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"...chitosan has proved to be versatile for so many industrial applications and its versatility is the main value of this polymer. However, the lability at acidic pH of chitosan is a limiting factor that affects mainly ...

In the present study, we sought to systemically evaluate the biodistribution and the tumor-accumulation of N-succinyl-chitosan nanoparticles (Suc-Chi-NPs, 200 nm in diameter) in model tumor-bearing mice and also the bind...

Chitosan is increasingly used as an alternative to synthetic polymers due to its water solubility, biodegradability, and biological activity. In this work, chitosan samples from three suppliers were evaluated and charact...

The present study involves the preparation of nimesulide-chitosan microparticles (NCM) as sustained delivery carriers with different polymer concentrations by pH change coacervation method using glutaraldehyde as cross-l...

The aim of this study was to develop sustained release formulation for improving bioavailability of metronidazole designing metronidazole loaded chitosan microcapsules (MLCM) using coacervation technique. Two solutions w...

Didanosine (ddI) is an important drug in the AIDS therapy. However, to overcome the instability of ddI in acid medium, the tablets have a large amount of buffer that can lead to side effects such as diarrhea and kidney p...

Polymeric membranes have been used as wound dressings for burns and healing wounds. Healing properties, anti-inflammatory and antibiotic in such membranes can be induced and/or made possible with the incorporation of bio...

The purpose of the present investigation is to study the effect of incorporation of gelucire 39/01 and 50/13 on encapsulation efficiency and release of water soluble drug (metronidazole, log P = 0.0) from floating gellan...

The purpose of this study was to investigate the impregnation of chitosan microspheres with the natural dye curcuma. The impregnation with curcuma dye was investigated in aqueous medium at pH 9.0, 9.5 and 10.0. The proce...

The objective of the present investigation was to evaluate the potential of gellan gum- low molecular weight chitosan (GG-LMCH) polyelectrolyte complex (PEC) in the form of beads as prolonged release stomach specific flo...

The purpose of the present investigation was to prepare gellan-chitosan polyelectrolyte complex beads in one step and to explore the potential of the prepared beads in the oral delivery of metronidazole (log P = 0.0) and...

A novel polymer, chemically modified chitosan was synthesized by reacting with hydrochloride salt of 2-aminoethanoyl chloride. Formation of novel chemically modified chitosan was confirmed by FTIR and NMR spectroscopy an...

Oral route of drug administration is the most preferred route of drug administration but this route has its own limitations like pH of gastric media and controlling release rate of water soluble drug. To overcome these l...

"This work described the preparation and characterization of water insoluble chitosan derivatives as lead adsorbents. In highly regioselective reactions, N-substituted crosslinked chitosan derivatives were obtained by cr...

"A rapid and sensitive analytical method for the trace determination of aflatoxin M1 in domestic waters was developed using chitosan as a sorbent and HPLC with fluorescence detection (HPLC-FLD). Computational simulations...

Nimesulide was formulated as novel dual coated microparticles using chitosan (CTN) and ethyl cellulose (EC) as encapsulating materials for its improved delivery to the intestine and to prevent gastric irritation and incr...

La formación de coacervados complejos entre quitosana y alginato fue evaluada durante la formación de micropartículas. La proporción de masa entre polielectrolitos y concentración de cloruro de calcio fue determinad...

The purpose of the present research work was to produce a biphasic delivery system for Diclofenac sodium. A dual component tablet made up of a sustained release beads and immediate release tablet coat was prepared by dir...

The objective of present study was to improve gastric residence time of furazolidone by preparing mucoadhesive Multiple Unit Systems (MUS) with chitosan, Hydroxypropyl methyl cellulose K4M and sodium carboxymethyl cellul...

El trabajo describe un sistema de dispositivo de liberacíon lenta de droga de una película de quitosano cargada de tetraciclina con efecto antibiótico sostenido. Las películas de quitosano (CF) que contenían tetraci...

The objective of the present study was to investigate the applicability of matrix type chitosan treated alginate multiple unit systems (MUS) for sustained release of metronidazole prepared by ionotropic gelation method. ...

El objetivo de este estudio fue preparar sistemas multiparticulados de pectina: quitosano (PC:CS) y evaluar el comportamiento del hinchamiento y la liberación de la droga en diversos ambientes. Las partículas de PC:CS ...

The purpose of this work was to design and evaluate a novel vaginal delivery system for the local treatment of vaginal candidiasis. Bioadhesive vaginal films of metronidazole that could be retained in the vagina for prol...

Novel stable mucoadhesive chitosan microspheres were developed to explore the possibility of nasal delivery of L-dopa to avoid first pass metabolism and to improve therapeutic efficiency in treating the symptoms of parki...