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Background and AimsThe primary focus of neonatal screening is the early detection of asymptomatic infants with a range of serious diseases for which effective treatment is available and for which early diagnosis and inte...

Chronic renal failure (CRF) is defined as a serum creatinine above 1mg/dl in the 1st year of life, which corresponds to creatinine clearances below 30ml/min per 1.73m². CRF is rarely seen in the newborn period. Acco...

Abstract Global strategies to improve newborn survival have expanded from basic Essential Newborn Care practices to more comprehensive approaches that address the specific needs of small and sick newborns. Despite advanc...

OBJETIVOS: comparar a incidência de partos pré-termos e de recém-nascidos de baixo peso entre adolescentes primíparas de duas faixas etárias. MÉTODOS: estudo clínico, comparativo e transversal, cuja amostra é com...

The diagnosis of urinary tract infection (UTI) is difficult in the newborn period since the signs and symptoms of UTI are nonspecific in this age group. Urinary tract infection in infancy may lead to renal scars and if i...

Introduction: Hypocalcaemia is very common in sick newborns and is frequently associated with severe Vitamin D Deficiency (VDD). VDD can lead to both acute and long-term complications in newborns. Estimating vitamin D le...

A introdução da profilaxia da transmissão vertical do HIV com o uso de drogas anti-retrovirais aliadas a outras medidas resultou na redução de crianças infectadas pelo HIV em nosso meio. Esses medicamentos são de ...

ABSTRACT The aim of this study was to evaluate newborn foals stress in the first 48 hours of life. Heart rate (HR), heart rate variability (HRV) and serum cortisol concentrations, blood glucose, and lactate were determin...

Background: Neonatal hyperbilirubinemia is a common condition and a major contributor to neonatal morbidity, particularly among infants from multifetal pregnancies who are at increased risk due to prematurity and low bir...

BackgroundSevere combined immunodeficiency (SCID) is a life-threatening condition that requires urgent medical attention. Newborn screening (NBS) using the T cell receptor excision circle (TREC) assay facilitates early d...

Introduction Newborns who are born too soon, too small or sick are a vulnerable group who require special/high-dependency/intensive care after birth. Infant and Family-Centred Developmental Care (IFCDC) is an integrated ...

DNA ligase IV (LIG4) is essential for repairing breaks in double-stranded DNA via nonhomologous end-joining in developing lymphocytes and is particularly important for V(D)J recombination. First described in the early 20...

IntroductionLow T cell receptor excision circles (TRECs) on newborn screen and severe T cell lymphopenia in a term newborn raise concern for severe combined immunodeficiency (SCID). Genetic polymorphisms in thiopurine me...

Abstract Despite a proliferation of the United Nations General Assembly high-level meetings on a range of health issues and developmental challenges, global funding continues to flow disproportionately to HIV and materna...

BackgroundT cell receptor excision circle (TREC)-based newborn screening (NBS) for severe combined immunodeficiency (SCID) has improved early diagnosis, treatment, and survival of SCID infants and identified additional c...

BackgroundGlucose-6-phosphate dehydrogenase (G6PD) provides the main cellular source of NADPH through the pentose phosphate pathway, supporting antioxidant defenses and metabolic programs required for hematopoietic devel...

Background Parental knowledge of newborn care is essential, as it can influence the newborn’s health, growth, and development. It is challenging due to a lack of mothers’ knowledge and skills, insufficient resources,...

Abstract Objective Evaluate the prevalence of macrosomic newborns (birth weight above 4000 grams) in a high-risk maternity from 2014 to 2019, as well as the maternal characteristics involved, risk factors, mode of deli...

Introduction The obstetric complications remain the leading cause of death in women of reproductive age and their neonates in low and middle-income countries. These deaths are largely preventable through providing qualit...

ABSTRACT Background Sepsis has been defined in humans as the concurrent proven or suspected presence of microbial infection and the systemic inflammatory response syndrome (SIRS). Sepsis is the leading cause of morbidity...

Longitudinal profiling of 136 newborns shows thymic output peaks at 3–4 mo, correlating with plasma RANKL, lymphotoxin-α, and the TCRD variant rs2204985. In thymic tissue, RANKL tracks medullary—but not cortical—e...

Foi avaliado o efeito das gemas de ovos de aves hiperimunizadas contra Escherichia coli (E. coli) patogênica para suínos sobre a imunidade passiva de leitões recém-nascidos em uma unidade produtora de leitões. Foram...

Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major cause of intestinal disease and hemolytic uremic syndrome, a serious systemic complication that particularly affects children. Cattle are primary reservoirs fo...

Relata-se o caso de um bovino com, aproximadamente, seis horas de vida, apresentando histórico de febre, apatia, inapetência e desconforto ocular. No exame oftálmico rotineiro, encontraram-se valores do teste da lágr...