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The Breast Health Global Initiative (BHGI) applied an evidence-based consensus review process to develop guidelines for breast cancer early detection, diagnosis, and treatment in low- and middle-income countries (LMCs) i...

In this paper the changing process undergone by the State regarding its influence on the economy is analyzed. In this sense, there are positions that focus their analyses in the reduction of the dimensions of the State a...

Benjamini and Hochberg suggest that the false discovery rate may be the appropriate error rate to control in many applied multiple testing problems. A simple procedure was given there as an FDR controlling procedure for ...

Materias / palabras clave: Biology; Gene; Pairing; Genetics; microRNA; Computational biology; Quantum mechanics; Superconductivity; Physics

SUMMARY The common approach to the multiplicity problem calls for controlling the familywise error rate (FWER). This approach, though, has faults, and we point out a few. A different approach to problems of multiple sign...

Materias / palabras clave: Amplicon; Computational biology; Biology; Sample (material); Computer science; Genetics; Polymerase chain reaction; Gene; Chromatography; Chemistry

Materias / palabras clave: Mendelian randomization; Pleiotropy; Biology; Genetics; Trait; Mendelian inheritance; Outlier; Evolutionary biology; Statistics; Phenotype; Mathematics; Genetic variants

Materias / palabras clave: Biology; Ruminococcus; Microbiome; Bacteroides; Firmicutes; Gut flora; Microorganism; Roseburia; Microbial ecology; Microbiology; Food science; Bacteria

BACKGROUND: Usually the researchers performing meta-analysis of continuous outcomes from clinical trials need their mean value and the variance (or standard deviation) in order to pool data. However, sometimes the publis...

Materias / palabras clave: Bottleneck; Metagenomics; Computer science; Diamond; Sensitivity (control systems); Software; Search engine indexing; Speedup; Computational biology; Data mining; Bioinformatics; Parallel computing

Maximum likelihood or restricted maximum likelihood (REML) estimates of the parameters in linear mixed-effects models can be determined using the lmer function in the lme4 package for R. As for most model-fitting functio...

Although genomewide RNA expression analysis has become a routine tool in biomedical research, extracting biological insight from such information remains a major challenge. Here, we describe a powerful analytical method ...

Materias / palabras clave: Generalized linear mixed model; Inference; Statistical inference; Computer science; Ecology; Evolutionary ecology; Econometrics; Mathematics; Statistics; Machine learning; Artificial intelligence; Biology

Materias / palabras clave: Medicine; Stroke (engine); Heart disease; Association (psychology); Cardiology; Disease; Internal medicine; Mechanical engineering; Engineering; Epistemology; Philosophy

Materias / palabras clave: Medicine; Stroke (engine); Association (psychology); Disease; Heart disease; Cardiology; Internal medicine; Epistemology; Philosophy; Mechanical engineering; Engineering

BACKGROUND: The American Heart Association, in conjunction with the National Institutes of Health, annually reports on the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors, inc...

The cBioPortal for Cancer Genomics (http://cbioportal.org) provides a Web resource for exploring, visualizing, and analyzing multidimensional cancer genomics data. The portal reduces molecular profiling data from cancer ...

Materias / palabras clave: microRNA; Biology; Gene expression profiling; Computational biology; RNA; Messenger RNA; Gene expression; Genetics; Gene; Bioinformatics

Materias / palabras clave: Linkage (software); Genetic association; Genome-wide association study; Association (psychology); Set (abstract data type); Genetics; Population; Biology; Computational biology; Association mapping; Evolutionary biology;...

Saturation has attained widespread acceptance as a methodological principle in qualitative research. It is commonly taken to indicate that, on the basis of the data that have been collected or analysed hitherto, further ...

The cBio Cancer Genomics Portal (http://cbioportal.org) is an open-access resource for interactive exploration of multidimensional cancer genomics data sets, currently providing access to data from more than 5,000 tumor ...

Introduction - Norman K Denzin and Yvonna S Lincoln The Discipline and Practice of Qualitative Research PART ONE: LOCATING THE FIELD Qualitative Methods - Arthur J Vidich and Stanford M Lyman Their History in Sociology a...