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Type 2 diabetes mellitus (T2DM) is characterized by chronic metabolic dysfunction and low-grade inflammation. This study aimed to identify inflammation-associated molecular targets in T2DM and to computationally evaluate...

Abstract Background Inflammatory bowel disease (IBD) represents a group of chronic and relapsing inflammatory disorders of the gastrointestinal tract, primarily encompassing Crohn’s disease (CD) and ulcerative colitis ...

The rise of single-cell transcriptomics and comprehensive reference atlases promised a unifying molecular framework to classify cell identity. Yet transcriptomic identities are often interpreted outside the environmental...

Background: Cardiac complications arising from diabetes mellitus manifest as structural and functional myocardial alterations independent of traditional cardiovascular risk factors. The intricate molecular underpinnings ...

Abstract HER2-positive breast cancer exhibits marked genomic instability and heterogeneity, yet the clonal architecture and copy number variation (CNV) dynamics between ductal carcinoma in situ (DCIS) and invasive ductal...

Abstract Background Sodium overload-induced cell death is a novel mode of cell death that differs from other modes and is a very promising new target for cancer therapy. In addition, sodium overload-induced cell death pl...

Abstract Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA expression in livi...

Abstract Understanding the composition of the tumor microenvironment is critical for cancer research. Spatial transcriptomics profiles gene expressions in spatial context, revealing tissue architecture and cellular heter...

Si-Hang Wang,1 Si-Zhe Li,1 Yi-Ran Li,2 Jie Zhang,1 Yan Wang,1 Ya-Gang Zuo1 1Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of M...

Chronic norovirus infection (CNI) causes significant morbidity and mortality in immunocompromised patients, including those with inborn errors of immunity (IEI). Gastrointestinal samples from patients with CNI demonstrat...

ABSTRACT A systems biology approach was used to characterize Monotropa uniflora, a nonhotosynthetic, myco‐heterotrophic plant. In contrast to autotrophic plants, myco‐heterotrophic plants obtain carbon and other nutr...

Abstract Background Viral infections of tomato plants present a significant threat to tomato production and yield. Mixed viral infections are common in field-grown tomatoes and are known to exacerbate disease symptoms; h...

Abstract Tumor-associated B (TAB) cells and plasma cells are increasingly recognized as key components of the tumor microenvironment; however, their heterogeneity and functional roles in breast cancer remain incompletely...

Background: Sodium tungstate is known to be an effective anti-diabetic agent, able to increase beta cell mass in animal models of diabetes, although the molecular mechanisms of this treatment and the genes that control p...

Materie / parole chiave: RNA-Seq; Biology; Transcriptome; Computational biology; RNA; DNA sequencing; Deep sequencing; De novo transcriptome assembly; Genetics; Gene; Genome; Gene expression

Abstract Background Venom cocktails of cone snails are characterized by their dynamic composition and the rapid evolution of toxin-encoding genes due to various selective pressures. The integration of comparative genomic...

Abstract With rapid advances in meat science in recent decades, changes in meat quality during the pre-slaughter phase of muscle growth and the post-slaughter process from muscle to meat have been investigated. Commonly ...

The quantity of physiological data has grown exponentially, yielding insights into mechanisms of phenotypic and disease pathways. Among the powerful tools for physiological omics is the study of RNA, where broad sequenci...

Abstract Background The efficient bioconversion of lignocellulosic hydrolysates to xylitol is hampered by inhibitors such as acetic acid and furfural. This study investigated the response mechanisms of two engineered xyl...

Kexin Ma, Jinqiao Tian, Hao Wu, Shuzheng Wang, Hao-Sheng Ni Department of Otolaryngology, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, People’s Republic of ChinaCor...

Abstract Stem cell-derived RPE replacement is a potential therapeutic for advanced AMD that is characterized by macular scarring and geographic atrophy leading to severe vision loss. Although the field of stem cell-diffe...

Identifying meaningful patterns in data is crucial for understanding complex biological processes, particularly in transcriptomics, where genes with correlated expression often share functions or contribute to disease me...

Abstract Virtual staining technology offers a promising solution to overcome the time-consuming and sample-consumption nature of conventional histochemical staining in breast cancer pathology. This study presents a novel...