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Homology modelling has matured into an important technique in structural biology, significantly contributing to narrowing the gap between known protein sequences and experimentally determined structures. Fully automated ...

Motivated by Khovanov homology and relations between the Jones polynomial and graph polynomials, we construct a homology theory for embedded graphs from which the chromatic polynomial can be recovered as the Euler charac...

We have developed a simple and highly efficient method to disrupt chromosomal genes in Escherichia coli in which PCR primers provide the homology to the targeted gene(s). In this procedure, recombination requires the pha...

Materias / palabras clave: Similarity (geometry); Amino acid; Homology (biology); Sequence (biology); TRACE (psycholinguistics); Mathematics; Computational biology; Computer science; Algorithm; Biology; Genetics; Artificial intelligence

Materias / palabras clave: CRISPR; Genome engineering; Cas9; Genome editing; Guide RNA; Biology; Computational biology; Nuclease; Genome; Homology directed repair; Synthetic biology; Non-homologous end joining

Se propone un método particular para seleccionar, de los nombres ya existentes, el más apropiado para cada músculo, y un método general para escoger los nombres apropiados de las estructuras anatómicas. Estos nombre...

ColabFold offers accelerated prediction of protein structures and complexes by combining the fast homology search of MMseqs2 with AlphaFold2 or RoseTTAFold. ColabFold's 40-60-fold faster search and optimized model utiliz...

Functional elucidation of causal genetic variants and elements requires precise genome editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune ...