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Abstract Androgen receptor (AR) is a therapeutic target for prostate cancer. Despite effectively targeting its folded ligand-binding domain (LBD), resistance ultimately develops by mechanisms involving reactivation of AR...

Abstract Background Thoracic surgery involves complex diseases and critically ill patients, demanding doctors to integrate solid theoretical knowledge with practical skills. Clinical medical students, however, often stru...

The article examines the effectiveness of the Maritime Security Architecture (MSA) in the Western Indian Ocean Region (WIOR), focusing on how well it addresses traditional, non-traditional, and emerging maritime threats....

El artículo presente explica por qué Kierkegaard afirma que los pensadores modernos se equivocan cuando comprenden su propia filosofía como una filosofía cristiana. El principal problema del pensamiento moderno es qu...

Abstract Introduction Enterovirus A71 (EV71)–associated encephalitis lacks targeted neuroprotective therapy. Experimental data implicate endoplasmic reticulum (ER) stress and ferroptosis in neuronal injury. We tested w...

Background: Despite the importance of investigating the effect of night shifts on the gait kinematics of nurses, the literature lacks sufficient evidence to evaluate this relationship. Therefore, the present study aimed ...

Abstract Machine-generated music (MGM) has become a groundbreaking innovation with wide-ranging applications, such as music therapy, personalised editing, and creative inspiration within the music industry. However, the ...

Artificial Intelligence (AI) is playing an increasingly pivotal role in driving innovation and promoting sustainable development across various sectors amid the ongoing wave of industrial revolutions. However, the existi...

The floral nectary of Bertholletia excelsa was studied through permanent, histological cross-sections. The flower showed two rings of androecial vascular bundles, the inner for the fertile stamens and the outer for the a...

Objective: Lidocaine needs to be administered frequently as it has poor oral bioavailability and it lacks prolong duration of action thus the study was aimed at to devise, develop, and analyze a matrix system transdermal...

Abstract It is often claimed that the theory of function levels proposed by Frege in Grundgesetze der Arithmetik anticipates the hierarchy of types that underlies Church’s simple theory of types. This claim roughly sta...

Abstract Tuberculosis (TB) remains a major global public health challenge, with drug-resistant tuberculosis (DR-TB) presenting a serious threat to TB management. Conventional treatment faces challenges such as significan...

BackgroundGATA2 deficiency results from heterozygous pathogenic variants in the GATA2 gene, which encodes a zinc-finger transcription factor essential for hematopoietic stem and progenitor cell development. It is a highl...

Oligodendrocytes (OLG) are the cells resident in the CNS responsible for myelination. OLG undergo a succession of morphological and molecular changes along several maturational stages. Galectin-3 (Gal-3) is a 25- to 35-K...

Abstract The digital business environment has become a focal point of global competition. As the world’s second-largest economy, China’s digital economy has a huge scale, and its exploration of institutional innovati...

To ensure the perennity of natural resources, the valorisation process of herbal pharmaceuticals must be assessed for sustainability from the very beginning of its design. No specific tools have been developed for this p...

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), the most prevalent cause of chronic liver disease worldwide, currently lacks precision medicine treatments. SLCO4C1 acts as a transporter for end...

In the zebra finch (Taeniopygia guttata) a germline-restricted chromosome (GRC) is regularly present in males and females. While the GRC is euchromatic in oocytes, in spermatocytes this chromosome is cytologically seen a...

Three stages can be distinguished in the history of the printed text of Iacobus Publicius’s Ars memorativa. The first one comprises two volumes published in Toulouse and Paris, around 1477. The same stage in the compos...

Introduction Hyperlipidemia serves as a significant risk factor for cardiovascular diseases and cognitive impairment, making early intervention and management highly necessary. Infrared moxibustion, a modern complementar...

This study examines the legal status and implications of Bitcoin ownership as a medium of exchange within Indonesia's evolving digital financial system. In light of persistent regulatory ambiguity, the research seeks to ...

Abstrak Penelitian ini menganalisis ketidaklengkapan norma dalam Undang-Undang Nomor 2 Tahun 2014 tentang Jabatan Notaris (UUJN) terkait ketiadaan pengaturan eksplisit mengenai kewenangan notaris dalam penyimpanan ser...

Abstract Diminished ovarian reserve (DOR) lacks strong plasma biomarkers, and recent studies have implicated lipid remodeling in its pathophysiology. In our previous study, we noted elevated circulating levels of semapho...

Intelligent mining area detection is fundamental for ecological monitoring and sustainable development of mining areas. However, current remote sensing detection lacks high-quality multimineral rotated object detection d...