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Abstract Background In photosynthetic eukaryotes of the green lineage, the expression of the chloroplast genome is mainly regulated post-transcriptionally, by RNA-binding proteins encoded in the nuclear genome termed org...

Abstract Background Heavy metal pollution, particularly cadmium (Cd), poses a significant threat to the environment, human health and plant growth. Taurine is an amino acid with antioxidant properties. The effect of taur...

Abstract Objective Thyroid-stimulating hormone beta subunit (TSHB) gene, a member of the glycoprotein hormone beta subunit family, has been detected in ovarian tissues and granulosa cells (GCs) of several species, sugges...

Abstract Medicinal leeches are rich in various antithrombotic components, holding significant pharmaceutical value. To investigate the differences in potential antithrombotic capacity among species, this study utilized t...

Abstract Vertebrate chemoreceptor genes play a central role in detecting environmental chemical compounds through the olfactory organs and taste buds, enabling the perception of odors and tastants that are critical for s...

Abstract Background Congenital anomalies of the kidney and urinary tract (CAKUT) comprise a heterogeneous group of developmental disorders with diverse genetic etiologies. However, it remains unclear whether these geneti...

Abstract Background Recent studies have shown that antimicrobial resistance has become a great threat. This study focuses on and investigates the effect of some natural compounds on the expression of efflux pump genes th...

Abstract Background Zanthoxylum armatum is a vital economic crop in China, but its cultivation is challenged by abiotic stresses like drought and cold. Mitogen-activated protein kinase kinases (MAPKKs) are central signal...

Abstract The MYB transcription factor family is one of the largest and most functionally diverse groups of transcription factors in angiosperms. Members of this family participate in a wide array of biological processes,...

Abstract Objective This study aimed to investigate the effect of miRNAs differentially expressed in serum exosomes on endothelial cells after myocardial infarction. Design & methods Specific pathogen-free male Sprague–...

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) stands as the most widespread chronic liver disorder globally. Histone β-hydroxybutyrylation (Kbhb)—a novel post-translational modif...

Abstract Background Epigenetic mechanisms including DNA methylation are assumed to play crucial roles in the maintenance of genome integrity, regulation of gene expression and development, and their increasing exploitati...

Abstract Background Endometriosis is a highly prevalent, hormone-driven chronic disease characterized by the growth of endometrial tissue outside the uterine cavity. Despite its impact, the mechanisms underlying the dise...

Abstract Objective This study aimed to systematically identify and validate KIF15 as a potential diagnostic and prognostic biomarker in colon cancer (CC) using integrated bioinformatics analyses. We further explored its ...

Abstract Background Endoplasmic reticulum stress (ERS) is linked to the progression of atherosclerosis (AS). The function of ERS-related genes (ERSRGs) in AS remains ambiguous, hence, this study sought to examined their ...

Abstract Background Single-cell RNA sequencing (scRNA-seq) is considered a revolution in gene expression studies and offers significant benefits across various fields of biomedical or clinical applications. However, a hi...

Abstract Background Aging alters the systemic steroid environment, including reductions in circulating androgens. In peripheral tissues, androgen exposure is regulated mainly by local steroid metabolism, which can activa...