, and environmental stress adaptation. Despite exhibiting limited primary sequence conservation across the plant kingdom, ...

IntroductionMacrophages play a key role in inflammatory diseases. We aimed to identify long noncoding RNAs that regulate pro-inflammatory activation of human macrophages. MethodsWe performed human lncRNA microarray analy...

PARN regulates poly(A) lengths of pri-miR-29a and pri-miR-1207, which in turn target PARN mRNA. CPSF6 recruits PARN to pri-miRNAs, modulating miRNA levels and cell migration, revealing a dynamic mutual feedback between P...

Precise expression patterns of genes in time and space are essential for proper development of multicellular organisms. Dynamic chromatin conformation and spatial organization of the genome constitute a major step in thi...