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Abstract Background Sarcopenia, the age-related loss of muscle mass and strength, is a leading cause of disability and frailty in older adults. Though primarily seen as a musculoskeletal condition, emerging evidence sugg...

ObjectiveSarcopenia is a progressive and complex disorder associated with higher morbidity and mortality, which significantly increases the financial burden and medical costs. This study aims to investigate the relations...

BackgroundSarcopenia elevates risks of falls, hospitalization, and mortality in older adults. Despite protein’s importance for muscle maintenance, evidence on its overall and source-specific role in sarcopenia developm...

ObjectiveExcessive secretion of inflammatory biomarkers exerts adverse effects on muscle strength and function, and is associated with the development and progression of sarcopenia and frailty. For the improvement of inf...

BackgroundSarcopenia, an age-correlated decline in skeletal muscle mass and function, has been increasingly linked to ferroptosis, which is an iron-dependent form of regulated cell death driven by lipid peroxidation. Nev...

Abstract To determine the relationship between mucus plugging and CT-derived parameters of sarcopenia in routine chest CT-scans. Patients with advanced Chronic Obstructive Lung Disease (COPD GOLD 3 or 4) were investigate...

BackgroundSarcopenia has a high incidence in older patients with sepsis and is closely associated with poor prognosis, but its metabolic characteristics under this specific stress state remain unclear. This study aims to...

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BackgroundSarcopenia is a progressive, age-associated condition marked by loss of muscle mass, strength, and physical performance, representing a key nutritional and functional problem in aging people. This study examine...

Abstract Recently, protein-fortified milk powders are being widely consumed in Korea to prevent sarcopenia, and the demand for high-protein food powders is continuously increasing in the Korean market. However, spray-dri...

Ageing, immobilization, sepsis or cachexia reduce muscle mass and function. The age-related loss, i.e. sarcopenia, contributes to frailty and results in a loss of mobility and autonomy in aging and disease. Affected ind...

Abstract Background Sarcopenia is a muscle disease that increases the risk of falls, fractures, and mortality. Appendicular lean mass (ALM) assessment is central to its diagnosis, but standard methods like dual-energy X-...

Abstract Background Approximately 75% of hyperthyroid cats lose muscle mass as accessed with a muscle condition scoring (MCS) system. After treatment, MCS improves as the cats regain muscle mass. Objectives To quantify t...

Abstract Background Outcomes after curative-intent sarcoma surgery vary substantially and are incompletely explained by tumor-centered factors alone. Although CT-based body composition metrics provide objective host-rela...

Abstract Background Cancer treatments such as chemotherapy and radiotherapy significantly impact the cardiovascular system. While cardiac toxicity is well characterized, the effects on the aorta, the body’s largest art...

ABSTRACT Understanding how skeletal muscle influences bone formation is essential for uncovering the mechanisms of muscle‐bone communication and developing therapies for osteoporosis. Here, we demonstrate that extracel...

Abstract Background Intramuscular fat (IMF) accumulation in lumbar‑spine muscles is associated with sarcopenia, low‑back pain and poorer surgical outcomes. Dixon MRI allows the measurement of IMF with voxel-wise fat ...

Bangle belongs to the ginger family and has anti-inflammatory properties; however, its efficacy against skeletal muscle atrophy in ulcerative colitis (UC) remains unexplored. This study investigated the effects of Bangle...

Abstract Mitochondrial diseases progressively lead to multisystemic failure with treatment options remaining extremely limited. Here, to investigate strategies that alleviate mitochondrial dysfunction, we first generate ...

Abstract Sarcopenia, the age-related muscle atrophy, is a serious concern as it is associated with frailty, reduced physical functions, and increased mortality risk. Protein supplementation is essential for preserving mu...

ABSTRACT Background Physical exercise is recommended for sarcopenia prevention and treatment. Patients with frailty often show poor tolerance. To achieve universal availability, electrical stimulation of skeletal muscles...

Abstract Background Sarcopenia, altered bone and systemic metabolism, physical frailty and cognitive decline are age-dependent and interrelated phenomena. Sleep disorders which are erroneously considered as part of the a...