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Simultaneous multiple prescription drugs increases the possibility of drug interactions, situation particularly critical in a hospital. The objective of the present work was to identify interactions by evaluating the ori...

The aim of this work was to study of the use of injectable antibiotics in patients admitted to the National Clinical Hospital (Córdoba-Argentina). To carry out this purpose, data of antimicrobial consumption were survey...

Surflex-dock method was explored to study interactions between Qingxuanjiangya decoction (QXJYD in abbreviation, a famous hypotensive herb formula from Traditional Chinese Medicine prescription) and Peroxisome proliferat...

Substrate-dependent inhibition of CYP3A4 might influence the extrapolation of drug interactions from the in vitro to in vivo situation. The aim of the present study is to investigate reversible and time-dependent inhibit...

Based on van't Hoff and Gibbs equations, thermodynamic functions Gibbs energy, enthalpy, and entropy of solution, mixing and solvation of ibuprofen in water at pH 1.2 and 6.8, were evaluated from solubility values determ...

Information processing in the cerebral cortex involves interactions among distributed areas. Anatomical connectivity suggests that certain areas form local hierarchical relations such as within the visual system. Other c...

There are considerable number of approaches to policy specification both for security management and policy driven network management purposes as reported in [20]. This specification sort security policies into two basic...

A simple isocratic method for quantification of hydroxyzine dihydrochloride by HPLC with UV detection at 232 nm in syrup has been developed and validated. Separation was achieved on a C18 column (250 x 4.6 mm, 5 μm) mai...

Hydroquinone (HQ) is a drug reported to possess manifold biological activities. HQ is highly unstable into various topical vehicles, presenting low topical bioavailability and a relevant level of toxicity. The Pluronic®...

In this paper, a trajectory tracking control for a nonholonomic mobile robot subjected to uncertainties and disturbances in the kinematic model is proposed. An adaptive variable structure controller based on the sliding ...

Several species of the Polygonum genera are collectively known in Brazil under the name "erva-de-bicho". In tradicional medicine, these species often mistaken for each other and are probably used for the same therapeutic...

D-002, a mixture of six beeswax alcohols, with gastroprotective and anti-inflammatory effects, was compared with naproxen, aspirin and their combined therapy in rats with cotton pellet granuloma. After pellet implantatio...

Manilkara subsericea (Mart.) Dubard (Sapotaceae) is popularly known in Brazil as "guracica". The species from the genus Manilkara have been studied and several substances were found, including triterpenes. In the present...

The methanol extract of the whole plant of Eclipta prostrata and one of its isolated compounds, eclalbasaponin II were administered to alloxan-induced diabetic rats for 28 and 7 consecutive days, respectively. During the...

The aim of this study was to investigate the impact of solid dispersions of polyethylene glycol 6000 (PEG 6000), using the co-precipitation method, on the in vitro solubility and intestinal absorption of praziquantel (PZ...

The aim of this study was to evaluate the in vivo behavior of matrix tablets formulated with ketoprofen as a model drug after oral administrations in healthy Malaysian male volunteers and to compare its rate and extent o...

The protective role of n-BuOH extract of Potentilla anserina roots was measured by MTT method and colorimetric method on human umbilical vein endothelial cells (EAhy926) under hypoxia injury. The extract tested (3 mg/mL,...

Un león de montaña (Felis concolor), macho de 23 años de edad Montaña desarrollo una claudicación crónica en el parque zoológico “El Pinar”, Caracas-Venezuela. Se le practico eutanasia. Macroscópicamente, la ...

Los programas de pensiones latinoamericanos tienen baja cobertura. Utilizando paneles de registros administrativos de Argentina, Chile y Uruguay, caracterizamos las historias de contribución de la población. Construimo...

The present study was designed to investigate the effects of curcumin, a natural product derived from turmeric of the herb Curcuma longa, on proliferation, metastasis of FaDu cells, and the relevant mechanisms. Results s...

The present investigation concerns the development of floating tablets of tramadol hydrochloride, which after oral administration are designed to prolong the gastric residence time; improves the drug bioavailability, red...

The aim of the current study was the design, development and optimization of oral immediate release solid dosage forms of gliclazide tablets, intended for rapid action within 30 min, formulated and optimized by in vitro ...

A sensitive and selective liquid chromatography-mass spectrometry (LC-MS) method for determination of ibudilast in rabbit plasma was developed and validated. After addition of estazolam as internal standard (IS), protein...

A sensitive and simple liquid chromatography/electrospray mass spectrometry (LC-ESI-MS) method for determination of ketamine in rabbit plasma using one-step protein precipitation was developed and validated. After additi...