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The cooperative and collaborative work between Universities and Libraries are key points for teachers, researchers and students to make progress in their studies and research. The Library Linkage Initiative has pursued t...

Object-oriented software development has proven effective for systems development, but the creation of reusable and changeable software architectures is still a challenging task. Design patterns capture the expertise for...

In situ hybridization (ISH) method allows to reveal specific genes expression, identify specific cell types and detect areas or tissues, displaying differential gene expression. This work describes a standardized procedu...

The resolution of optimization problems is of great interest nowadays and has encouraged the development of various information technology methods to attempt solving them. There are several problems related to Software E...

This thesis is based on a certain type of legacy software that came from scientific research. Scientists have become one of the most important legacy code producers for many reasons. One of these is long-lived field (abo...

The use of generic and generative methods for the development and application of interactive educational software is a relatively unexplored area in industry and education. Advantages of generic and generative techniques...

"Electroencephalography (EEG) system validation faces a fundamental challenge: the absence of ground truth when measuring human subjects. Physical head phantoms provide controlled testing environments with known signals;...

Many methodologies have been proposed to systematize the software development process. Many of them have been widely adopted. However, the majority has focused on analysis and design. Requirements have frequently been fo...

In this paper we describe a methodology to translate BON (architectural) designs to Alloy specifications. The main virtue of this process is that it can be implemented by means of software tools. The utilization of this ...

Structural equation modeling (SEM) is a vast field and widely used by many applied researchers in the social and behavioral sciences. Over the years, many software packages for structural equation modeling have been deve...

Macromolecular X-ray crystallography is routinely applied to understand biological processes at a molecular level. However, significant time and effort are still required to solve and complete many of these structures be...

An account is given of the development of the SHELX system of computer programs from SHELX-76 to the present day. In addition to identifying useful innovations that have come into general use through their implementation...

Abstract Motivation: Robust large-scale sequence analysis is a major challenge in modern genomic science, where biologists are frequently trying to characterize many millions of sequences. Here, we describe a new Java-ba...

MOTIVATION: A new protocol for sequencing the messenger RNA in a cell, known as RNA-Seq, generates millions of short sequence fragments in a single run. These fragments, or 'reads', can be used to measure levels of gene ...

BACKGROUND: Correlation networks are increasingly being used in bioinformatics applications. For example, weighted gene co-expression network analysis is a systems biology method for describing the correlation patterns a...