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There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitiv...

Abstract Background As the incidence of ATR is increasing the risk of ruptures being missed escalates and more injuries are suspected to become chronic. This study aimed to assess the incidence and causes of delayed diag...

Abstract Background Nipple discharge is one of the most common breast complaints, reported by 80% of women outside the breastfeeding period. It may result from physiological or pathological causes, including intraductal ...

Abstract Transcriptomics enables comprehensive, multiplexed characterization of cellular states, yet prevailing methods typically require cell fixation or lysis, precluding longitudinal analysis of RNA expression in livi...

ABSTRACT Bacteria can change morphology in response to stressors and changes in their environment, including infection of a host. We previously identified the bacterial species, Bordetella atropi, which uses nutrient-ind...

Expõem-se os fundamentos conceituais da contribuição de Niklas Luhmann à teoria social, segundo a qual a sociedade deve ser entendida como uma rede de operações e eventos constituída e mantida pela comunicação. ...

ABSTRACT Cancer is driven by genomic lesions and malignancy‐promoting transcriptional programs. In blood cancers, both are often interconnected as lesions frequently affect transcription factor (TF)‐encoding genes. T...

Abstract This study investigates changes in stress parameters in individuals with schizophrenia spectrum disorders participating in mindfulness-based group therapy (MBGT). N = 45 participants were randomised to MBGT ...

BackgroundGlutathione peroxidase 2 (GPX2) has a pivotal role in removing reactive oxygen species (ROS) from cells. Although the number of studies analyzing GPX2 in cancer is still limited, data suggesting a role of alter...

Multiple Sclerosis (MS) is a chronic neuroinflammatory autoimmune characterized by inflammation-induced lesion formation after immune cell infiltration into the central nervous system. T cells play an intriguing role in...

By applying a hybrid (kinetic ions and fluid electrons) simulation code, we study the plasma environment of Saturn's largest moon Titan during Cassini's T96 flyby on 1 December 2013. The T96 encounter marks the only obse...

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Polyphenol Oxidases (PPOs) catalyze the conversion of phenolic substrates to quinones, leading to the formation of dark-colored precipitates in fruits and vegetables. This process, known as enzymatic browning, is the cau...

Abstract Background Acquired narcolepsy has rarely been reported in veterinary medicine. Objective To describe the presentation, clinicopathological features, diagnostic imaging findings, and management of dogs with susp...

Based on a combination of in silico and cell biological analyses, this study suggests that the APOL1 variant p.N264K (M1) may prevent G2-mediated kidney toxicity by physically blocking ion flux. The APOL1 gene variants G...

As aviation's contribution to anthropogenic climate change is increasing, the sector aims at reducing its climate effect in accordance with international agreements. The strong and variable non-CO2 effects are complex, m...