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Background: Combining radiotherapy (RT) with immune checkpoint inhibitors (ICIs) offers potential synergy through RT-induced immunogenic cell death and enhanced systemic immunity. However, optimal RT dose, fractionation,...

Abstract With the advent of the immunotherapy era, the combination of radiotherapy and immunotherapy has become a critical strategy to enhance patient outcomes. In addition to its direct cytotoxicity, radiotherapy modula...

Zi-Hong Li,* Jia-Xing Guo,* Ji-Hong Zhang, Zhi-Ling An, Xiao Liang, Li-Hua Wang, Ying-Na Bao Department of Radiotherapy, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, 010050, Peopl...

Combined radiotherapy and chemotherapy remain central to cancer treatment, with metallodrugs – most notably platinum agents – playing indispensable roles in clinical regimens. However, systemic toxicity and limit...

Abstract Background Locally advanced non-small cell lung cancer (LA-NSCLC) with spinal invasion presents a rare but challenging clinical scenario. Radical surgical approaches, though potentially curative, are often not f...

BACKGROUND: Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by a...

Abstract Background Stereotactic radiotherapy (SRT) is an emerging treatment for sinonasal tumors in dogs. Reported results regarding tumor control and incidence of acute and late radiation morbidities are inconsistent. ...

Background and purpose: Deviations in radiotherapy quality can significantly affect clinical trial outcomes, including overall survival. Radiotherapy quality assurance (RTQA) is a systematic process by which a RT plan is...

Abstract Purpose Patients with nasopharyngeal carcinoma (NPC) exhibiting persistent EBV DNA positivity throughout treatment (a “D-D-D” trajectory) represent a high-risk group with undefined management strategies. Thi...

BackgroundSolid pseudopapillary tumors (SPTs) of the pancreas are rare, low-grade malignancies that generally have favorable outcomes when diagnosed at an early stage and can be resected. However, treatment options for p...

Background and purposeRadiotherapy (RT) often causes delayed radiation-induced brain injury (RBI) with unclear pathophysiology; emerging evidence links this to glymphatic dysfunction, but radiation effects on cerebrospin...

Background and Purpose: Anatomical variations during prostate radiotherapy can cause discrepancies between planned and delivered doses, which may become more pronounced in (ultra-)hypofractionated regimens. However, a st...

Abstract Background Cancer treatments such as chemotherapy and radiotherapy significantly impact the cardiovascular system. While cardiac toxicity is well characterized, the effects on the aorta, the body’s largest art...

BackgroundThe systemic immune-inflammation index (SII) has emerged as a widely studied inflammatory biomarker reflecting the balance between host inflammatory and immune status, although evidence in lung cancer patients ...

Background and Purpose: Deep learning segmentation (DLS) and planning (DLP) models in radiotherapy treatment planning increase consistency and reduce planning time. However, many DL segmentations and plans are manually a...

Background and purpose: Image-guided radiotherapy (IGRT) for esophageal cancer requires large planning target volume (PTV) margins to account for interfraction variations, increasing radiation-associated side-effects. Co...

ABSTRACT Purpose: The combination of radiotherapy and immunotherapy (radioimmunotherapy) shows promising antitumor efficacy but raises cardiotoxicity concerns. The underlying mechanisms remain unclear. Methods: Preclinic...

Background and purpose: Stereotactic radiotherapy (SRT) delivers high doses with submillimeter precision to small targets, requiring accuracy in both dose calculation and delivery. This study aimed to perform a dosimetri...

IntroductionHead and neck cancer (HNC) is a major global health issue, often linked to smoking, alcohol, and viruses (HPV, EBV). HPV-driven oropharyngeal squamous cell carcinoma (OPSCC) showed distinct biology and better...

Abstract Background and aims Radiotherapy, like chemotherapy, in breast cancer can cause cardiotoxicity. Research about the combined effect of radiotherapy and chemotherapy on left ventricular diastolic function (LVDD) i...

Objective: To assess the efficacy and safety of Qixuekang oral liquid in the treatment of leukopenia during chemotherapy and radiotherapy. Methods: This randomized, double-blind, placebo-controlled, multicenter clinical ...

Abstract Objective To systematically evaluate the efficacy differences between stereotactic radiosurgery (SRS) and whole-brain radiotherapy (WBRT) in treating brain metastases from small cell lung cancer (SCLC), and to a...

Background: Due to the close approximation of testis to radiotherapy treatment field in male carcinoma rectum patients, it receives either scattered or direct radiation. The present study aimed to investigate the impact ...

Abstract Objective: A combination of chemotherapy and pelvic radiotherapy is recommended to treat locally advanced cervical cancer (CC), which has been associated with acute and chronic toxicities, especially radiation ...