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105 resultados encontrados.

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Synergistic effects of dexamethasone and vitamins D and K on mesenchymal stem cell differentiation
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Synergistic effects of dexamethasone and vitamins D and K on mesenchymal stem cell differentiation
Jana Dvorakova et al · BMC · 2026 · ISSN 1475-925X
Abstract Background The ability to guide stem cells toward the bone-forming lineage is a fundamental aspect of regenerative medicine. Conventional protocols for osteogenic differentiation of mesenchymal stem cells typica...
LCC TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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How exercise shapes the anti-inflammatory environment in multiple sclerosis – a conceptual framework focusing on tryptophan-derived molecules in T cell differentiation
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How exercise shapes the anti-inflammatory environment in multiple sclerosis – a conceptual framework focusing on tryptophan-derived molecules in T cell differentiation
Wences Chirino Tiffany Y. et al · De Gruyter · 2024 · ISSN 2942-6812
Multiple Sclerosis (MS) is a chronic neuroinflammatory autoimmune characterized by inflammation-induced lesion formation after immune cell infiltration into the central nervous system. T cells play an intriguing role in...
LCC LCC:Medicine; TENDOlNwb3J0cw~~Idioma eng
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Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota
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Interconnection of the Gut-Skin Axis in NC/Nga Mouse with Atopic Dermatitis: Effects of the Three Types of Bifidobacterium bifidum CBT-BF3 (Probiotics, Postbiotics, and Cytosine-Phosphate-Guanine Oligodeoxynucleotide) on T Cell Differentiation and Gut Microbiota
Gwang Il Kim et al · Springer Nature · 2024 · ISSN 2636-0772
Abstract The gut microbiota is an immune system regulator in the gut-skin axis. Dysfunctional interactions between the gut microbiota and the gut immune system can lead to the development of skin diseases such as atopic ...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
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Exploring cell differentiation, induced by inhibition of phospholipase C/protein kinase C cascade, as a potential therapeutic strategy against Rhabdomyosarcoma
Blanco, Nicolás Olegario et al · Scientific Archives · 2025 · ISSN 2692-8302
Among the reasons of childhood mortality, cancer is the leading cause ofdeath [1,2]. Of all paediatric cancers diagnosed, soft tissue sarcomas account for7%, of which approximately 50% are rhabdomyosarcoma (RMS), with an...
Idioma eng
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Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation
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Parenteral neonatal priming followed by heterologous mucosal booster favors IgM+ memory B cell induction over systemic plasma cell differentiation
Poorya Foroutan Pajoohian et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Early-life vaccinations often yield short-lived antibody (Ab) responses due to limited germinal center (GC) reaction and plasma cell (PC) survival. The aim of the study was to assess how vaccine delivery routes (homologo...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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The CARD11–BCL10–MALT1 (CBM) Complex Regulates Nutrient Transport and mTORC1 Activation to Shape CD4+ T Cell Differentiation
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The CARD11–BCL10–MALT1 (CBM) Complex Regulates Nutrient Transport and mTORC1 Activation to Shape CD4+ T Cell Differentiation
Allison Ruchinskas et al · Rockefeller University Press · 2026 · ISSN 3065-8993
IntroductionThe precise mechanisms linking TCR-dependent nutrient import and metabolic reprogramming to CD4+ T helper (Th) fate and function remain elusive. Here, we show that the CARD11–BCL10–MALT1 (CBM) complex fac...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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The L-Ascorbic Acid Increases Proliferation and Differentiation of Yanbian Cattle Skeletal Muscle Satellite Cells by Activating the Akt/mTOR/P70S6K Signaling Pathway
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The L-Ascorbic Acid Increases Proliferation and Differentiation of Yanbian Cattle Skeletal Muscle Satellite Cells by Activating the Akt/mTOR/P70S6K Signaling Pathway
Huaina Jin et al · Springer Nature · 2025 · ISSN 2636-0772
Abstract Cell-cultured meat, as a new type of meat food, can effectively mitigate the negative effects of conventional animal husbandry on the environment, health, and animal welfare. Muscle stem cells are the main seed ...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cells in vitro and in vivo
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Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cells in vitro and in vivo
Naujok, Ortwin et al · John Wiley & Sons Ltd · 2009 · ISSN 1520-7552
Background: Embryonic stem (ES) cells have the potential to produce unlimited numbers of surrogate insulin-producing cells for cell replacement therapy of type 1 diabetes mellitus. The impact of the in vivo environment o...
Idioma eng
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Dose-dependent effects of Metformin on proliferation and odontogenic differentiation of dental pulp stem cells
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Dose-dependent effects of Metformin on proliferation and odontogenic differentiation of dental pulp stem cells
Rania Rashad Omar Omar Taha et al · BMC · 2026 · ISSN 1472-6831
Abstract Background Metformin has emerged as a potential bioactive agent in regenerative medicine; however, its optimal concentration for enhancing dental pulp stem cell (DPSC) function remains unclear. This study evalua...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Laminin as a Key Extracellular Matrix for Proliferation, Differentiation, and Maturation of Porcine Muscle Stem Cell Cultivation
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Laminin as a Key Extracellular Matrix for Proliferation, Differentiation, and Maturation of Porcine Muscle Stem Cell Cultivation
Minsu Kim et al · Springer Nature · 2024 · ISSN 2636-0772
Abstract Extracellular matrix (ECM) proteins play a crucial role in culturing muscle stem cells (MuSCs). However, there is a lack of extensive research on how each of these proteins influences proliferation and different...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Pulsed electromagnetic field drives osteogenic and suppresses adipogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin signaling to ameliorate osteoporosis
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Pulsed electromagnetic field drives osteogenic and suppresses adipogenic differentiation of bone marrow mesenchymal stem cells via Wnt/β-catenin signaling to ameliorate osteoporosis
Jian Wei et al · Elsevier · 2026 · ISSN 2352-1872
A pathological shift in bone marrow mesenchymal stem cell (BMSC) differentiation towards adipogenesis at the expense of osteogenesis is a key cellular driver of osteoporosis induced by glucocorticoids or estrogen deficie...
LCC LCC:Diseases of the musculoskeletal systemIdioma eng
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Interplay between microRNAs and TGF-β signaling in T cells: implications for Th9 differentiation and immune pathogenesis
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Interplay between microRNAs and TGF-β signaling in T cells: implications for Th9 differentiation and immune pathogenesis
Tae Sung Kim et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Since the discovery of microRNAs (miRNAs) in 1993, they have been established as key post-transcriptional regulators of immune cell function. In particular, miRNAs have emerged as key modulators of CD4+ T cell activation...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats
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Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats
L.P. Romão et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2024 · ISSN 1678-4162
ABSTRACT This study aimed to compare the chondrogenic differentiation potential between bone marrow mesenchymal stem cells from female (fBMSCs) and male (mBMSCs) Wistar rats. For this purpose, female and male BMSCs were ...
LCC LCC:Animal cultureIdioma eng
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DS96432529 enhances osteogenic differentiation and mitigates inflammatory damage in periodontal ligament stem cells involving mitophagy-related processes
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DS96432529 enhances osteogenic differentiation and mitigates inflammatory damage in periodontal ligament stem cells involving mitophagy-related processes
Haipeng He et al · BMC · 2026 · ISSN 1757-6512
Abstract Aim Periodontitis can impair the osteogenic function of periodontal ligament stem cells (PDLSCs), thereby compromising their capacity for periodontal tissue regeneration. In this study, we explored the impact of...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~; TENDOkJpb2NoZW1pc3RyeQ~~Idioma eng
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Effect of Chicken Age on Proliferation and Differentiation Abilities of Muscle Stem Cells and Nutritional Characteristics of Cultured Meat Tissue
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Effect of Chicken Age on Proliferation and Differentiation Abilities of Muscle Stem Cells and Nutritional Characteristics of Cultured Meat Tissue
Chan-Jin Kim et al · Springer Nature · 2024 · ISSN 2636-0772
Abstract This study aimed to investigate effects of chicken age on proliferation and differentiation capacity of muscle satellite cells (MSCs) and to determine total amino acid contents of cultured meat (CM) produced. Ch...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Engineering a 3D matrix from porcine plasma for enhanced cell proliferation and differentiation
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Engineering a 3D matrix from porcine plasma for enhanced cell proliferation and differentiation
Yangyang Ma et al · Frontiers Media S.A · 2026 · ISSN 2297-1769
IntroductionThe limited availability of suitable scaffolds for three-dimensional (3D) cell culture has driven the development of new biomaterials. In this study, we developed a porcine fibrin matrix gel (PFMG) derived en...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Protein Kinase R-like Endoplasmic Reticulum Kinase-Mediated ER-Mitochondria Coupling Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells Under Inflammatory Stimuli
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Protein Kinase R-like Endoplasmic Reticulum Kinase-Mediated ER-Mitochondria Coupling Regulates Odontogenic Differentiation of Human Dental Pulp Stem Cells Under Inflammatory Stimuli
Yiqing Wang et al · Elsevier · 2026 · ISSN 0020-6539
Introduction and aims: Human dental pulp stem cells (hDPSCs) play pivotal roles in the regeneration of pulp-dentin complex, yet their odontogenic differentiation is critically modulated by the inflammatory microenvironme...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Roles of Hedgehog signaling pathway in adipogenic differentiation potential of porcine adipose-derived mesenchymal stem cells
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Roles of Hedgehog signaling pathway in adipogenic differentiation potential of porcine adipose-derived mesenchymal stem cells
Caiyun Fan et al · Sociedade Brasileira de Zootecnia · 2018 · ISSN 1806-9290
ABSTRACT This study examined the effects of purmorphamine and cyclopamine, classical agonists and inhibitors of the Hedgehog (Hh) signaling pathway, in the adipogenic differentiation of porcine adipose-derived mesenchyma...
LCC LCC:Animal cultureIdioma eng
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miR-326 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by targeting NAT10
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miR-326 promotes osteogenic differentiation of bone marrow mesenchymal stem cells by targeting NAT10
Yuanbin Zhang et al · BMC · 2026 · ISSN 1749-799X
Abstract Objectives Abnormal osteogenic differentiation of BMSCs is a core factor in osteoporosis (OP). This study investigates how miR-326 regulates osteogenic differentiation of hBMSCs by targeting NAT10, thereby influ...
LCC TENDOk9ydGhvcGVkaWMgc3VyZ2VyeQ~~; LCC:Diseases of the musculoskeletal systemIdioma eng
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Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells
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Melanocortin-receptor 4 activation modulates proliferation and differentiation of rat postnatal hippocampal neural precursor cells
Carniglia, Lila et al · Pergamon-Elsevier Science Ltd · 2024 · ISSN 0028-3908
Postnatal hippocampal neurogenesis is essential for learning and memory. Hippocampal neural precursor cells (NPCs) can be induced to proliferate and differentiate into either glial cells or dentate granule cells. Notably...
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Novel vanadium-loaded ordered collagen scaffold promotes osteochondral differentiation of bone marrow progenitor cells
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Novel vanadium-loaded ordered collagen scaffold promotes osteochondral differentiation of bone marrow progenitor cells
Cortizo, Ana María et al · Hindawi Publishing Corporation · 2016 · ISSN 1687-8795
Bone and cartilage regeneration can be improved by designing a functionalized biomaterial that includes bioactive drugs in a biocompatible and biodegradable scaffold. Based on our previous studies, we designed a vanadium...
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Transgenic high expression of EphB4 in canine periodontal ligament stem cells modulates osteogenic differentiation and migration in cPDLSCs
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Transgenic high expression of EphB4 in canine periodontal ligament stem cells modulates osteogenic differentiation and migration in cPDLSCs
Chang Shun Li et al · BMC · 2026 · ISSN 1475-925X
Abstract Background Signaling molecules play a critical role in regulating stem cell-mediated bone regeneration. In this study, we investigated the effect of EphB4 gene transfection on the osteogenic differentiation and ...
LCC TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Immunophenotyping, plasticity tests and nanotagging of stem cells derived from adipose tissue of wild rodent agouti (Dasyprocta prymnolopha)
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Immunophenotyping, plasticity tests and nanotagging of stem cells derived from adipose tissue of wild rodent agouti (Dasyprocta prymnolopha)
A.R. Rocha et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2019 · ISSN 1678-4162
ABSTRACT There is a growing interest in the study of unspecialized mesenchymal stem cells, for there are still some discussions about their in vitro behavior. Regenerative medicine is a science undergoing improvement whi...
LCC LCC:Animal cultureIdioma eng
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MZB1 Drives Periodontitis via ER Stress-Mediated Inflammation and Osteogenic Differentiation
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MZB1 Drives Periodontitis via ER Stress-Mediated Inflammation and Osteogenic Differentiation
Fei Ge et al · Elsevier · 2026 · ISSN 0020-6539
Introduction and aims: Increasing evidence suggests that marginal zone B and B1 cell-specific protein (MZB1) plays crucial roles in inflammatory responses, endoplasmic reticulum (ER) stress, and cell survival, but its fu...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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