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The objective of the present study was to develop an oral timed-released press-coated tablet containing theophylline as a model drug. A D-optimal design of experiment was employed to systematically study the effect of te...

Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalizability. The Strengthening the Reporti...

Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability. The Strengthening the Reporti...

Much biomedical research is observational. The reporting of such research is often inadequate, which hampers the assessment of its strengths and weaknesses and of a study's generalisability. The Strengthening the Reporti...

BACKGROUND: Scoping studies are an increasingly popular approach to reviewing health research evidence. In 2005, Arksey and O'Malley published the first methodological framework for conducting scoping studies. While this...

BACKGROUND: There is a growing recognition of the value of synthesising qualitative research in the evidence base in order to facilitate effective and appropriate health care. In response to this, methods for undertaking...

For any given research area, one cannot tell how many studies have been con-ducted but never reported. The extreme view of the "file drawer problem " is that journals are filled with the 5 % of the stud...