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A growing interest in finding accessible and low-cost sources of melanin has emerged due to its wide range of applications. This work demonstrated the use of Mucuna deeringiana as a source of L-DOPA, and Solanum tuberosu...

Abstract Background Laccases (LACs) are multicopper oxidases that play vital roles in lignin polymerization, cell wall formation, and various stress responses in plants. Despite their importance, genome-wide investigatio...

Abstract Central carbon metabolism is thought to link reactive oxygen species (ROS) with antibiotic‐mediated bacterial death. During enrichment screening of Escherichia coli with the first‐generation quinolone oxolin...

Ethylene biosynthesis during postharvest ripening of tomato fruit is stimulated by the phytohormone abscisic acid (ABA). This research utilized mature green cherry tomato fruit to elucidate the molecular mechanism of SlA...

Abstract Many sulfated polysaccharides (SPSs) possess useful physicochemical properties and biological activities and are widely used in industry. Currently, major SPSs are derived from livestock and marine organisms. To...

Abstract Leptospirosis is a worldwide zoonosis caused by pathogenic bacteria of the genus Leptospira. Lipopolysaccharide (LPS) is an immunodominant and protective antigen for Leptospira, but its biosynthesis remains poor...

Abstract Polyunsaturated fatty acids (PUFAs) are important nutrients that play critical roles in sea urchin reproduction and early development. Strongylocentrotus intermedius, the only commercially cultured sea urchin sp...

Abstract Dietary fat absorption is among the most energy-demanding processes of nutrient uptake. Fatty acid activation, triglyceride synthesis, and the trafficking of chylomicrons through the secretory pathway - all requ...

Abstract Lilium brownii var. viridulum is rich in flavonoids, which offer antioxidant, anti-inflammatory, antitumor, and immunomodulatory effects. Recently, a novel, more resistant variant called L. brownii var. viridulu...

Triterpene saponins (TS) are a structurally diverse group of metabolites that are widely distributed in plants. They primarily serve as defense compounds and their production is often triggered by biotic stresses through...

Abstract Mycosporine‐like amino acids (MAAs) are natural sunscreens synthesized by a wide range of organisms. Although the induction of MAA production by ultraviolet radiation is well established, the signaling pathway...

IntroductionSiderophores are secondary metabolites with high affinity and specificity for iron and play a crucial role in iron acquisition. Vibrio fluvialis, an emerging foodborne opportunistic pathogen of increasing con...

Abstract The systematic exploration of novel bioactive compounds with superior functional properties is critical for driving innovations in agriculture, healthcare, and related fields, thereby becoming essential for adva...

One of the dominant features of the biology of Mycobacterium tuberculosis, and other mycobacteria, is the mycobacterial cell envelope with its exceptional complex composition. Mycolic acids are major and very specific co...

Abstract Background 3-Hydroxypropionic acid (3-HP) is a promising C3 platform chemical with wide industrial applications. However, its microbial production remains limited by insufficient intracellular malonyl-CoA availa...

The Phaffia rhodozyma UCD 67-385 genome harbors a 7873 bp cluster containing DDGS, OMT, and ATPG, encoding 2-desmethy-4-deoxygadusol synthase, O-methyl transferase, and ATPgrasp ligase, respectively, of the mycosporine g...

Abstract In response to concerns of environmental pollution caused by hazardous dyes, remediating these dyes is a challenge. Herein, we developed a genetic algorithm-artificial neural network (GA-ANN) based optimization ...

The net synthesis of sucrose (Suc) is catalysed by the sequential action of Suc-phosphate synthase (SPS) and Suc-phosphate phosphatase (SPP). SPS and SPP from Anabaena sp. PCC 7120 (7120-SPS and 7120-SPP) define minimal ...

Brazil’s rich biological legacy makes it a prime location for studying novel microbes due to its favorable characteristics, which support a wide range of biotechnological applications, including the synthesis of metall...

Abstract Background Vascular calcification is a major pathological process driving cardiovascular morbidity and mortality, yet effective therapies are lacking. This study aims to identify novel causal plasma proteins and...

Carbapenem resistance in the Gram-negative opportunistic pathogen Acinetobacter baumannii primarily stems from the overexpression of acquired class D serine β-lactamases, known as OXA carbapenemases. These enzymes exhib...

Exopolysaccharides (EPS) are high molecular weight biopolymers produced by a wide range of microorganisms, including lactic acid bacteria (LAB). These polymers can be secreted to the external environment (slime EPS) or a...

Abstract Background Tenacious glume a key trait limiting threshing efficiency in synthetic hexaploid wheat (SHW), represents an ancestral defense mechanism inherited from wild progenitors. Despite its evolutionary import...

Ganoderic acids (GAs), the major lanostane-type triterpenoids in Ganoderma lucidum (G. lucidum), possess diverse pharmacological activities but are produced at low levels, limiting their applications. Transcriptional reg...