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Abstract One of the main obstacles to starting successful coffee plantations is the asynchronous and slow germination of Coffea arabica L seeds. Seed priming increases the percentage of germination. Several studies have ...

Abstract Eastern Himalayan Region (EHR), where rice is an important staple crop, developing drought stress tolerant varieties is crucial for improving yield and stability in variable climates. Genotype-by-environment (GE...

1. El stock de carbono orgánico del suelo (COS) es un indicador de la calidad y salud del suelo. Su dinámica tiene un papel significativo en el balance global de las emisiones de gases con efecto invernadero (GEI). Los...

Abstract Graph Neural Networks (GNNs) are powerful tools for predicting chemical shifts in Nuclear Magnetic Resonance (NMR) spectroscopy. In this paper, we improve the state-of-the-art mean absolute error (MAE) on the Il...

Abstract Bacteria adjust their metabolism to the cellular energy state. AMP-forming acetyl-CoA-synthetase AcsA generates acetyl-CoA from acetate, ATP and CoA. In Bacilli, including Bacillus subtilis and Geobacillus stear...

The European Union (EU) is currently overhauling its pharmaceutical regulations, seeking to mature a single market for medicines as part of a ‘European Health Union’. We reflect on the interactions between regulation...

BackgroundNFKB1 encodes for the p105/p50 nuclear factor-kappa-B (NF-kB1) transcription factors. Heterozygous mutations in NFKB1 may lead to NF-kB1 insufficiency, which may result in a multiorgan disease. Here, we aimed t...

BackgroundAtaxia-telangiectasia (A-T) is a rare autosomal recessive disorder caused by pathogenic variants in the ATM gene and characterized by genomic instability, immunodeficiency, and a markedly increased risk of canc...

Background & Aims: Atezolizumab/bevacizumab (A/B) and durvalumab ± tremelimumab (DT/D) are preferred first-line regimens for the treatment of hepatocellular carcinoma (HCC). Although both therapies share an anti-PD-...

Abstract Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA expression in livi...

Os periódicos científicos são fundamentais para a comunicação e a preservação da memória acadêmica. Este estudo analisa a trajetória dos periódicos da Universidade Federal Fluminense, com foco em seu portal de...

Abstract Top-down trophic interactions are major drivers of microbiome dynamics, yet their outcomes are difficult to predict and their consequences for pathogen control remain unclear. We combine synthetic bacterial comm...

Abstract Ewing sarcoma (EWS), a rare pediatric bone tumor, poses unique therapeutic challenges due to its distinct microenvironment and limited molecular understanding. To gain a comprehensive molecular and functional vi...

BackgroundNFKB1 encodes the p105/p50 nuclear factor-kappa-B (NF-κB1) transcription factor. Heterozygous mutations in NFKB1 are associated with NFKB1-related disease, including granulomatous-lymphocytic interstitial lung...

IntroductionThe World Health Organization classification of tumors of hematopoietic and lymphoid tissues recognizes acute erythroid leukemia as a distinct entity under myeloid neoplasms. Erythroblastic sarcoma, also know...

Abstract Background Neuropsychiatric symptoms (NPS) are highly prevalent in nursing home residents. The main aims of this study were to examine whether music-based care (MBC) had sustained effects on NPS in nursing home ...