Buscar recursos académicos

Resumen: La enfermedad de Alzheimer es actualmente la principal causa de demencia en los adultos mayores. De hecho, esta enfermedad neurodegenerativa multifactorial representa aproximadamente entre el 60% y el 70% de tod...

Periodontitis is the most common condition of chronic periodontal infection and inflammation in the elderly population. Periodontal disease can cause local inflammation that contributes to higher risk of systemic inflamm...

Abstract Background ADAM10 and ADAM17, members of the membrane-bound disintegrin metalloproteinase (ADAM) family, act as α-secretases in the non-amyloidogenic processing of the amyloid precursor protein. While alteratio...

Amyloids constitute a class of protein and protein fragments believed to be involved in the pathologies associated with Alzheimer’s, Parkinson’s and Creutzfeldt‐ Jakob diseases. These proteins can self‐assemble i...

Alzheimer's disease involves environmental influences and genetic and biochemical factors that lead to the build up of harmful proteins like amyloid and neurofibrillary tangles in brain. This accumulation can disturb the...

Alzheimer's disease and Type-2- Diabetes Mellitus are prevalent chronic diseases linked by likely a bi-directional relationship, this relationship is partially understood. the aim of the present study is highlighting the...

Abstract Background Triggering receptor expressed on myeloid cell-2 (TREM2) signaling promotes disease-associated microglia (DAM) and phagocytosis in neurodegenerative diseases. Traditional anti-TREM2 agonist antibodies ...

Materias / palabras clave: Alzheimer’s disease; amyloid-beta; miR-32533/CREB5 pathway; neuroinflammation; oxidative stress; therapeutic strategy

Abstract Background Alzheimer’s disease (AD) carries a high societal burden inequitably distributed across demographic groups. Using real-world electronic health record (EHR) data with accurate population identificatio...

Abstract Background Tauopathies are a group of neurodegenerative diseases, including Alzheimer’s disease (AD), characterized by progressive accumulation of pathological Tau proteins. Among the diverse Tau species, trun...

Developing effective drugs for Alzheimer’s Disease (AD) is critically limited by insufficient brain exposure. To address this, structural optimization was employed to balance physicochemical properties and enhance bloo...

Abstract Limited studies have evaluated the influence of redox-related metals on the Alzheimer´s brain. We determined 15 metals in 241 human brain samples obtained from five biobanks. We examined the levels of metals in...

Abstract High-throughput analysis of EEG data has significantly contributed to understanding neural dynamics in Alzheimer’s disease diagnosis. However, the complexity and high dimensionality of EEG signals pose challen...

Abstract Cognitive deficits are a hallmark of Alzheimer’s disease (AD), and effective treatments remain elusive. Transcranial alternating current stimulation (tACS), a non-invasive technique, has shown potential in imp...

Abstract Neuroinflammation is a pathological feature of neurodegenerative diseases like Alzheimer’s disease and ALS. Cytoplasmic dsRNA (cdsRNA) triggers a type-I interferon response in human neural cells, leading to th...

Abstract In recent times, both in vitro and in vivo studies have demonstrated toxicological and pathological evidence of microplastic exposure in neurological dysfunction and diseases. The mechanistic linkage of micropla...

Background: Lymphovenous anastomosis (LVA) has recently emerged as a potential method for the symptomatic management of Alzheimer’s disease (AD). Building on this, we conceptualize the "dynamic neck LVA" (Dn-LVA) to il...

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of revising the 1984 criteria for Alzheimer's disease (AD) dementia. The workgroup sought to ensure that the revised crite...

The National Institute on Aging and the Alzheimer's Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer's disease (AD), referred to in this article as m...

Clinical criteria for the diagnosis of Alzheimer's disease include insidious onset and progressive impairment of memory and other cognitive functions. There are no motor, sensory, or coordination deficits early in the di...

The apolipoprotein E type 4 allele (APOE-epsilon 4) is genetically associated with the common late onset familial and sporadic forms of Alzheimer's disease (AD). Risk for AD increased from 20% to 90% and mean age at onse...

Materias / palabras clave: alzheimer's disease, memory loss, long-term care, caregiving, psychosocial research, dementia; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry

Materias / palabras clave: alzheimer's disease, dementia, memory disorders, dementia risk factors, neurodegenerative diseases; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous s...

Materias / palabras clave: neurosciences, clinical neurology, alzheimer's disease, gerosciences, mental health, psychiatry; Medicine: Public aspects of medicine; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: N...