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Peptide lipidation is widely employed to enhance the apparent biological performance of peptide-based systems by improving stability, membrane association, and systemic persistence. However, increased potency is often in...

This study reports the use of single-cell RNA sequencing to evaluate B cells in the peripheral blood mononuclear cells (PBMCs) and intrathyroidal blood mononuclear cells of patients with Graves’ disease (GD) undergoing...

Business competition in this fast-paced information age has become very tight. especially in the field of education. Thus the organization must have a business strategy that is very mature in order to face the competitio...

Citra Van Titipan Kilat (TIKI) merupakan perusahaan yang bergerak di bidang jasa pengiriman barang. Dikarenakan semakin berkembangnya SI/TI, kemudian ditambah juga meningkatnya persaingan dengan munculnya perusahaan jasa...

Previously we established a family of macrocyclic peptide triazoles (cPTs) that inactivate the Env protein complex of HIV-1, and identified the pharmacophore that engages Env’s receptor binding pocket. Here, we examine...

O objetivo do trabalho foi o de relacionar e discutir os hábitos e as formas de uso mais comuns das pimentas do gênero Capsicum cultivadas em Roraima, e utilizadas pelos povos indígenas e comunidades migrantes de outr...

TRPM2 is a calcium-permeable cation channel that functions as an oxidative stress sensor and plays a key role in various pathologies, particularly ischemic stroke. The activation of hsTRPM2 requires cooperative engagemen...

A crude extract rich in plant cysteine peptidases was obtained from the latex of the fruits of Araujia hortorum, a South American climbing plant. The highly concentrated extract was immobilized onto titanium dioxide to p...

Abstract In this study, a antioxidant activity peptide fraction was separated and purified from metabolites of whey protein fermented by Lactobacillus rhamnosus B2-1. The fermentation sample was separated by macroporous ...

Abstract Recently, interest in food-derived bioactive peptides as promising ingredients for the prevention and improvement of hypertension is increasing. The purpose of this study was to determine the structure and antih...

Abstract This study was conducted to compare and analyze the changes in the biochemical characteristics and biological activity of peptide extracts derived from Chickso, Hanwoo, and Wagyu beef during digestion. The resul...

Abstract Antimicrobial peptides (AMPs) are a diverse class of short peptides with therapeutic potential as antimicrobial agents and immune regulators. Many anurans (frogs and toads) produce diverse sets of AMPs via speci...

This study aimed to evaluate the impact of fruit maturity stage, storage container type, and storage duration on the content of active compounds and vitamins in hot pepper fruits (Capsicum frutescens L.), as these are im...

The relentless pursuit of athletic excellence is shadowed by the equally persistent evolution of performance-enhancing drugs (PEDs). In recent years, the antidoping landscape has been profoundly shaped by the rise of two...

Antimicrobial resistance represents a major global health challenge, particularly in the context of multidrug-resistant bacteria. Although conventional antibiotics and antimicrobial peptides (AMPs) both exert selective p...

There is a wealth of structural data on peptides that bind potential drug targets, serving as rich inspiration for designing small molecule inhibitors which can recapitulate key binding interactions while improving pharm...

ABSTRACT The results of the present study revealed significant effect of al-coholic extracts of the leaves of Teucrium polium; the fruits of Citrus aurantifolia and Capsicum annum at the concentrations 5, 10, 15, 20, 25 ...

Abstract Accumulation of amyloid beta 1–42 (Aβ42) peptide in the extracellular space in the brain is a major observation in Alzheimer’s Disease (AD)-related pathology. Astrocytes are known to play pivotal role in cl...

Surface adhesion is critical to the survival of pathogenic bacteria both in natural niches and during infections, often via forming matrix-embedded communities called biofilms. Vibrio cholerae, the causal agent of pandem...

The purpose of this work is, first, to present a fast and accurate technique to compute Boltzmann-averaged values of the quantum-chemical 13C chemical shifts for each amino acid in oligopeptides, demonstrated here by an ...

Cayenne pepper contains capsaicin, which exhibits properties that promote hair growth. Microemulsion is an oil and water dispersion system with a particle size of 10-200 nm which can be used topically as a drug delivery ...

Rational protein design has successfully enhanced the mechanical stability of biomaterials by optimizing the internal topology of force-bearing domains. However, current design strategies predominantly focus on isolated ...

With the advancement of personalized cancer immunotherapies, new tools are needed to identify tumor antigens and evaluate T-cell responses in model systems, specifically those that exhibit clinically relevant tumor progr...

X-linked severe combined immunodeficiency (SCID-X1) presents as T-B+NK- SCID, due to mutations in the common γ chain (IL2RG/CD132), a shared component of several cytokine receptors. Without definitive therapy, SCID-X1 i...