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118 resultados encontrados.

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Molecular mechanism targeting condensin for chromosome condensation
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Molecular mechanism targeting condensin for chromosome condensation
Menglu Wang et al · Springer Nature · 2024 · ISSN 1460-2075
Abstract Genomes are organised into DNA loops by the Structural Maintenance of Chromosomes (SMC) proteins. SMCs establish functional chromosomal sub-domains for DNA repair, gene expression and chromosome segregation, but...
LCC LCC:Biology (General); TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Nutritional and regional assessment of wild anardana (Punica granatum L.) genotypes from the Pir Panjal range with implications for genetic resource utilization
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Nutritional and regional assessment of wild anardana (Punica granatum L.) genotypes from the Pir Panjal range with implications for genetic resource utilization
Parshant Bakshi et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Anardana, the dried arils of Punica granatum L., possesses notable culinary, nutraceutical, and medicinal value due to its richness in bioactive compounds. However, wild populations from the Himalayan belts rema...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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On-Demand Personalized Gene Editing to Treat IRF4 p.T95A Immunodeficiency
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On-Demand Personalized Gene Editing to Treat IRF4 p.T95A Immunodeficiency
Vasil Toskov et al · Rockefeller University Press · 2026 · ISSN 3065-8993
BackgroundOn-demand gene editing of autologous cells offers a novel therapeutic option for inborn errors of immunity (IEIs) caused by dominant-negative variants, which are often poorly addressed by conventional viral gen...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Prognostic value and therapeutic potential of the cuproptosis-related gene LOXL2 in thyroid cancer
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Prognostic value and therapeutic potential of the cuproptosis-related gene LOXL2 in thyroid cancer
Yu Liu et al · Elsevier · 2026 · ISSN 1936-5233
Background: Cuproptosis, a copper-dependent form of programmed cell death, has been implicated in the progression of various cancers. However, the role of LOXL2 - a cuproptosis-related gene (CRG) - and its prognostic val...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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The Hao-Fountain Syndrome Gene USP7 Restricts Neurotropic Orthoflavivirus Entry via Intrinsic Antiviral Activity
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The Hao-Fountain Syndrome Gene USP7 Restricts Neurotropic Orthoflavivirus Entry via Intrinsic Antiviral Activity
Boris Bonaventure et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Inborn errors of immunity (IEI) can manifest with neurological disorders, indicating genetic overlap between immune and nervous system diseases. However, neurological disorder genes are rarely screened systematically for...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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The genetic landscape of breast cancer in young women from Morocco: implications for diagnosis and treatment
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The genetic landscape of breast cancer in young women from Morocco: implications for diagnosis and treatment
Brahim El Hejjioui et al · BMC · 2026 · ISSN 1755-8794
Abstract Mortality rates from breast cancer in young women have fallen considerably in high-income countries but continue to rise in low-income countries such as Morocco. Young women with breast cancer face unique challe...
LCC LCC:Internal medicine; LCC:GeneticsIdioma eng
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Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes
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Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes
Nada S. Aboelella et al · Nature Publishing Group · 2026 · ISSN 2059-3635
Abstract Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles i...
LCC LCC:Medicine; LCC:Biology (General)Idioma eng
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Cell-type differential targeting of TLR5 and TLR7 agonists and their synergistic effect as nasal mucosal adjuvants
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Cell-type differential targeting of TLR5 and TLR7 agonists and their synergistic effect as nasal mucosal adjuvants
ZHUO Kexing et al · Editorial Office of Journal of Army Medical University · 2026 · ISSN 2097-0927
Abstract Objective To compare the differential activation characteristics of Toll-like receptor 5 (TLR5) agonist KFD and Toll-like receptor 7 (TLR7) agonist R837 on nasal epithelial cells (NECs) and bone marrow-derive...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma zho
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Pharmacological targeting of C3aR modulates mesangial matrix deposition in db/db mice
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Pharmacological targeting of C3aR modulates mesangial matrix deposition in db/db mice
Jing Zheng et al · PeerJ Inc · 2026 · ISSN 2167-8359
Complement activation significantly contributes to the progression of diabetic kidney disease (DKD). Recent studies have shown that renal levels of the complement component 3 (C3) and its receptor (C3aR) increase with di...
LCC LCC:Medicine; LCC:Biology (General)Idioma eng
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Protecting healthcare workers? Effects of a multilevel intervention targeting emotional demands
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Protecting healthcare workers? Effects of a multilevel intervention targeting emotional demands
Louise Schubert Paaske et al · BMC · 2026 · ISSN 2191-1991
Abstract Background Healthcare workers are frequently exposed to high emotional demands through encounters with patient suffering, death, worries, and aggressive reactions. Such demands have been linked to an elevated ri...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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Evaluating the feasibility, safety and efficacy of accelerated continuous theta-burst stimulation targeting the left primary motor cortex to improve social communication impairment in children with autism
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Evaluating the feasibility, safety and efficacy of accelerated continuous theta-burst stimulation targeting the left primary motor cortex to improve social communication impairment in children with autism
Lingli Zhang et al · Wiley · 2025 · ISSN 2517-729X
LCC TENDOlBzeWNoaWF0cnk~Idioma eng
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A Tuning Framework for VSG-Based Controllers Considering Frequency Stability and Control in Microgrids
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A Tuning Framework for VSG-Based Controllers Considering Frequency Stability and Control in Microgrids
Erico Gurski et al · IEEE · 2026 · ISSN 2687-7910
Microgrids have emerged as an effective solution for integrating distributed energy resources, providing operational flexibility by their ability to operate in grid-connected and islanded modes. However, the high penetra...
LCC TENDOkRpc3RyaWJ1dGlvbiBvciB0cmFuc21pc3Npb24gb2YgZWxlY3RyaWMgcG93ZXI~; TENDOlByb2R1Y3Rpb24gb2YgZWxlY3RyaWMgZW5lcmd5IG9yIHIdioma eng
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Characterisation and molecular detection of Echinococcus granulosus in Duhok Governorate
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Characterisation and molecular detection of Echinococcus granulosus in Duhok Governorate
HUSSEIN L. H. et al · Sciendo · 2026 · ISSN 1336-9083
Cystic hydatid disease, caused by Echinococcus granulosus, is a major zoonotic infection with significant public health and economic impact in endemic regions, including Iraq. This study aimed to detect the mitochondrial...
LCC TENDOk1pY3JvYmlvbG9neQ~~Idioma eng
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Knowledge mapping and bibliometric insights of scientific research on targeted protein degradation in oncology
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Knowledge mapping and bibliometric insights of scientific research on targeted protein degradation in oncology
Moutaz W. Sweileh · Springer · 2026 · ISSN 1432-1335
Abstract Background Disruption of cellular proteostasis leads to the accumulation and persistence of pathogenic proteins that drive oncogenesis. Key oncogenic and tumor suppressor proteins are frequently dysregulated in ...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Rickettsia felis (Rickettsiales: Rickettsiaceae) in Ctenocephalides felis felis (Siphonaptera: Pulicidae) in the State of São Paulo, Brazil Rickettsia felis (Rickettsiales: Rickettsiaceae) em Ctenocephalides felis felis (Siphonaptera: Pulicidae) no estado de São Paulo
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Rickettsia felis (Rickettsiales: Rickettsiaceae) in Ctenocephalides felis felis (Siphonaptera: Pulicidae) in the State of São Paulo, Brazil Rickettsia felis (Rickettsiales: Rickettsiaceae) em Ctenocephalides felis felis (Siphonaptera: Pulicidae) no estado de São Paulo
M.C. Horta et al · Universidade Federal de Minas Gerais, Escola de Veterinária · 2005 · ISSN 0102-0935
Samples of 10 and 14 Ctenocephalides felis felis fleas were collected on dogs from Pedreira and Mogi das Cruzes municipalities, respectively, in the State of São Paulo, Brazil, for detection of Rickettsia spp. Individua...
LCC LCC:Animal cultureIdioma eng
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Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice
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Bivalent mRNA booster encoding virus-like particles elicits potent polyclass receptor-binding domain antibodies in pre-vaccinated mice
Chengcheng Fan et al · eLife Sciences Publications Ltd · 2026 · ISSN 2050-084X
mRNA vaccines emerged as a leading vaccine technology during the COVID-19 pandemic. However, their sustained protective efficacies were limited by relatively short-lived antibody responses and the emergence of SARS-CoV-2...
LCC LCC:Medicine; TENDOlNjaWVuY2U~; LCC:Biology (General)Idioma eng
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A Novel Immunomodulatory Strategy to Control Multiple Immune Dysregulation Disorders in a Pediatric Patient
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A Novel Immunomodulatory Strategy to Control Multiple Immune Dysregulation Disorders in a Pediatric Patient
Jennifer D. Blackwood et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Immune dysregulation can lead to autoimmunity and autoinflammation. The goal of treatment is to balance targeted therapies while avoiding infections or other side effects, which becomes complicated with multiple diagnose...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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ATP2C2–PLA2R1 axis underlies lipid metabolism modulation and invasion in papillary thyroid carcinoma mediated by a VGIC signature
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ATP2C2–PLA2R1 axis underlies lipid metabolism modulation and invasion in papillary thyroid carcinoma mediated by a VGIC signature
Linlin Sun et al · Springer · 2026 · ISSN 2730-6011
Abstract Objective Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with rising incidence globally. Current prognostic markers often lack precision for individualized management. This study develo...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Agricultural input subsidies for improving productivity, farm income, consumer welfare and wider growth in low‐ and lower‐middle‐income countries: a systematic review
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Agricultural input subsidies for improving productivity, farm income, consumer welfare and wider growth in low‐ and lower‐middle‐income countries: a systematic review
David J. Hemming et al · SAGE Publishing · 2018 · ISSN 1891-1803
This Campbell systematic review examines the effects of input subsidies on agricultural productivity, beneficiary incomes and welfare, consumer welfare and wider economic growth. The review summarizes evidence from 15 ex...
LCC TENDOlNvY2lhbCBTY2llbmNlcw~~Idioma eng
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Cdk5 modulates orofacial pain through P2X2/3 purinergic receptor-mediated signaling in trigeminal neurons
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Cdk5 modulates orofacial pain through P2X2/3 purinergic receptor-mediated signaling in trigeminal neurons
Rodrigo Sandoval et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
IntroductionCyclin-dependent kinase 5 (Cdk5) plays a critical role in pain transmission by phosphorylating key nociceptive proteins. One of its recently identified substrates, the P2X2 subunit, is part of the P2X2/3 puri...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Decoding FGFR inhibitor sensitivity in cholangiocarcinoma with interpretable machine learning and cross-platform pharmacogenomic validation
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Decoding FGFR inhibitor sensitivity in cholangiocarcinoma with interpretable machine learning and cross-platform pharmacogenomic validation
Yading Xie et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
BackgroundFibroblast growth factor receptor (FGFR) inhibitors (FGFRis) benefit selected cholangiocarcinoma (CHOL) patients, yet responses remain heterogeneous and are not fully explained by canonical FGFR alterations. Cl...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Design and evaluation of a bone-anchored, neurally-controlled knee prosthesis
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Design and evaluation of a bone-anchored, neurally-controlled knee prosthesis
John A. McCullough et al · BMC · 2026 · ISSN 1743-0003
Abstract Background Commercially-available microprocessor-controlled prosthetic knees are unable to fully replicate the biomechanical function of the missing biological limb. While powered prostheses have the capacity to...
LCC LCC:Neurosciences. Biological psychiatry. NeuropsychiatryIdioma eng
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Detection and molecular characterization of Cryptosporidium spp. in captive canaries (Serinus canaria) using different diagnostic methods
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Detection and molecular characterization of Cryptosporidium spp. in captive canaries (Serinus canaria) using different diagnostic methods
Vinícius da Silva Camargo et al · Colégio Brasileiro de Parasitologia Veterinária · 2018 · ISSN 1984-2961
Abstract This study used several diagnostic methods to examine the occurrence of and molecularly characterize Cryptosporidium spp. in captive canaries (Serinus canaria) in southern and southeastern Brazil. A total of 498...
LCC LCC:Animal cultureIdioma eng
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Diet and physical activity for the prevention of noncommunicable diseases in low- and middle-income countries: a systematic policy review.
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Diet and physical activity for the prevention of noncommunicable diseases in low- and middle-income countries: a systematic policy review.
Carl Lachat et al · Public Library of Science (PLoS) · 2013 · ISSN 1549-1277
BackgroundDiet-related noncommunicable diseases (NCDs) are increasing rapidly in low- and middle-income countries (LMICs) and constitute a leading cause of mortality. Although a call for global action has been resonating...
LCC LCC:MedicineIdioma eng
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