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Bisphenol A (BPA) can combine with glycidyl methacrylate to form bisphenol A glycidyl methacrylate (Bis-GMA). Bis-GMA is an important industrial raw material and a significant component of dental resin materials. Althoug...

Craniofacial morphogenesis is a highly coordinated developmental process governed by complex genetic and molecular interactions. Among these, the PAX family of transcription factors plays a pivotal role in the regulation...

Advances in perinatal and neonatal medicine have dramatically improved the survival rates of infants with perinatal vulnerabilities of preterm birth (PTB), low birth weight (LBW) or small for gestational age (SGA), by re...

Vadim Tashlykov,1 Ruth Gur,2 Gabriel Ricardo Lichtenstein,2 Itay Goor-Aryeh,2 Evgeni Brotfain3 1Department of Anesthesiology, Pain Clinic, Samson University Medical Center, Public Hospital Assuta, Ashdod, Israel; 2Depart...

Introduction and aims: Submucous cleft palate (SMCP) is a congenital craniofacial malformation. While TBX22 is a known pathogenic gene, the potential role of TBX15 in SMCP remains unclear. This study aimed to investigate...

HELIOS is an IKAROS-family zinc-finger transcription factor that plays an important role in regulatory T cell function and conventional T cell homoeostasis. HELIOS shares a conserved N-terminal DNA-binding and C-terminal...

IntroductionKabuki syndrome (KS) is a rare, complex, multisystem, neurodevelopmental congenital disorder with characteristic phenotypic anomalies and pathogenic genetic variants of the KMT2D or KDM6A genes. KS is highly ...

Introduction and aims: Skeletal Class II malocclusion is heterogeneous, and conventional two-dimensional cephalometry may not fully capture relevant three-dimensional (3D) craniofacial variation. This study aimed to iden...

Abstract Parathyroid hormone 1 receptor (PTH1R) signaling is critical for mineral ion homeostasis and skeletal development. Although its role in tooth root formation and eruption is established, its specific functions in...

Nonsyndromic orofacial clefts (NSOC) are common congenital craniofacial developmental defects. Current evidence suggests that genetic factors, environmental exposures, and their interactions jointly contribute to the dev...