NODOVOX | Discovery

Small-angle X-ray scattering to quantify the incorporation and analyze the disposition of magnetic nanoparticles inside cells

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Small-angle X-ray scattering to quantify the incorporation and analyze the disposition of magnetic nanoparticles inside cells

Coral, Diego Fernando et al · Academic Press Inc Elsevier Science · 2022 · ISSN 0021-9797

Access to detailed information on cells loaded with nanoparticles with nanoscale precision is of a long-standing interest in many areas of nanomedicine. In this context, designing a single experiment able to provide stat...

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CircSPARC mediates an immunosuppressive tumor microenvironment by regulating the miR-199a-5p/LASP1 axis in non-small cell lung cancer

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CircSPARC mediates an immunosuppressive tumor microenvironment by regulating the miR-199a-5p/LASP1 axis in non-small cell lung cancer

Chengsheng zhang et al · BMC · 2026 · ISSN 1471-2466

Abstract Non-small cell lung cancer (NSCLC) is a major cause of cancer-related mortality globally, linked to an immunosuppressive microenvironment. Circular RNA circSPARC is crucial in cancer, but its function in NSCLC r...

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Cytotoxicity and anticoccidial activities of Artemisia sieberi leaf extract: an in vitro study

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Cytotoxicity and anticoccidial activities of Artemisia sieberi leaf extract: an in vitro study

S.N. Maodaa et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2024 · ISSN 1678-4162

ABSTRACT For centuries, medicinal plants with abundant supplies of phytochemicals that are physiologically active have been used in traditional medicine. Numerous of these contain anti-inflammatory and antioxidant qualit...

LCC LCC:Animal cultureIdioma eng

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Dual-targeting phytochemicals Ergosterol and Quercetagetin implicate steroid metabolism–associated pathways in lung and liver cancer models

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Dual-targeting phytochemicals Ergosterol and Quercetagetin implicate steroid metabolism–associated pathways in lung and liver cancer models

Yujiao Chen et al · Frontiers Media S.A · 2026 · ISSN 1663-9812

IntroductionHormone-associated cancers use steroid metabolism to grow and avoid the immune system, while traditional treatments have to deal with drug resistance and systemic toxicity.MethodsThis study is mainly divided ...

LCC LCC:Therapeutics. PharmacologyIdioma eng

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Fc-mediated antibody functions are associated with disease severity in COVID-19

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Fc-mediated antibody functions are associated with disease severity in COVID-19

Sungim Choi et al · Frontiers Media S.A · 2026 · ISSN 1664-3224

IntroductionFc-mediated antibody effector functions play key roles in both antiviral immunity and immunopathology in COVID-19. While antibody-dependent cellular phagocytosis (ADCP) and antibody-dependent cellular cytotox...

LCC LCC:Immunologic diseases. AllergyIdioma eng

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PDPK1 activates BIRC3 via NFKB1 to promote radiotherapy resistance in lung adenocarcinoma

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PDPK1 activates BIRC3 via NFKB1 to promote radiotherapy resistance in lung adenocarcinoma

Huaping Shao et al · BMC · 2026 · ISSN 1475-2867

Abstract Radiotherapy resistance (RT resistance) remains a major obstacle in lung adenocarcinoma (LUAD) treatment, with dysregulated apoptosis being a key contributor. This study aim to investigate the role of PDPK1 in R...

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Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation

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Rnd3 regulates lung cancer cell invasion and migration independently of ROCK1 signaling via alpha 5 integrin modulation

Noemi Garcia Garcia et al · Life Science Alliance LLC · 2026 · ISSN 2575-1077

Here, we identify a novel signaling pathway in which Rnd3 regulates the metastatic potential of lung cancer cells. Understanding this pathway could be leveraged to target metastatic disease. Rnd3 regulates cellular proce...

LCC LCC:Medicine; LCC:Biology (General)Idioma eng

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Single-cell mitophagy signature-based artificial intelligence model enhances prediction of prognosis and immunotherapy response in non-small-cell lung cancer

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Single-cell mitophagy signature-based artificial intelligence model enhances prediction of prognosis and immunotherapy response in non-small-cell lung cancer

Ming-Hao Wang et al · BMC · 2026 · ISSN 1465-993X

Abstract Background Non-small-cell lung cancer (NSCLC) exhibits pronounced molecular heterogeneity, and current predictive models rarely incorporate mitochondrial quality-control programs such as mitophagy. We hypothesiz...

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Ternary copper(II) complex of 5-hydroxytryptophan and 1,10-phenanthroline with several pharmacological properties and an adequate safety profile

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Ternary copper(II) complex of 5-hydroxytryptophan and 1,10-phenanthroline with several pharmacological properties and an adequate safety profile

Naso, Luciana Gissella et al · Elsevier Science Inc · 2019 · ISSN 0162-0134

We report the synthesis and biological evaluation of a ternary copper complex, [Cu(5HTP)(phen)(H2O)](NO3).2H2O, with the antioxidant agent 5-hydroxytryptophan (5-HTP) and phenanthroline (phen, added to improve its lipoph...

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USP4 promotes non-small cell lung cancer tumorigenesis by antagonizing CNOT4-mediated degradation of PAF1

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USP4 promotes non-small cell lung cancer tumorigenesis by antagonizing CNOT4-mediated degradation of PAF1

Shaomu Chen et al · BMC · 2026 · ISSN 1465-993X

Abstract Background Non-small cell lung cancer (NSCLC) is a leading cause of cancer mortality. This study examines whether the deubiquitinase USP4 promotes NSCLC progression by stabilizing PAF1 and opposing the E3 ligase...

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c-Jun Proto-Oncoprotein Plays a Protective Role in Lung Epithelial Cells Exposed to Staphylococcal α-toxin

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c-Jun Proto-Oncoprotein Plays a Protective Role in Lung Epithelial Cells Exposed to Staphylococcal α-toxin

Moyano, Alejandro Jose et al · Frontiers Media SA · 2018 · ISSN 2235-2988

c-Jun is a member of the early mammalian transcriptional regulators belonging to the AP-1 family, which participates in a wide range of cellular processes such as proliferation, apoptosis, tumorigenesis, and differentiat...

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