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In recent years, the search for new anticancer drugs from local plants in Indonesia has become an interesting topic for research. One of the typical Indonesian local plants that have been used by the community as an anti...

Abstract Three chromophores 5a-c based on the diphenylamine (donor), thiazole (π-core) and acrylonitrile (acceptor) were synthesized and characterized by IR, NMR, MS analyses. The donor–acceptor chromophores 5a-c were...

Long noncoding RNAs (lncRNAs) have emerged as critical regulators of plant development, physiology, and environmental stress adaptation. Despite exhibiting limited primary sequence conservation across the plant kingdom, ...

Empasiprubart (ARGX-117) is a humanized recycling antibody that prevents binding of C2 to C4b, blocking downstream classical and lectin pathways of complement activation. Empasiprubart binds to the CCP2 domain of complem...

Nanoscale particles and structures hold promise in circular dichroism (CD) spectroscopy for overcoming the weakness of molecular CD signals. Significant effort have been made to characterize nanophotonic CD enhancement a...

Abstract Fungal inositol phosphorylceramide (IPC) synthase is an essential enzyme complex that catalyzes a critical step in sphingolipid biosynthesis. It is the molecular target of potent antifungal aureobasidin A (AbA)....

Red blood cells (RBCs), formerly viewed as mere oxygen transporters, are now acknowledged as dynamic biological entities with intricate molecular characteristics which impact their deformability, lifespan, and interactio...

Abstract Recently, interest in food-derived bioactive peptides as promising ingredients for the prevention and improvement of hypertension is increasing. The purpose of this study was to determine the structure and antih...

STAT1 gain-of-function (GoF) is an inborn error of immunity characterized by a common feature of chronic mucocutaneous candidiasis and variable additional clinical manifestations, including recurrent bacterial and viral ...

Fluorinated ether-based electrolytes represent a promising avenue for improving lithium-ion battery performance and safety, yet the molecular mechanisms governing ion transport in these systems remain insufficiently unde...

Tripartite motif (TRIM)7 is an E3 ubiquitin ligase that was first identified through its interaction with glycogenin-1 (GN1), the autoglucosyltransferase that initiates glycogen biosynthesis. A growing body of evidence i...

Abstract Poly (ADP-ribose) polymerase-1 (PARP-1) is an enzyme that plays a pivotal role in DNA repair and the maintenance of genomic stability. The discovery of synthetic lethality in tumors with homologous recombination...

1-(acyl/aroyl)-3-(substituted)thioureas are exciting structures in the fields of organic synthesis, material sciences, and biomedical research. Of particular significance is the fact that acyl thiourea derivatives have b...

Abstract Generative artificial intelligence is reshaping how researchers discover protein-binding compounds and develop them into drug candidates. Unlike traditional methods that screen existing molecules, structure-base...

Identification of defects in crystalline structures is of vital importance when describing the plastic behavior of metals. Despite the increasing number of tools available in the literature, additional techniques are sti...

The molecular structure and conformational properties of 2,2,2-trichloroethyl chloroformate, ClC(O)OCH2CCl3 were determined experimentally using gas-phase electron diffraction (GED) and theoretically based on quantum-che...

Observations of molecular structures on scales of ∼0.1−50 pc show that the specific angular momentum ( j ) scales with radius ( R ) as j  ∼  R ^3/2 . We study the effects of turbulence, gravity, and the magnetic ...

In some regions of Argentina and Brazil, the South American fruit fl y Anastrepha fraterculus (Wied.) (Diptera: Teph-ritidae) causes significant damage to crops. An efficient integrated management program requires knowle...

ABSTRACT Antiferroelectrics (AFEs) with typical reversible electrically antipolar‐polar phase transformation have attracted tremendous attention for assembling electronic devices. As a thriving part of the family, mole...

Interest in electron diffraction (ED) for structural characterization of both proteins and small molecules has grown significantly over the last decade. While ab initio phasing methods remain the gold standard for ED dat...

Six new uranyl hybrid materials have been synthesized solvothermally utilizing the ligands 2,2′-bipyridine-3,3′-dicarboxylic acid (H2L) and 2,2′:6′,2′′-terpyridine (TPY). The six compounds are classified as e...

Abstract Phase separation (PS) of biomolecular condensates is often assumed to be driven by interactions involving nucleic acids and intrinsically disordered regions (IDRs) of proteins. PGL-3 is a component of P granules...

In this study, the characteristics of phonon transport in single-crystal and nanograined zirconium diboride have been examined using the molecular dynamics method. In the case of single-crystal ZrB2 the anisotropy of the...

The short-range order structure of the Zr47,5Cu47,5Al5 and Zr40Cu40Al20 melts   was investigated by the method of molecular dynamics simulations. Based on the obtained results, partial pair correlation functions and di...