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Regulatory science governing monoclonal antibody development has undergone a profound transformation over the past decade, shifting from empiricism-driven paradigms toward evidence-efficient, mechanism-based frameworks g...

ObjectiveTo summarize the best evidence for non-surgical intervention in periodontitis among patients with type 2 diabetes mellitus, and to provide a basis for medical and nursing staff to carry out periodontitis managem...

Materias / palabras clave: clinical decision making; evidence based practice; evidence based treatment; intervention planning; treatment planning

ObjectiveChronic pain, a major global public health burden, is primarily driven by altered central pain processing, which conventional treatments rarely target directly. This systematic review and meta-analysis synthesiz...

IntroductionUnderstanding the progression of dental caries in children, characterized by transitions between distinct health states, may benefit the development of prevention and disease modeling frameworks. This systema...

Shenfu Injection (SFI) is a standardized botanical drug derived from two Chinese medicinal herbs Panax ginseng C.A.Mey. and Aconitum carmichaelii Debeaux. SFI is historically used for “restoring yang and reversing coll...

BackgroundMetabolic syndrome (MetS) affects approximately 1.54 billion adults worldwide and is characterized by central obesity, insulin resistance, hypertension, and dyslipidemia. Chronic low-grade inflammation is cen...

Background/objectivesAcupuncture is recommended for the treatment of cancer-related fatigue (CRF), but the strength of evidence remains limited. This study aims to comprehensively update the evaluation of the effectivene...

ObjectivesTo conduct a scoping review mapping the extent, nature, and consistency of available evidence regarding the effects of sodium–glucose cotransporter-2 (SGLT2) inhibitors on kidney function, proteinuria, kidney...

BackgroundThe intestinal barrier is a critical interface between the host and the external environment, and growing evidence indicates that bidirectional crosstalk between the gut microbiota and the intestinal barrier is...

BackgroundAn interdental brush (IDB) is an adjunctive oral-hygiene tool designed to clean interproximal spaces and remove dental plaque. This study systematically evaluated its effectiveness for improving oral hygiene an...

ObjectiveThe present Bayesian network meta-analysis (NMA) aims to evaluate and compare the efficacy of aerobic training (AT), resistance training (RT), high-intensity interval training (HIIT), and combined training (CT) ...

PurposeNutrition care is essential for improving oncology treatment outcomes, however evidence on current practices and adherence to the Nutrition Care Process framework in Indonesia is scarce. This study explored oncolo...

Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. Over the past three decades, percutaneous coronary intervention (PCI) has evolved from a anatomical revascularization technique ...

BackgroundSexual minority women (SMW), including lesbian, bisexual, and other non-heterosexual women, experience higher rates of substance use (SU) and substance use disorders (SUDs) than heterosexual women, yet remain r...

PurposeThe rehabilitation of neurodevelopmental disabilities is a complex process aimed at enhancing children’s functional abilities, minimizing the impact of disabilities on family dynamics, and promoting autonomy in ...