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A series of 7-chloro-3-(2-substituted phenyl-4-oxo-thiazolidin-3-yl)-2-[2-(2,6-dichlorophenyl) amino]benzyl-quinazolin-4(3H)-ones (5a-j) have been synthesized and characterized by elemental analyses as well as IR and NMR...

The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan...

The objective of the present investigation was to evaluate the potential of gellan gum- low molecular weight chitosan (GG-LMCH) polyelectrolyte complex (PEC) in the form of beads as prolonged release stomach specific flo...

Acorus calamus (Araceae) is commonly known in India as sweet flag and has been used in traditional medicine as a remedy for pain, convulsion, inflammation, and ulcer. In the present work, the methanolic extract of Acor...

Materias / palabras clave: Computer science; Visualization; Workstation; Software; Context (archaeology); Interface (matter); Rapid prototyping; Segmentation; Focus (optics); Medical imaging; Graphical user interface; Human–computer interaction

Unlike other methods for docking ligands to the rigid 3D structure of a known protein receptor, Glide approximates a complete systematic search of the conformational, orientational, and positional space of the docked lig...

Information theory provides a constructive criterion for setting up probability distributions on the basis of partial knowledge, and leads to a type of statistical inference which is called the maximum-entropy estimate. ...

Materias / palabras clave: Computer science; Internet of Things; The Internet; Multimedia; World Wide Web; Human–computer interaction; Computer security; Internet privacy

The present investigation concerns the development of mucoadhesive tablets of captopril which were designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated u...

Metformin hydrochloride (MH), an important drug in the treatment of type II diabetes mellitus, requires multiple administration in 500-1500 mg doses/day. Sustained release gastro retentive multiparticulates of MH were pr...

Rifabutin loaded floating gellan gum beads were prepared by Ca++ induced ionotropic gelation in acidic medium by drop wise addition of gellan gum dispersion containing drug and gas-generating agent. The prepared beads we...

The objective of present study was to improve gastric residence time of furazolidone by preparing mucoadhesive Multiple Unit Systems (MUS) with chitosan, Hydroxypropyl methyl cellulose K4M and sodium carboxymethyl cellul...

The objective of this study was to enhance the anti-inflammatory activity of quercetin through complexation, by kneading method, with β cyclodextrin (βCD), hydroxy propyl β cyclodextrin (HP-βCD), and sulpha butyl eth...

The purpose of the present investigation was to prepare gellan-chitosan polyelectrolyte complex beads in one step and to explore the potential of the prepared beads in the oral delivery of metronidazole (log P = 0.0) and...

The objective of the present study was to investigate the applicability of matrix type chitosan treated alginate multiple unit systems (MUS) for sustained release of metronidazole prepared by ionotropic gelation method. ...

Cylin dependent kinases (CDKs) have emerged as novel mechanistic target due to their direct involvement in underlying genetic changes during the cancerous state. In order to identify the essential physiochemical paramete...

A series of some novel thiazolidinones derivatives were synthesized and evaluated for their pharmacological activities. Thiazolidinones were synthesized from p-nitro aniline in four steps. First Schiff’s bases (V1- 8) ...

Type II fatty acid synthesis (FAS II) pathway has been recently reported as an attractive targeting for their efficacy against infections caused by multi-resistant Gram-positive and Gram-negative bacteria. Among the rela...