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43 resultados encontrados.

Tipos de recurso: Libro electrónico Artículo Revista Tesis Capítulo
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Chemical proteomics reveals sinomenine’s anti-inflammatory mechanism through serum protein covalent modification
Artículo
Material complementario disponible Artículo DOAJ
Meixian Liu et al · BMC · 2026 · ISSN 1749-8546
Abstract Background Covalent protein modification by drugs or their reactive metabolites has emerged as an important mechanism underlying pharmacological activity. However, its contribution to the therapeutic effects of ...
LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma eng
Material complementario disponibleEl enlace apunta a material asociado, anexos, tablas, datos o página complementaria. No se marca como libro/texto completo.
Material complementario
Complementary Muscle Metabolomics and Proteomics of Muscle in Cows With Post‐Calving Ketosis
Artículo
Acceso abierto Artículo DOAJ
Tao Tang et al · Oxford University Press · 2025 · ISSN 0891-6640
ABSTRACT Background The muscle tissue of dairy cows is a site of β‐hydroxybutyrate (BHBA) metabolism. The mechanisms underlying the changes in proteins and metabolites in the muscle tissue of cows with ketosis remain ...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
Acceso abiertoRuta libre sin proxy. Acceso recomendado cuando no hay suscripción activa.
Open Access
In silico comparative proteomics and structural analysis of Theileria species reveals conserved druggable targets for anti-theilerial therapy
Artículo
Material complementario disponible Artículo DOAJ
Hizbullah Khan et al · BMC · 2026 · ISSN 1471-2180
Abstract Theileriosis, a tick-borne disease caused by apicomplexan parasites of the genus Theileria, poses a major constraint to livestock productivity worldwide. Existing chemotherapeutics are increasingly limited by ho...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
Material complementario disponibleEl enlace apunta a material asociado, anexos, tablas, datos o página complementaria. No se marca como libro/texto completo.
Material complementario
Isobaric quantitative proteomics reveals altered extracellular matrix, cytoskeletal, and degradation pathways in glaucomatous trabecular meshwork cells
Artículo
Acceso abierto Artículo DOAJ
Paul Holden et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Glaucoma trabecular meshwork (GTM) cells cultured in vitro retain many characteristics of their in situ phenotype. Here, we used isobaric tandem mass tags (TMTpro) to label peptides from glaucomatous and non-gla...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Open Access
DSCAML1+ extracellular vesicles revealed by single-vesicle proteomics as a novel biomarker and therapeutic target in myocardial infarction
Artículo
Material complementario disponible Artículo DOAJ
Nan Liu et al · BMC · 2026 · ISSN 1477-3155
Abstract The early and accurate diagnosis of acute myocardial infarction (AMI) remains a significant clinical challenge. To this end, we profiled the surface proteome of individual plasma extracellular vesicles (EVs) fro...
LCC TENDOkJpb3RlY2hub2xvZ3k~; TENDOk1lZGljYWwgdGVjaG5vbG9neQ~~Idioma eng
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Integrated transcriptomics, proteomics, and metabolomics analyses reveal key regulatory pathways related to the development of viral symptoms in tomato plants
Artículo
Acceso abierto Artículo DOAJ
Kaijie Shang et al · BMC · 2026 · ISSN 1471-2229
Abstract Background Viral infections of tomato plants present a significant threat to tomato production and yield. Mixed viral infections are common in field-grown tomatoes and are known to exacerbate disease symptoms; h...
LCC TENDOkJvdGFueQ~~Idioma eng
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Open Access
Blood cell ratio biomarkers of systemic inflammation in chronic obstructive pulmonary disease
Artículo
Acceso abierto Artículo DOAJ
Kaman So et al · BMC · 2026 · ISSN 1465-993X
Abstract Background Blood eosinophil count is an accepted biomarker for type 2 inflammation in COPD. However, the majority of COPD patients are characterized by non-type 2 inflammation. We aimed to test readily obtainabl...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSByZXNwaXJhdG9yeSBzeXN0ZW0~Idioma eng
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Open Access
Extração e análise eletroforética em gel de poliacrilamida (SDS-PAGE) de proteínas totais de folhas e raízes de Piper tuberculatum Extraction and polyacrylamide gels electrophoresis analysis (SDS-PAGE) of total protein from leaves and roots of Piper tuberculatum
Artículo
Material complementario disponible Artículo DOAJ
Redinaldo dos Santos Silva et al · Instituto Nacional de Pesquisas da Amazônia · 2009 · ISSN 0044-5967
O Estado do Pará é o principal produtor brasileiro de pimenta-do-reino (Piper nigrum Link), entretanto a sua produção tem sido bastante afetada pela doença conhecida como fusariose. O Fusarium solani f. sp. piperis ...
LCC LCC:Science (General)Idioma eng
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Identification of candidate biomarkers for diagnosis, disease activity, and relapse prediction in IgG4-related disease
Artículo
Acceso abierto Artículo DOAJ
Qiyuan Hao et al · BMC · 2026 · ISSN 1478-6362
Abstract Objectives IgG4-related disease (IgG4-RD) is an immune-mediated condition with diagnostic challenges in clinical practice. Sensitive biomarkers are needed for diagnosis, disease activity and disease progression ...
LCC LCC:Diseases of the musculoskeletal systemIdioma eng
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Open Access
Multi-Omics Approaches to Improve Meat Quality and Taste Characteristics
Artículo
Acceso abierto Artículo DOAJ
Young-Hwa Hwang et al · Springer Nature · 2023 · ISSN 2636-0772
Abstract With rapid advances in meat science in recent decades, changes in meat quality during the pre-slaughter phase of muscle growth and the post-slaughter process from muscle to meat have been investigated. Commonly ...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Open Access
Proteome-assisted multi-feature discriminant modelling of chronic post-surgical pain in female patients: A proof-of-concept study
Artículo
Acceso abierto Artículo DOAJ
Simon Haroutounian et al · Elsevier · 2026 · ISSN 1096-1186
Pain after surgery is of major perioperative concern because it is associated with substantial complications, including chronic post-surgical pain (CPSP) development. The CPSP incidence is high, and its accurate predicti...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Open Access
Proteomic analysis of secretomes from Bacillus sp. AR03: characterization of enzymatic cocktails active on complex carbohydrates for xylooligosaccharides production
Artículo
Material complementario disponible Artículo CONICET Digital
Hero, Johan Sebastian et al · Taylor & Francis · 2021 · ISSN 1082-6068
Bacillus sp. AR03 have been described as an important producer of carbohydrate-active enzymes (CAZymes) when growing in a peptone-based medium supplemented with simple sugars and/or carboxymethyl cellulose (CMC) as carbo...
Idioma eng
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Material complementario
Proteomic landscape analysis of undifferentiated pleomorphic sarcoma
Artículo
Acceso abierto Artículo DOAJ
Biqiang Zheng et al · BMC · 2026 · ISSN 1756-994X
Abstract Background Proteins represent the dynamic downstream products of genes, and have the potential to substantially increase understanding of the complexities of cancer biology. Undifferentiated pleomorphic sarcoma ...
LCC LCC:Medicine; LCC:GeneticsIdioma eng
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Open Access
Immunoproteomic insights into inflammatory diseases of the critically endangered black rhinoceros (Diceros bicornis)
Artículo
Acceso abierto Artículo DOAJ
Molly L. Corder et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Black rhinoceros are critically endangered due to poaching in the wild (in situ). Globally, fewer than 200 animals are maintained as an ex situ insurance population. Unfortunately, the ex situ population faces m...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Open Access
Integrative multi-scale physiological, metabolic, and proteomic reprogramming in tomato under polyethylene microplastic stress
Artículo
Acceso abierto Artículo DOAJ
Young Sang Kwon et al · Elsevier · 2026 · ISSN 0147-6513
Microplastic (MP) contamination in agricultural soils is an emerging environmental hazard with poorly understood impacts on crops. Here, we investigated concentration-dependent effects of polyethylene MPs on tomato (Sola...
LCC LCC:Environmental pollution; TENDOkVudmlyb25tZW50YWwgc2NpZW5jZXM~Idioma eng
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Open Access
Proteomic Profiling of PTEN Inhibition on Periodontal Ligament Stem Cells
Artículo
Acceso abierto Artículo DOAJ
Suphalak Phothichailert et al · Elsevier · 2026 · ISSN 0020-6539
Objective: Phosphatase and tensin homolog (PTEN) is a critical regulator of cell proliferation, differentiation, and inflammatory balance. However, its downstream proteomic effects in periodontal ligament stem cells (PDL...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
Acceso abiertoRuta libre sin proxy. Acceso recomendado cuando no hay suscripción activa.
Open Access
Proteomic analysis reveals the molecular mechanisms of deoxynivalenol-induced injury in the jejunum of piglets
Artículo
Material complementario disponible Artículo DOAJ
Shuya Ma et al · BMC · 2026 · ISSN 1471-2164
Abstract Deoxynivalenol (DON), a prevalent Fusarium mycotoxin, poses a significant threat to intestinal health in piglets. This study established a deoxynivalenol (DON) intoxication model in piglets, revealing compromise...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma eng
Material complementario disponibleEl enlace apunta a material asociado, anexos, tablas, datos o página complementaria. No se marca como libro/texto completo.
Material complementario
Proteomic remodeling during tumor cell-induced platelet aggregation unveils metastatic drivers in colorectal cancer
Artículo
Material complementario disponible Artículo DOAJ
Thorben Sauer et al · BMC · 2026 · ISSN 1475-2867
Abstract Background Colorectal cancer (CRC) is frequently associated with metastasis, resulting in high mortality rates. Platelets are known to play a crucial role in the metastatic cascade influencing tumor microenviron...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~; LCC:CytologyIdioma eng
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Unravelling distinct proteome changes in two maize inbreds with contrasting stalk‐lodging resistance upon drought
Artículo
Acceso abierto Artículo DOAJ
Rocío C. Arce et al · Frontiers Media S.A · 2026 · ISSN 1664-462X
Stalk-lodging and drought are major constraints limiting maize productivity. We previously characterized B73 as stalk-lodging resistant but drought-sensitive maize inbred, while EA2024 is stalk-lodging susceptible and dr...
LCC TENDOlBsYW50IGN1bHR1cmU~Idioma eng
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Open Access
Vitamin D metabolites reshape bovine mammary epithelial responses relevant to mastitis through host-directed mechanisms
Artículo
Acceso abierto Artículo DOAJ
Georgina Tiraboschi et al · Frontiers Media S.A · 2026 · ISSN 2235-2988
IntroductionBovine mastitis remains one of the most prevalent diseases in dairy cattle and is largely managed through antibiotic therapy, which contributes to antimicrobial resistance. Host-directed strategies that enhan...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Open Access
Annexin A1 triggers autophagy to orchestrate radioiodine resistance in thyroid cancer via upregulating HMGB1
Artículo
Acceso abierto Artículo DOAJ
Xuehan Wang et al · BMC · 2026 · ISSN 1475-2867
Abstract Purpose This study aims to investigate the mechanisms underlying ANXA1 and HMGB1-regulated autophagy in relation to growth and radioresistance in thyroid cancer cells. This exploration seeks to provide new theor...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~; LCC:CytologyIdioma eng
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Open Access
Comparative analysis of venom genes in the chromosome-level genomes of two closely related cone snails
Artículo
Acceso abierto Artículo DOAJ
Ana Herráez-Pérez et al · BMC · 2026 · ISSN 1471-2164
Abstract Background Venom cocktails of cone snails are characterized by their dynamic composition and the rapid evolution of toxin-encoding genes due to various selective pressures. The integration of comparative genomic...
LCC TENDOkJpb3RlY2hub2xvZ3k~; LCC:GeneticsIdioma eng
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Open Access
Cytohesin-2 is essential for the perinatal development of mice and regulates Golgi volume
Artículo
Acceso abierto Artículo DOAJ
Carsten Küsters et al · Life Science Alliance LLC · 2026 · ISSN 2575-1077
The present study presents the first characterization of a full cytohesin-2 knockout and establishes cytohesin-2 as a critical factor for perinatal development, identifying a previously unrecognized role of cytohesin-2 i...
LCC LCC:Medicine; LCC:Biology (General)Idioma eng
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Open Access
Delphinidin, a dietary anthocyanidin, modulates PD-L1 and STING/TBK1 signaling and reprograms the immune microenvironment in triple-negative breast cancer
Artículo
Acceso abierto Artículo DOAJ
Haomou Pu et al · Elsevier · 2026 · ISSN 1756-4646
Triple-negative breast cancer (TNBC) exhibits genomic instability and rapidly upregulates PD-L1. This study investigated whether delphinidin, the dietary anthocyanidin, could modulate both intrinsic PD-L1 signaling and S...
LCC LCC:Nutrition. Foods and food supplyIdioma eng
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Open Access