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IntroductionPediatric-onset multiple sclerosis (POMS) poses unique therapeutic challenges due to high inflammatory activity, early cognitive and psychosocial impact, and difficulties with long-term treatment adherence. T...

IntroductionThe aim of the study is to investigate the association between fatigue, cognitive impairment, and overall QoL in individuals with Multiple Sclerosis (MS).MethodsFifty-one patients with MS with a confirmed dia...

BackgroundQuality of life (QoL) in multiple sclerosis (MS) is multifactorial, reflecting the combined effects of physical disability, cognitive impairment, and depressive symptoms. While physical disability is a key dete...

IntroductionMultiple sclerosis (MS) shows marked female predominance, particularly among women of childbearing age (WCBA, 15–49 years), yet their specific disease burden remains under characterized. Using Global Burden...

BackgroundMS and NMOSD are chronic demyelinating diseases related to demyelinating attacks on the central nervous system which limit quality of life and predisposes patients to developing anxiety and depression which, in...

The application of Chimeric Antigen Receptor T-cell (CAR-T), CAR-engineered regulatory T cell (CAR-Treg) and hematopoietic stem cell (HSC) therapies has grown in recent years, driven by an increasing demand for robust, a...

Background and ObjectiveDifferentiating neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) is clinically difficult, especially when patients are seronegative for anti–aquaporin-4 immunoglobulin...

Ferroptosis is a form of regulated cell death driven by iron-dependent lipid peroxidation, which plays a pivotal role in regulating the inflammatory-immune microenvironment of central nervous system (CNS) diseases. Mount...