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Abstract Cattle are the mammalian species with most global biomass, encompass the two subspecies Bos taurus and Bos indicus, which are phenotypically distinguishable and have distinct genetic backgrounds. We used fresh p...

Abstract The significant economic burden of colorectal cancer (CRC) necessitates the development of innovative therapeutic approaches. Interest in the gut microbiota’s role in CRC has increased. Capecitabine, as a chem...

Abstract Bovine respiratory disease (BRD) remains the leading cause of morbidity and economic loss in North American cattle production. Cattle at high risk of BRD are often managed through antimicrobial metaphylaxis, alt...

Abstract Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy characterized by profound molecular heterogeneity and poor prognosis. Programmed cell death (PCD) regulates tumor progression and shapes the tum...

Abstract Vibrio cholerae is a human diarrheal pathogen and an estuarine organism that associates with both terrestrial and aquatic arthropods. Using the model terrestrial arthropod Drosophila melanogaster, we previously ...

Abstract Immunotherapy has transformed melanoma treatment, yet only a subset of patients benefit and clinically effective biomarkers remain limited. Here, we report a comprehensive analysis evaluating CD27 as a predictiv...

Abstract TP53 is frequently mutated in bladder cancer and is associated with aggressive disease, yet actionable strategies that also improve responses to immune checkpoint blockade remain limited. Here we show that APR-2...

Abstract Prostate cancer (PCa) is a leading malignancy in men, particularly challenging in its advanced stages due to treatment resistance and immune evasion. MicroRNA-1290 (miR-1290) was identified to be implicated in t...