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Craniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation...

In the growing diversity of human induced pluripotent stem cell (iPSC)-derived models of brain development, we present here a novel method that exhibits 3D cortical layer formation in a reproducible topography of minimal...

Abstract Mutations in the CYFIP2 gene, particularly the R87C variant, are associated with severe epileptic encephalopathy, and present challenges for therapeutic development. This study utilized CRISPR/Cas9-edited human ...

The identification of suitable models for predicting daily water flow is important for planning and management of water storage in reservoirs of Argentina. Long-term prediction of water flow is crucial for regulating res...

The prediction and design of photonic features have traditionally been guided by theory-driven computational methods, spanning a wide range of direct solvers and optimization techniques. Motivated by enormous advances in...

Abstract The accurate prediction of the deterioration of Continuously Reinforced Concrete Pavement (CRCP) is essential for the effective management of pavements and the maintenance of infrastructure. In this study, a co...

The need for early and precise identification of abnormalities has made the detection and classification of brain tumours essential components of medical diagnosis. Because brain tumours are naturally complex and can hav...

Abstract Graph neural networks (GNNs) are widely used as surrogates for costly experiments and first-principles simulations to study the behavior of compounds at atomistic scale, and their architectural complexity is con...

Reading fluency depends on rapid integration of print and speech, yet the spatiotemporal mechanisms supporting this integration in school aged children remain poorly understood. This study combined fMRI and EEG to examin...

ABSTRACT With the development of unmanned aerial vehicle and satellite technology, the application of tiny object detection in remote sensing images is becoming increasingly widespread. Although significant progress has ...

The foremost task in agriculture is the decisive identification of citrus plants and the timely identification of diseases in the plants with the aim of improving the quality of crops and the yield. In this work, a machi...

Perinatal asphyxia (PA) is a primary cause of neonatal morbidity, with persistent neurological sequelae, associated with mitochondrial dysfunction and redox imbalance. The lack of experimental approaches for region-speci...

Abstract The rapid development of China’s financial markets, particularly the expansion of the ETF ecosystem, has made dynamic sector rotation strategies increasingly feasible and cost-effective for investors. At the s...

The rapid proliferation of unmanned aerial vehicles (UAVs) has created an urgent need for robust detection & identification systems to ensure airspace security and safety. However, the scarcity of large-scale, div...

Abstract Squeeze casting (SC) is an advanced net manufacturing process with many advantages for which the quality and properties of the manufactured parts depend strongly on the process parameters. Unfortunately, a unive...

Over the past decade, mobile devices have become an integral part of our daily routines, offering a broad spectrum of applications that enhance everyday tasks. As more people adopt smartphones, developers are increasingl...

Abstract Pheochromocytomasand paragangliomas (collectively referred as PPGLs) are highly heritable neoplasms arise from chromaffin cells of neural crest tissues; 40% of patients with PPGLs harbour germline pathogenic var...

Malware represents the most critical threat in cybersecurity, meant to compromise the security for any individual or any organization. These are covert software, designed to perform malicious act like data theft, data al...

Abstract Stem cell-derived RPE replacement is a potential therapeutic for advanced AMD that is characterized by macular scarring and geographic atrophy leading to severe vision loss. Although the field of stem cell-diffe...

The invasive brain-computer interface (BCI) is a method that involves implanting microelectrodes into brain tissue to collect neural electrical signals. The signals obtained through this method are often of high precisio...

Leaf-cutter ants play a crucial role in agroecosystems, and understanding their behavior is key to developing effective damage control strategies. While several tracking solutions exist for ants in controlled environment...

ABSTRACT Background and Aims De novo drug design is the process of generating novel lead compounds that possess desirable pharmacological activities and optimal physicochemical properties for therapeutic development. In ...

Objective: To identify risk factors for post-radiation xerostomia and to evaluate the tolerance to doses administered to the parotid gland in patients with nasopharyngeal carcinoma (NPC). Methods: A total of 462 patients...

Abstract The molecular control and ancestral state of dorsal–ventral patterning within spiralians remain unclear due to the remarkable diversity across species. Here we present a chromosome-level genome for the brachio...