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Introduction. Cutaneous melanoma is a malignant tumour derivedfrom melanocytes that occurs primarily in the skin. It is a result of prolongedexposure to mutagenic factors and an abnormal DNA repairsystem. The pathogenesi...

Introduction. Autoimmune polyglandular syndrome type 1 (APS-1) is a type of polyendocrinopathy, inherited in an autosomal recessive manner. Beside the classic triad of symptoms (candidiasis of the skin and mucous membr...

α1-Antitrypsin (AAT) is a serine protease inhibitor responsible forregulating proteinases' activity in the blood. α1-Antitrypsin deficiencyis a result of SERPINA 1 gene mutation and it is one of the most commongenetic ...

Materias / palabras clave: isotretinoin; insulin; glucose; insulin growth factor-1; insulin-like growth factor-3 binding protein

Occupational diseases are characterised by a diverse aetiology. The causative agents may be chemical, physical or biological. In the past 14 years there has been a decrease in the number of reported occupational dermatos...

Introduction . Syphilis is a sexually transmitted disease that can be asymptomatic or associated with various symptoms including systemic manifestations. A total of 1,253 cases of syphilis were registered in Poland in 20...

This guideline is the result of a systematic literature review using the ‘Grading of Recommendations Assessment, Development and Evaluation’ (GRADE) methodology and a structured consensus conference held on 28 and 29...

Materias / palabras clave: psoriasis; children; treatment; recommendations

Rosacea is a chronic, relapsing, inflammatory, but not infectious, skin disease. The prevalence of rosacea is relatively high in the adult population of Northern Europe. Its characteristic symptoms include recurrent flus...

Introduction. Skin tags are known to be associated with several systemic diseases such as diabetes mellitus, obesity, dyslipidemia and cardiovascular diseases. Only a few Indian studies have investigated patients with ...

Morphea en coup de sabre is a type of linear localized scleroderma, characterized by a sclerotic skin band in the forehaead and frontoparietal scalp area. It can cause cicatricial alopecia, when affecting the scalp. The ...

We report the case of a 36-year-old male patient with alcohol dependence syndrome who was admitted to the Dermatology Unit with erythroderma of unknown aetiology persisting for approximately 2 years. A considerable degre...

Dermatomyositis is an autoimmune disease characterized by skin lesions and/or symptoms of myositis. In addition to the so-called classic dermatomyositis the following forms of dermatomyositis are distinguished based on t...

Wprowadzenie: Dipeptydylowa aminopeptydaza IV, znana równieżjako antygen CD26, odgrywa istotną rolę w patogenezie pierwotnychskórnych chłoniaków T-komórkowych (ang. cutaneous T-cell lymphoma– CTCL). Obecnie uwa...

Introduction. Necrobiosis lipoidica (NL) is a granulomatous skin disease of still only partially known pathogenesis. Microangiopathy is considered as one of the most important processes in NL, and vascular endothelial ...

The large surface area of the skin, high metabolism and location at the border of two environments (external and internal) cause continuous production of free radicals within the skin. There are two mechanisms of skin ph...

Griscelli syndrome is a rare autosomal recessive disorder characterized by hypopigmentation of skin and hair. Griscelli syndrome type 2, one of the three subtypes of Griscelli syndrome, is characterized by recurrent infe...