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Transthyretin (TTR) amyloid cardiomyopathy occurs when stable TTR, normally a 4-protein tetramer, becomes misfolded and aggregates to form amyloid fibrils that accumulate in the heart. Progressive accumulation causes car...

Abstract Trypanosoma cruzi infection in dogs can cause heart failure and sudden death with few treatment options available. A litter of 4 dogs living in a T cruzi endemic area were randomized to prophylaxis and nonprophy...

Abstract Background Distal renal tubular acidosis (dRTA) is an uncommon renal tubular disorder marked by impaired distal nephron acid excretion, resulting in hyperchloremic metabolic acidosis, persistent alkaline urine, ...

Abstract Background Postoperative junctional ectopic tachycardia (JET) is a frequent, hemodynamically consequential arrhythmia after congenital heart surgery. Ivabradine is increasingly used off-label, but its effectiven...

BackgroundEvidence suggests that 41% of ICU patients acquired postextubation dysphagia, substantially increasing the risk of aspiration and malnutrition. Studies on its prevalence and risk factors showed considerable var...

Background: Drug-resistant tuberculosis (DR-TB) is a major public health challenge in Sub-Saharan Africa (SSA), worsened by high HIV prevalence and limited healthcare infrastructure. Bedaquiline, a cornerstone DR-TB trea...

Abstract Background Prolonged corrected QTcs are a frequent and potentially life-threatening finding In ICU patients, the presence of prolonged QTc is a prevalent and potentially life-threatening condition, as it increas...

OBJETIVO: analisar o diagnóstico, evolução e conduta terapêutica em cinco casos de tumores cardíacos primários diagnosticados no período pré-natal. MÉTODOS: no período de Janeiro 1997 a Dezembro 2008, 7.989 ges...

Rhabdomyolysis is a condition of muscle tissue release including after necrosis of muscle due to a direct or indirect muscle injury. Rhabdomyolysis is mostly asymptomatic but hypovolemic shock, cardiac arrhythmias or acu...

Goal: To enable comfortable and non-invasive heart rhythm monitoring, this work aims to reconstruct electrocardiogram (ECG) signals from photoplethysmogram (PPG) signals, eliminating the need for multiple electrode attac...

Current management does not fully prevent arrhythmias in long QT syndrome (LQTS), underscoring a need for novel therapies. Here, we investigated potential beneficial effects of serum/glucocorticoid-regulated-kinase-1 (SG...

Circadian rhythms are generated by endogenous pacemakers that rely on transcriptional-translational feedback mechanisms conserved among species. In Drosophila, the stability of a key pacemaker protein PERIOD (PER) is tig...

ABSTRACT Background and Aims Atrial fibrillation (AF) is a common cardiac arrhythmia with a rising global incidence. Advances in ablation techniques have led to same‐day discharge (SDD) protocols, reducing hospital res...

L-carnitine (L-C) deficiency seen in chronic hemodialysis (HD) patients may contribute to heart failure and arrhythmias, through damaging the myocardial energy metabolism. In this study, the effect of L-C treatment on le...

OBJECTIVE: In hemodialysis patients; there is a continuing tendency to metabolic acidosis. In studies, the relationship between serum bicarbonate concentration and dialysis mortality has been determined. In our study, th...

OBJECTIVE: Sudden cardiac death and risk of arrhythmia are higher in patients with ESRD. Tp-e/ QT, and Tp-e/QTc are novel and more reliable indexes of ventricular arrhythmogenesis and sudden cardiac death than QTc. The a...