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HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis. HELIOS shares a conserved N-terminal DNA-binding and C-terminal...

ABSTRACT Background and Aims Familial Mediterranean Fever (FMF) is a monogenic autoinflammatory disease caused by mutations in the MEFV gene, resulting in recurrent inflammatory episodes and a risk of developing amyloido...

Immune dysregulation can lead to autoimmunity and autoinflammation. The goal of treatment is to balance targeted therapies while avoiding infections or other side effects, which becomes complicated with multiple diagnose...

C1q nephropathy is a rare cause of idiopathic nephrotic syndrome seen in children and young adults. Mesangial proliferation with deposition of C1q in the mesangium on immunofluorescence examination is the main pathologic...

C1q nephropathy is a rare cause of idiopathic nephrotic syndrome seen in children and young adults. Mesangial proliferation with deposition of C1q in the mesangium on immunofluorescence examination is the main pathologic...

Abstract Background Pediatric connective tissue disease-associated interstitial lung disease (CTD-ILD) is a rare but serious condition with limited clinical data; this study aimed to evaluate its clinical features, treat...

Antimalarial drugs used in medicine for over 300 years, nowadays, due to their anti-inflammatory, immunomodulatory and antiproliferative photoprotective properties, are used in the therapy of many dermatologic and rheuma...

Grey wolves (Canis lupus) rely on olfaction to communicate and acquire information about their environment. Olfactory signals delivered via urine, faeces, and glandular secretions, serve critical functions in reproductio...

Antiphospholipid antibodies can cause recurrent thrombotic attacks in some patients. Antiphospholipid antibodies are detected in patients with autoimmune disease especially systemic lupus erythematosus, infectious, malig...

BackgroundCatastrophic antiphospholipid syndrome (CAPS) is a rare and life-threatening manifestation of antiphospholipid syndrome (APS), which is frequently later diagnosed with high mortality.Case reportA 54-year-old wo...

Abstract Background Autoimmune conditions are common in women of reproductive age. They are associated with an increased risk of adverse pregnancy outcomes; whether this is causal is unclear. Our aim was to explore the c...

OBJECTIVE: Renal biopsy is a well-established method that is used to diagnose renal parenchymal diseases. In this study, we aimed to determine the frequencies of glomerulonephritis diagnosed histopathologically with rena...

BackgroundSolid organ transplantation is an effective treatment for end-stage organ diseases, including renal, hepatic, cardiac, and pulmonary failure (1). Long-term graft survival depends on sustained immunosuppression;...

Cutaneous lymphatic vessels are essential for maintaining tissue homeostasis and coordinating immune defence, making them vital to skin health. Recent advances in molecular biology and immunology have revealed the associ...

Kidney may be affected by many types of systemic disease and play an important role on the diagnosis and treatment of these systemic illnesses. Many immuncomplex diseases like systemic lupus 'erythematosus (SLE), Henoch ...

Objective To assess the effectiveness of belimumab (BEL) in improving anaemia, thrombocytopenia, lymphopenia and leucopenia in patients with SLE.Methods The BeRLiSS (Belimumab in Real Life Setting Study) 2.0 cohort inclu...

Epidemiologies of nephropathies differ in different geographical and developmental areas. In order to determine the region’s adult nephropathy profile, consecutive renal biopsies performed between January 1997 and Dece...

Percutaneous renal biopsy is an important method to establish a pathological diagnosis, to monitor the disease progression and to assess the response to therapy in children. The aim of this retrospective study was to ana...

OBJETIVO: Avaliar a resposta ovariana após uso de ciclofosfamida (CFM) em pacientes com lúpus eritematoso sistêmico (LES) e correlacionar os achados de tempo de doença e idade no período de utilização de CFM e dos...

BackgroundGATA2 deficiency results from heterozygous pathogenic variants in the GATA2 gene, which encodes a zinc-finger transcription factor essential for hematopoietic stem and progenitor cell development. It is a highl...

Abstract Background Periodontal disease exhibits bidirectional associations with autoimmune diseases; however, comprehensive histological, radiographic, and correlational differences in periodontal tissues between patien...

IntroductionComplement C2 deficiency is a classical pathway defect associated with recurrent infections and autoimmunity. This case demonstrates the need for increased awareness amongst rheumatologists for the indication...

Objective: Renal biopsy plays a crucial role in the diagnosis and treatment of renal diseases. The aim of the present study was to review the reasons leading to biopsy and the pathological diagnoses and to investigate th...

Abstract Objective This study aimed to identify and analyze the interaction structures (ISs) (patterns of reciprocal interaction between the patient-therapist dyad) that characterize the process of a successful long-te...