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Abstract Background Heart failure with preserved ejection fraction (HFpEF) disproportionately affects elderly women and is closely associated with central obesity and metabolic dysfunction. Although sodium-glucose co-tra...

Abstract Water is vital to life, so preserving it from pollution is an important issue. Chromium, in its various oxidation states, poses a significant threat to water contamination. This study analyzes the sulfonation pr...

Abstract Background Adipose tissue is increasingly recognized as an important component of the tumor microenvironment of colorectal cancer (CRC) and actively contributes to the progression of the disease. Adipose stem ce...

Abstract Background Existing research suggested that the intratumoral microbiome participates in the progression and metastasis of lung cancer. However, its role in distinguishing benign from early-stage malignant pulmon...

Abstract Background Variants in OTUD5 are associated with neurodevelopmental disorders (NDDs), yet the underlying molecular mechanisms remain unclear. This study aimed to investigate the pathogenicity of a novel OTUD5 va...

Abstract Automobile cabin air filter-deposited particulate matter represents an underappreciated exposure source, yet the differential toxicity between filter sides and underlying mechanisms remain unclear. Here, we syst...

Abstract Background Lavandula stoechas L., commonly known as lavender, has been traditionally used in various therapeutic applications, including as a smoking cessation aid. The aim of this study was to investigate the a...

Abstract Background Chronic liver disease (CLD) and heart disease (HD) are major contributors to global morbidity and mortality. Although increasing evidence supports close interactions between the liver and heart, popul...

Abstract Background Rifampicin-resistant tuberculosis (RR-TB) remains a major public health concern, particularly in African populations where undernutrition is common. Many participants with RR-TB initiate treatment wit...

Abstract Background Ambient air pollution has been linked to atrial fibrillation (AF), yet the underlying metabolic mechanisms remain poorly understood. Methods We analyzed 227,324 UK Biobank participants without baselin...

Abstract Background Dengue fever is hyperendemic in the Lao People’s Democratic Republic (PDR), where transmission is driven by Aedes mosquitoes and influenced by large-scale climatic phenomena, including the El Niño-...

Abstract Background Epithelial ovarian cancer (EOC) is a highly heterogeneous malignancy with significant morbidity and mortality, and cisplatin (DDP) resistance remains a major obstacle in its treatment. Previous studie...

Abstract Objective Retinal neovascularization is a leading cause of irreversible blindness worldwide. Chinese herbal medicines have unique therapeutic properties, such as antioxidant, anti-inflammatory, and neuroprotecti...

Abstract Background Leishmaniasis is a vector-borne parasitic disease caused by Leishmania protozoa. The disease manifests in several clinical presentations including cutaneous, mucocutaneous, and visceral leishmaniasis....

Abstract Rift Valley fever (RVF) is a mosquito-borne zoonosis of major concern for human and animal health, yet no licensed human vaccine exists. Here, we engineered a self-assembling nanoparticle vaccine candidate by ge...

Abstract Background Olfactory detection of host odors is fundamental to mosquito host-seeking behavior. Although the olfactory pathways of model species such as Anopheles gambiae have been well characterized, the molecul...

Abstract Background Coffee is among the most widely consumed beverages globally, yet evidence specifically examining its association with heart failure (HF) risk remains limited. The only dedicated meta-analysis on this ...

Abstract Introduction College students face increasing physical and psychological challenges, and the multidimensional association between physical activity and well-being warrants clarification. This study tested an int...

Abstract Background Visceral obesity contributes to hypertension through pathways of insulin resistance and inflammation. The joint association of C-reactive protein-triglyceride-glucose index (CTI), which integrates the...

Abstract Background Excessive mechanical stress is a major cause of intervertebral disc degeneration (IVDD). Macrophages can sense physical signals, but their role in responding to mechanical stress within the disc to ma...

Abstract Background Drug-induced liver injury (DILI) remains a significant barrier to the safe and efficient use of antimalarial medicines. Many promising compounds fail in late-stage development or post-marketing owing ...

Abstract Background Gut microbiota dysbiosis is a key pathological feature closely linked to metabolic disorders and neuroinflammation. It is typically characterized by reduced levels of beneficial microbial metabolites,...

Abstract Background Acute respiratory distress syndrome (ARDS) is a severe clinical syndrome with limited therapeutic options. Acute lung injury (ALI) is widely used as an experimental animal model that recapitulates the...

Abstract Background Diabetes is associated with a high incidence of diabetic foot and peripheral artery disease and with markedly increased lifetime amputation risk. Here we investigated predictors of reamputation risk a...