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Matrix metalloproteinases (MMPs) are a family of zinc dependent proteinases and the main promoters of extracellular matrix degradation. Their role in renal diseases is now being understood better. Several progressive ren...

Cancer cells have an altered metabolism that increases acid production driving to an extracellular pH significantly lower than normal. This leads to normal cell death, and extracellular matrix degradation allowing the fo...

Amyloidosis is a disorder characterized by accumulation of B sheet misfolded proteinosis, amorph material at extracellular matrix. Amyloidosis is a serious disease that can cause mortality and severe morbidity with organ...