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Periodontitis, a chronic inflammatory disease induced by pathogenic microorganisms. Effective management requires the elimination of plaque biofilms, the suppression of oxidative stress, and the regeneration of periodont...

Introduction: Diabetic Neuropathy (DN) is a common and debilitating complication of Diabetes Mellitus (DM), involving the sensory, motor, and autonomic nervous systems, with limited disease-modifying treatment options. E...

Metformin hydrochloride (MH), an important drug in the treatment of type II diabetes mellitus, requires multiple administration in 500-1500 mg doses/day. Sustained release gastro retentive multiparticulates of MH were pr...

La hipótesis de este trabajo de tesis es que tanto in vitro como in vivo, el tratamiento con Metformina podría proteger y/o bloquear los efectos deletéreos de los AGEs sobre el hueso. Objetivos Generales Investigar...

Se compararon los perfiles de disolución de las tabletas de Metformina 500 mg de producción cubana y de Glucophage® (Laboratorios Bristol-Myers Squibb Co.), para demostrar su similitud. También se realizó la compa...

The present study was designed to study the in vitro interaction of ketotifen fumarate and metformin hydrochloride in aqueous media at different pH values using Job’s continuous-variation analysis and Ardon’s spectro...

BACKGROUND: Type 2 diabetes affects approximately 8 percent of adults in the United States. Some risk factors--elevated plasma glucose concentrations in the fasting state and after an oral glucose load, overweight, and a...

Abstract Background Autologous fat transplantation (AFT) is widely used in aesthetic and reconstructive surgery, but its long-term outcomes remain unpredictable because of complications such as oil cyst formation, the un...

Abstract Background Polycystic ovary syndrome (PCOS) is characterised by insulin resistance and hyperandrogenism; whether novel antidiabetic drugs differentially improve these metabolic and reproductive disturbances rema...

Abstract Background Diabetes is a major global public health burden. Effective diabetes management is highly dependent on the availability of affordable and quality-assured essential medicines (EMs) which is a challenge ...

Abstract Purpose To critically evaluate evidence supporting the angiogenesis-inflammation hypothesis in diabetic retinopathy (DR); to examine the roles of angiogenic growth factors and inflammatory cytokines in the bipha...

BackgroundPathogenic variants in melanocortin-4 receptor (MC4R) are the most common cause of nonsyndromic monogenic obesity. However, links between MC4R-related obesity and pubertal tempo, and the long-term endocrine–m...

Abstract Given the multifactorial nature of diabetes and limitations of conventional monotherapies, combination therapies involving natural bioactive compounds offer a complementary strategy for more effective management...

Cortisol, is a steroid hormone, that plays a role as a stress hormone and is known to elevate blood sugar levels, leading to hyperglycemia. Hyperglycemia is characterized by high cortisol levels and insulin resistance in...

ObjectiveTo investigate the impact of blood glucose control levels on cardiac function recovery and long-term prognosis in elderly patients with acute myocardial infarction (AMI) undergoing percutaneous coronary interven...

ABSTRACT Aims To describe renal function‐specific prescribing patterns of antidiabetic drugs in Japanese patients with type 2 diabetes using real‐world data and to identify selection trends up to the second therapy. ...

Abstract This study evaluated the effects of milk fermented with Pediococcus acidilactici strain BE and Pediococcus pentosaceus strain M103 on diabetes in rats (Rattus norvegicus). The bacteria were separately used as st...

Two anatomically and functionally distinct populations of periodontium-derived fibroblasts can be identified: gingiva fibroblasts (GFs), which originate from the soft connective tissue of the gingiva and support epitheli...

Background: Hyperglycemia, characterized by elevated blood glucose levels, leads to oxidative stress and pancreatic β-cell dysfunction. Streptozotocin (STZ)-induced hyperglycemia in mice is widely used to model pancreat...

Abstract Background Diabetes is associated with a high incidence of diabetic foot and peripheral artery disease and with markedly increased lifetime amputation risk. Here we investigated predictors of reamputation risk a...

BackgroundMaturity-onset diabetes of the young (MODY) is a rare monogenic diabetes with significant renal risk, especially when combined with hyperglycemia, obesity, and other factors. While chronic cannabis use may furt...

Type 2 diabetes mellitus (T2DM) is characterized by chronic metabolic dysfunction and low-grade inflammation. This study aimed to identify inflammation-associated molecular targets in T2DM and to computationally evaluate...

The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet...

Materias / palabras clave: Medicine; Insulin; Diabetes mellitus; Internal medicine; Type 2 diabetes; Metformin; Endocrinology