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Application of NgAgo-mediated genome editing in Mycobacterium smegmatis
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Application of NgAgo-mediated genome editing in Mycobacterium smegmatis
Li Zhao et al · American Society for Microbiology · 2025 · ISSN 0021-9193
ABSTRACT Mycobacterium smegmatis is nonpathogenic and fast-growing and is usually used as a model species of Mycobacterium. Studying basic metabolic mechanisms is crucial for accelerating mycobacterial research. Although...
LCC LCC:MedicineIdioma eng
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Reconstructing the complex architecture of the genome with molecular scissors: applying genome editing technology in precision medicine
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Reconstructing the complex architecture of the genome with molecular scissors: applying genome editing technology in precision medicine
Md Nur Amin Khan et al · Frontiers Media S.A · 2026 · ISSN 2673-3439
Our past, present, and future are governed by the grand design of the genetic blueprint, which was mapped more than two decades back. While the eloquent design of our genome results from millions of years of evolution a...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma eng
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Reduced Enzymatic Browning in Potato Tubers by Specific Editing of a Polyphenol Oxidase Gene via Ribonucleoprotein Complexes Delivery of the CRISPR/Cas9 System
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Reduced Enzymatic Browning in Potato Tubers by Specific Editing of a Polyphenol Oxidase Gene via Ribonucleoprotein Complexes Delivery of the CRISPR/Cas9 System
Gonzalez, Matías Nicolás et al · Frontiers Media · 2020 · ISSN 1649-1658
Polyphenol Oxidases (PPOs) catalyze the conversion of phenolic substrates to quinones, leading to the formation of dark-colored precipitates in fruits and vegetables. This process, known as enzymatic browning, is the cau...
Idioma eng
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The role of track changes in enhancing editing accuracy: Disentangling tool effect and metacognitive learning processes in academic manuscript editing
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The role of track changes in enhancing editing accuracy: Disentangling tool effect and metacognitive learning processes in academic manuscript editing
Meilan Arsanti et al · Universitas Ahmad Dahlan · 2026 · ISSN 0215-4994
While the digitization of academic editing is often considered to linearly improve performance, the internal mechanisms that differentiate the impact of tools and learning processes are rarely explored. This study aims t...
LCC TENDOkVkdWNhdGlvbiAoR2VuZXJhbCk~; LCC:Language and LiteratureIdioma eng
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Bespoke Base and Prime Editing Approaches for STING-Associated Vasculopathy with Onset in Infancy (SAVI)
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Bespoke Base and Prime Editing Approaches for STING-Associated Vasculopathy with Onset in Infancy (SAVI)
Enrico Drago et al · Rockefeller University Press · 2026 · ISSN 3065-8993
IntroductionSTING-associated vasculopathy with onset in infancy (SAVI) is a rare, severe type I interferonopathy caused by gain-of-function mutations in STING1, leading to early-onset systemic inflammation, cutaneous vas...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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On-Demand Personalized Gene Editing to Treat IRF4 p.T95A Immunodeficiency
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On-Demand Personalized Gene Editing to Treat IRF4 p.T95A Immunodeficiency
Vasil Toskov et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundOn-demand gene editing of autologous cells offers a novel therapeutic option for inborn errors of immunity (IEIs) caused by dominant-negative variants, which are often poorly addressed by conventional viral gen...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Gene Therapy Using Recombinant Adeno-Associated Virus for Leber Congenital Amaurosis Induced by RPE65 Mutation
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Gene Therapy Using Recombinant Adeno-Associated Virus for Leber Congenital Amaurosis Induced by RPE65 Mutation
Owliaee I et al · Dove Medical Press · 2026 · ISSN 1177-5483
Iman Owliaee,1 Ali Teimoori,1 Mohammad Shoushtari,2 Ali Shojaeian3 1Department of Medical Virology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran; 2Department of Virology, Pasteur Institute o...
LCC TENDOk9waHRoYWxtb2xvZ3k~Idioma eng
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A Systematic and Narrative Review of Safety and Complications in Minimally Invasive Glaucoma Surgery (MIGS) Between 2014–2024 [Letter]
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A Systematic and Narrative Review of Safety and Complications in Minimally Invasive Glaucoma Surgery (MIGS) Between 2014–2024 [Letter]
Nagy ZZ et al · Dove Medical Press · 2026 · ISSN 1177-5483
Zoltan Z Nagy,1 Kinga Kranitz,1 Iqbal Ike K Ahmed,2,3 Ticiana De Francesco,2,4 Eric Mikula,5,6 Tibor Juhasz5–7 1Department of Ophthalmology, Semmelweis University, Budapest, Hungary; 2John Moran Eye Center, Uni...
LCC TENDOk9waHRoYWxtb2xvZ3k~Idioma eng
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Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective
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Epigenetic signatures and cellular stress response pathways in metabolic dysfunction-associated steatotic liver disease: a personalized medicine perspective
Fabian M. Cortés-Mancera et al · Frontiers Media S.A · 2026 · ISSN 1664-042X
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease around the world, with at least 40% global prevalence. Although genetic susceptibility contributes to disease risk...
LCC TENDOlBoeXNpb2xvZ3k~Idioma eng
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Optimizing next-generation CAR-macrophages against solid tumors: challenges and potential strategies
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Optimizing next-generation CAR-macrophages against solid tumors: challenges and potential strategies
Yizhao Chen et al · BMC · 2026 · ISSN 1756-8722
Abstract Chimeric antigen receptor macrophage (CAR-M) therapy has emerged as a highly promising novel platform in solid tumor immunotherapy. Leveraging its inherent tumor-homing capacity, potent phagocytic function, and ...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBibG9vZCBhbmQgYmxvb2QtZm9ybWluZyBvcmdhbnM~; TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHIdioma eng
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Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma
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Pancancer Fine‐Mapping of Mutational Intolerance Identifies CHEK1 as an Immunosuppressive Driver in Lung Adenocarcinoma
Tao Wang et al · Wiley · 2026 · ISSN 2198-3844
ABSTRACT Mutation‐intolerant genes (MIGs), which are constrained in tumors yet variable in normal tissues, are critical for cancer survival. Herein, we developed miDriver, a computational framework using pancancer‐no...
LCC TENDOlNjaWVuY2U~Idioma eng
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A First-in-Human Base Edit Gene Therapy for CD40L Deficiency X-Linked Hyper IgM (XHIGM) Syndrome
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A First-in-Human Base Edit Gene Therapy for CD40L Deficiency X-Linked Hyper IgM (XHIGM) Syndrome
Suk See De Ravin et al · Rockefeller University Press · 2026 · ISSN 3065-8993
CD40L-deficient X-linked hyper IgM (XHIGM) syndrome is characterized by defective B cell class switching, deficiency of immunoglobulins G, A, and E, plus other immune abnormalities due to disrupted CD40L–CD40 interacti...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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A Fluorescence‐Based Transient Expression Assay for the Analysis of Upstream Open Reading Frames in Plants
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A Fluorescence‐Based Transient Expression Assay for the Analysis of Upstream Open Reading Frames in Plants
Benjamin E. Haas et al · Wiley · 2026 · ISSN 2475-4455
ABSTRACT Upstream open reading frames (uORFs) are regulatory elements present in the 5′ leaders of mRNA that can significantly impact downstream gene expression in eukaryotes. In crop engineering, editing of uORFs can ...
LCC TENDOkJvdGFueQ~~Idioma eng
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CRISPR-based mutagenesis of lipopolysaccharide biosynthesis genes in Leptospira interrogans reveals gene essentiality and confirms the role of an O-antigen polymerase
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CRISPR-based mutagenesis of lipopolysaccharide biosynthesis genes in Leptospira interrogans reveals gene essentiality and confirms the role of an O-antigen polymerase
Luis G. V. Fernandes et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Leptospirosis is a worldwide zoonosis caused by pathogenic bacteria of the genus Leptospira. Lipopolysaccharide (LPS) is an immunodominant and protective antigen for Leptospira, but its biosynthesis remains poor...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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CRISPR-driven texture engineering: Redefining functional foods for precision nutrition and human health
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CRISPR-driven texture engineering: Redefining functional foods for precision nutrition and human health
Jacob Tizhe Liberty et al · Elsevier · 2026 · ISSN 1756-4646
Food texture is increasingly recognized as a determinant of nutritional safety, metabolic regulation, and overall health. However, conventional approaches to texture modification rely primarily on hydrocolloids, mechanic...
LCC LCC:Nutrition. Foods and food supplyIdioma eng
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Cyber Security Threats of Using Generative Artificial Intelligence in Source Code Management
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Cyber Security Threats of Using Generative Artificial Intelligence in Source Code Management
Sainag Nethala et al · MMU Press · 2025 · ISSN 2821-370X
Generative Artificial Intelligence (Generative AI) models are now broadly used for academic writing and software development for the sake of productivity and efficiency. Concerns on the impact of Artificial Intelligence ...
LCC LCC:Electronic computers. Computer science; TENDOkluZm9ybWF0aW9uIHRlY2hub2xvZ3k~Idioma eng
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Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models
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Deciphering the Impact of RAC1‐SPTAN1 in ARPKD Cystogenesis Using Multifaceted Models
Shohei Kuraoka et al · Wiley · 2026 · ISSN 2198-3844
ABSTRACT Autosomal recessive polycystic kidney disease (ARPKD) leads to severe renal cysts and progressive kidney dysfunction, with no approved treatments. The absence of such cystic phenotypes in Pkhd1−/− mice under...
LCC TENDOlNjaWVuY2U~Idioma eng
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Decreases in polyunsaturated fatty acid content improve heat stress tolerance during flowering and silicle development in pennycress (Thlaspi arvense L.)
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Decreases in polyunsaturated fatty acid content improve heat stress tolerance during flowering and silicle development in pennycress (Thlaspi arvense L.)
Nikhil S. Jaikumar et al · Frontiers Media S.A · 2026 · ISSN 1664-462X
IntroductionPennycress (Thlaspi arvense L.) is an emerging intermediate oilseed crop grown in the offseason between primary summer crops to produce three cash crops in two years. Previous efforts to improve seed oil qual...
LCC TENDOlBsYW50IGN1bHR1cmU~Idioma eng
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Development of Communicative Competence of Future Special Education Teachers
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Development of Communicative Competence of Future Special Education Teachers
Tetiana Kachak et al · Vasyl Stefanyk Carpathian National University · 2023 · ISSN 2311-0155
The article highlights the peculiarities of the development of communicative competence of future teachers of special education in the context of their professional training. It is noted that communicative competence is ...
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EPInformer: scalable and integrative prediction of gene expression from promoter-enhancer sequences with multimodal epigenomic profiles
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EPInformer: scalable and integrative prediction of gene expression from promoter-enhancer sequences with multimodal epigenomic profiles
Jiecong Lin et al · Nature Portfolio · 2026 · ISSN 2041-1723
Abstract Transcriptional regulation, critical for cellular differentiation and adaptation to environmental changes, involves coordinated interactions among DNA sequences, regulatory proteins, and chromatin architecture. ...
LCC TENDOlNjaWVuY2U~Idioma eng
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Effect of mitochondrial dysfunction on scar formation after spinal cord injury
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Effect of mitochondrial dysfunction on scar formation after spinal cord injury
Yuchen Zhang et al · Frontiers Media S.A · 2026 · ISSN 1664-2295
Spinal cord injury (SCI) triggers a cascade of primary and secondary pathological events that culminate in the formation of glial and fibrotic scars, which constitute a major barrier to axonal regeneration and functional...
LCC LCC:Neurology. Diseases of the nervous systemIdioma eng
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
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Epigenetic modifications in cancer drug resistance: molecular mechanisms and therapeutic interventions
Jingyi Yang et al · Springer · 2026 · ISSN 2662-8651
Abstract Therapeutic resistance remains a major cause of treatment failure and disease recurrence across cancer types, considerably limiting the long-term efficacy of chemotherapies, targeted therapies, and immunotherapi...
LCC LCC:MedicineIdioma eng
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Explainable detection of machine generated music and early systematic evaluation
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Explainable detection of machine generated music and early systematic evaluation
Yupei Li et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Machine-generated music (MGM) has become a groundbreaking innovation with wide-ranging applications, such as music therapy, personalised editing, and creative inspiration within the music industry. However, the ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Fatores de correção de escores visuais de conformação, precocidade e musculatura, à desmama, para idade da vaca ao parto, data juliana de nascimento e idade à desmama em bovinos da raça Nelore Conformation, precocity and musculature visual scores adjustment factors for age of dam at calving, Julian date of birth and age of calf at weaning, in Nelore cattle breed
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Fatores de correção de escores visuais de conformação, precocidade e musculatura, à desmama, para idade da vaca ao parto, data juliana de nascimento e idade à desmama em bovinos da raça Nelore Conformation, precocity and musculature visual scores adjustment factors for age of dam at calving, Julian date of birth and age of calf at weaning, in Nelore cattle breed
João Jorge Júnior et al · Sociedade Brasileira de Zootecnia · 2004 · ISSN 1516-3598
Neste estudo, após a edição dos dados, foram utilizadas 87.372 informações de escores visuais de conformação (C), precocidade (P) e musculatura (M) à desmama de animais Nelore, provenientes de rebanhos comerciais...
LCC LCC:Animal cultureIdioma eng
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