Buscar recursos académicos

Endometriosis is a chronic, estrogent-dependent, inflammatory disease affecting a plethora of women of reproductive age and is a major cause of pelvis pain and subfertility. Current treatments – surgery and hormonal su...

Metformin is the most widely used oral antidiabetic drug in the world. It is the first-line drug in type 2 diabetes, where its inhibiting effect on hepatic glucose production, increasing muscle and adipose tissue insulin...

Abstract Objective: The aim of this study is to assess the use of metformin with or without insulin for the treatment of Gestational Diabetes Mellitus compared to insulin alone. Data sources: This article consists of a...

A 65-year-old man was admitted to the emergency department with the complaints of general discomfort, nausea, vomiting, abdominal pain, dysuria and shortness of breath. Type II diabetes mellitus, essential hypertension, ...

Spinocerebellar ataxia type 8, a debilitating neurological disease with no effective treatment, is caused by a CAG•CTG expansion mutation. In SCA8 mice, metformin decreases repeat-associated non-AUG proteins and neuroi...

Aging is an irreversible and natural phenomenon. At the biological level, aging is caused by various molecular and cellular damages over time. Evidence of Anti-aging were observed in Yeast, Worms and Mice with metformin....

Abstract PBRM1-mutant ccRCC is a subtype of ccRCC with limited treatment options. Currently, there were no effective drugs specifically targeting this mutation. Here, we discovered that PBRM1-mutant ccRCC patients with c...

Abstract Background Metformin has emerged as a potential bioactive agent in regenerative medicine; however, its optimal concentration for enhancing dental pulp stem cell (DPSC) function remains unclear. This study evalua...

Abstract Objective To assess the effectiveness of metformin in the incidence of gestational diabetes mellitus (GDM) in obese pregnant women attending a public maternity hospital in Joinville, Santa Catarina, Brazil. M...

Aims Deleterious effects of metabolic syndrome (MS) on bone are still controversial. In this study we evaluated the effects of a fructose-induced MS, and/or an oral treatment with metformin on the osteogenic potential of...

الملخص: Image 1 Abstract: Objective: To improve clinical and radiographic results in patients with periodontitis, this systematic review assessed the efficacy of metformin (MF) as an adjuvant to surgical and nonsu...

This study explores the synergistic effects of Resveratrol and Metformin on improving insulin sensitivity and ovulatory function in women with Polycystic Ovary Syndrome (PCOS). As a complex condition, PCOS is characteriz...

Metformin is a biguanide used in the treatment of type 2 diabetic patients with normal renal function. Lactic acidosis is the most serious side effect of metformin. Renal failure is the most common cause of reduced lacta...

Heavy proteinuria and nephrotic syndrome may occur in association with a wide variety of primary and systemic diseases and also with drugs. Major drugs that can induce nephrotic syndrome and glomerular damage are gold, p...

Objective Gestational diabetes mellitus (GDM) refers to glucose intolerance, insulin sensitivity, and beta islet cell dysfunction during pregnancy. GDM pathogenesis is associated with hypertension, impaired placental and...

The present study investigated the role of the N, N{ 0 }-dimethylbiguanide metformin (50 mg/100 g body weight in 0.05 ml water, given orally with a canulla) in the prevention of endocrine and immune disorders provoked by...

Introduction. According to the literature, mortality among patients with schizophrenia is 1.5 -2 times higher than in the healthy population. One explanation for this is the complication of neuroleptic therapy, which, ac...

Materias / palabras clave: Diabetic neuropathy; Medication adherence; Metformin; KSA; Type 2 diabetes; Vitamin B12 Deficiency

NK cells-based cancer therapy combined with chemotherapeutic drugs for the treatment of tumors can enhance the immunosensitivity of NK cells, increase the expression of NK cell receptors, and eventually boost the killing...

Periodontitis, a chronic inflammatory disease induced by pathogenic microorganisms. Effective management requires the elimination of plaque biofilms, the suppression of oxidative stress, and the regeneration of periodont...

Introduction: Diabetic Neuropathy (DN) is a common and debilitating complication of Diabetes Mellitus (DM), involving the sensory, motor, and autonomic nervous systems, with limited disease-modifying treatment options. E...

Abstract Background Autologous fat transplantation (AFT) is widely used in aesthetic and reconstructive surgery, but its long-term outcomes remain unpredictable because of complications such as oil cyst formation, the un...

Abstract Background Polycystic ovary syndrome (PCOS) is characterised by insulin resistance and hyperandrogenism; whether novel antidiabetic drugs differentially improve these metabolic and reproductive disturbances rema...

Abstract Background Diabetes is a major global public health burden. Effective diabetes management is highly dependent on the availability of affordable and quality-assured essential medicines (EMs) which is a challenge ...