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ABSTRACT Background and Aims Nicotine dependence is a growing concern, particularly among young adults. While e‐cigarettes are marketed as smoking cessation tools, evidence suggests they may contribute to increased dep...

Abstract Background Cardiac fibrosis is a pivotal pathological process driving adverse cardiac remodeling and a defining feature of end-stage heart disease. Nicotine, a principal constituent of tobacco products, is now r...

Descriptive Consumer-Reported Outcome Measures (CROM) are self-reported survey outcome measures intended to measure observable characteristics and behaviors in research on tobacco- and nicotine-containing products (TNPs)...

Parkinson’s disease (PD) is characterized by profound metabolic disturbances in the brain, yet how these alterations vary across brain regions and respond to neuroprotective intervention remains poorly understood. Here...

AbstractPsychostimulants regulate behavioral responses in zebrafish via epigenetic mechanisms. We have previously shown that DNAmethylation and histone deacetylase (HDAC) inhibition abolish nicotine-induced conditioned p...

Given the well-documented pharmacological differences between nicotine and nornicotine enantiomers, understanding their distribution is essential. This knowledge also helps authenticate the enantiomers’ source (natural...

100 million adults and 15 million adolescents currently use e-cigarettes, a type of Electronic Nicotine Delivery System (ENDS) or Electronic Non-Nicotine Delivery System (ENNDS). While they were introduced as smoking ces...

A real-time electrochemical sensing strategy for nicotine monitoring in smoke streams was developed using additively manufactured three-dimensional (3D) based on conductive polymer composites. Disc-type microelectrodes (...

BackgroundWith the highest cancer incidence and mortality rates in the country, rural Appalachia has experienced a decades-long health decline, due in part to high smoking rates. Cigarette smoking prevalence exceeds 30% ...

Tobacco harm reduction (THR) using represents a pragmatic and realistic strategy, to which electronic nicotine delivery systems (ENDS) misperceptions act as a barrier. This paper explores ENDS misperceptions, especially ...

Abstract Objective: The aim of this study was to determine which individual characteristics of smokers are associated with their adherence to a support group for smoking cessation. Methods: Smokers from Porto Alegre, B...

Electronic cigarette (e-cigarette) use has risen rapidly over the past decade, particularly among adolescents and young adults, driven by perceptions of reduced harm compared with combustible cigarettes. Despite the abse...

Abstract Background As dementia cases continue to rise, effective prevention strategies are urgently needed. However, objective biomarkers that directly reflect lifestyle factors remain limited. Life’s Essential 8 (LE8...

Aim: Considering the increasing trend of smoking rates among women, it is thought that there is a need for studies examining the relationship between menstrual irregularities and smoking in women of reproductive age. Thi...

BackgroundVaping among adolescents has decreased but remains common among young adults, with ongoing concerns about nicotine health risks. Public health campaigns have increased vaping prevention messages, but evidence o...

Abstract Background Digital health interventions offer a promising opportunity to innovate traditional cessation services. Multi-component digital approaches show potential for greater effectiveness than traditional meth...

ObjectivesThis systematic review evaluated the scientific evidence on the effects of flavors in electronic cigarettes in animal models and their impact on human health, aiming to understand the potential risks associated...

We describe the functional properties of a nicotinic alpha9/serotonin subtype 3A (5HT3A) chimeric receptor expressed in Xenopus laevis oocytes. The chimera preserved ligand-binding properties of alpha9 and channel proper...

Abstract The consumption of tobacco, alcohol, and unhealthy foods is considered the three key factors contributing to preventable morbidity and early mortality worldwide. Inhibitory Control Training (ICT) is suggested as...

Abstract Introduction Tobacco smoking remains a significant global health issue, contributing to preventable morbidity and mortality. Smoking cessation is often hindered by cravings and emotional distress. Cognitive beha...

Abstract Objectives Individuals with schizophrenia spectrum disorders face challenges in maintaining healthy lifestyle habits and have a significantly reduced life expectancy, partly due to increased risks of somatic ill...

IntroductionCurrent regulatory neurotoxicity guidelines do not include behavioral endpoints that capture stress-related responses. Zebrafish larvae prior to independent feeding offer a promising vertebrate model for deve...

The absence of α2* nicotinic acetylcholine receptors (nAChRs) in oriens lacunosum moleculare (OLM) GABAergic interneurons ablate the facilitation of nicotine-induced hippocampal CA1 long-term potentiation and impair mem...

Studying the organoleptic properties of heated tobaccos in relation to natural flavors is essential for understanding how lower-temperature processing influences the release of intrinsic tobacco flavor compounds. Unlike ...