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Objective: Hematopoietic stem cell transplantation (HSCT) is an effective treatment for acute myeloid leukemia (AML) patients, leveraging cytotoxic conditioning regimens and graft-versus-leukemia effects. Reduced-intensi...

Background: Spinal cord injury (SCI) has emerged as a major challenge to global public health due to its low recovery rate and high disability rate, making the development of novel therapeutic approaches imperative. Mese...

Introduction and aims: Human dental pulp stem cells (hDPSCs) play pivotal roles in the regeneration of pulp-dentin complex, yet their odontogenic differentiation is critically modulated by the inflammatory microenvironme...

Anterior-posterior (AP) spatial regionalization is crucial for central nervous system development. Previous studies suggest that morphogen gradients can induce AP patterning in animal and organoid models. While self-orga...

Lissencephaly type 10 (LIS10, OMIM#618873) is a rare neurodevelopmental disorder characterized by posterior-predominant pachygyria/agyria or subcortical band heterotopia on brain imaging. Clinically, affected individuals...

Drug discovery research faces significant challenges, with around 90 % of candidate drugs failing in clinical trials. Traditional animal models do not always accurately reflect human physiology and pathology, leading to ...

Subretinal delivery of retinal pigment epithelium (RPE) cells is an important treatment for retinal degeneration patients, and the cell suspension method is the most common approach. Injectable hydrogel-mediated cell eng...

Introduction and aims: Increasing evidence suggests that marginal zone B and B1 cell-specific protein (MZB1) plays crucial roles in inflammatory responses, endoplasmic reticulum (ER) stress, and cell survival, but its fu...