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110 resultados encontrados.

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Neutrophil extracellular traps in the tumor microenvironment, metastasis, therapy, and beyond: advances, challenges, and perspectives
Artículo
Acceso abierto Artículo DOAJ
Neutrophil extracellular traps in the tumor microenvironment, metastasis, therapy, and beyond: advances, challenges, and perspectives
Jingwen He et al · BMC · 2026 · ISSN 1756-8722
Abstract Neutrophil extracellular traps (NETs), the DNA-protein structures released by neutrophils within the tumor microenvironment (TME), play a role in cancer that extends far beyond their traditional antimicrobial fu...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBibG9vZCBhbmQgYmxvb2QtZm9ybWluZyBvcmdhbnM~; TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHIdioma eng
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Optimizing next-generation CAR-macrophages against solid tumors: challenges and potential strategies
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Optimizing next-generation CAR-macrophages against solid tumors: challenges and potential strategies
Yizhao Chen et al · BMC · 2026 · ISSN 1756-8722
Abstract Chimeric antigen receptor macrophage (CAR-M) therapy has emerged as a highly promising novel platform in solid tumor immunotherapy. Leveraging its inherent tumor-homing capacity, potent phagocytic function, and ...
LCC TENDOkRpc2Vhc2VzIG9mIHRoZSBibG9vZCBhbmQgYmxvb2QtZm9ybWluZyBvcmdhbnM~; TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHIdioma eng
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Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic
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Orchestration of the tumor microenvironment by citrus flavonoids: from preclinical mechanisms to translational therapeutic
Siyao Ma et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Malignant lung tumors are the leading cause of cancer-related mortality worldwide, and therefore remodeling of the tumor microenvironment (TME) has become an important strategy to overcome anti-tumor therapy resistance i...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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PRMT3 in cancer: arginine methylation as a driver of tumor metabolism, immune evasion, and therapeutic resistance
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PRMT3 in cancer: arginine methylation as a driver of tumor metabolism, immune evasion, and therapeutic resistance
Hui Jin et al · Frontiers Media S.A · 2026 · ISSN 1664-3224
Protein arginine methyltransferase 3 (PRMT3) is a type I arginine methyltransferase that catalyzes asymmetric dimethylation of arginine residues on diverse substrate proteins. Initially characterized as a regulator of ri...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Pleiotropic effects of BET inhibition broadly boost tumor immunogenicity to CD8+ T cells
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Pleiotropic effects of BET inhibition broadly boost tumor immunogenicity to CD8+ T cells
Jeroen Melief et al · Taylor & Francis Group · 2026 · ISSN 2162-402X
BET inhibitors (BETi) have shown potential to augment tumor immunogenicity in melanoma. However, conflicting evidence exists regarding their precise mechanism of action, and their overall impact on melanoma immunogenicit...
LCC LCC:Immunologic diseases. Allergy; TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbIdioma eng
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Profile of Primary Brain Tumor Patients Who Received Radiotherapy at Hasan Sadikin General Hospital Bandung in 2020-2021
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Profile of Primary Brain Tumor Patients Who Received Radiotherapy at Hasan Sadikin General Hospital Bandung in 2020-2021
Siti Fira Rahmawaty et al · Dharmais Cancer Hospital - National Cancer Center · 2024 · ISSN 1978-3744
Background: A brain tumor is a tumor that is most known for its dangerous progressivity. Brain tumor is classified into primary and metastatic types. One of the management for primary brain tumors is radiotherapy. This s...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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Prognostic factors and surgical approach selection for descending duodenal gastrointestinal stromal tumors
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Prognostic factors and surgical approach selection for descending duodenal gastrointestinal stromal tumors
Xiaohan Lin et al · Shanghai Chinese Clinical Medicine Press Co., Ltd · 2026 · ISSN 1008-6358
ObjectiveTo explore the prognostic factors for patients with descending duodenum gastrointestinal stromal tumors (GIST), analyze the impact of different surgical approaches on prognosis, and develop a predictive model fo...
LCC LCC:MedicineIdioma eng
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Reciprocal interactions between tumor and endothelial cells: Effects of selective vasopressin V2 receptor peptide agonists
Artículo
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Reciprocal interactions between tumor and endothelial cells: Effects of selective vasopressin V2 receptor peptide agonists
Garona, Juan et al · Smart Science & Technology · 2014 · ISSN 2331-091X
Recent experimental evidence suggested that the synthetic peptide desmopressin (DDAVP) interferes tumor angiogenesis by inducing the formation of angiostatin. It is also known that DDAVP stimulates the endothelial releas...
Idioma eng
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Research progress on the prevention and treatment of drug-induced myocardial injury related to anti-tumor therapy with Chinese traditional medicine
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Research progress on the prevention and treatment of drug-induced myocardial injury related to anti-tumor therapy with Chinese traditional medicine
Yanan Gu et al · Shanghai Chinese Clinical Medicine Press Co., Ltd · 2026 · ISSN 1008-6358
With the widespread application of chemotherapy, immunotherapy, and targeted therapy, cardiotoxicity associated with anti-tumor treatment has gained increasing attention. Drug-induced cardiac injury can significantly imp...
LCC LCC:MedicineIdioma eng
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Route-dependent dissemination with conserved blood–tumor barrier ultrastructure in intracranial metastasis models
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Route-dependent dissemination with conserved blood–tumor barrier ultrastructure in intracranial metastasis models
Jian Zhao et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract The dissemination route of brain metastases dictates their spatiotemporal distribution, but whether it alters the ultrastructural state of the blood-tumor barrier remains unresolved. Here, we compared a modified...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor
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Single-cell and spatial transcriptome analysis reveals the potential therapeutic targets for testicular sex cord-stromal cell tumor
Lei Chen et al · BMC · 2026 · ISSN 2050-7771
Abstract Testicular sex cord stromal tumor (TSCST) is a rare testicular tumor with unknown molecular mechanisms, tumor microenvironment (TME) and limited therapeutic options. To define the molecular mechanism and potenti...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Targeting tumor-associated macrophages through phytochemicals: a promising strategy for cold tumor therapy
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Targeting tumor-associated macrophages through phytochemicals: a promising strategy for cold tumor therapy
Tian Shue et al · BMC · 2026 · ISSN 1749-8546
Abstract Immunotherapy serves as the fourth modality for cancer treatment, following surgery, radiotherapy, and chemotherapy. However, its efficacy remains inconsistent due to the heterogeneity of the tumor microenvironm...
LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma eng
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The Role of COQ10B in Tumor Progression and Its Association with Immune Escape in Esophageal Squamous Cell Carcinoma: A Multi-Omics and Functional Analysis
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The Role of COQ10B in Tumor Progression and Its Association with Immune Escape in Esophageal Squamous Cell Carcinoma: A Multi-Omics and Functional Analysis
Cao L et al · Dove Medical Press · 2026 · ISSN 1178-7074
Leiyu Cao,* Xingfang Wei,* Yu Wei, Xiaoli Ma, Yan Gao, Chengcheng Qu, Wen Yi, Kalima Muhetaer, Li Zhang Cadre Healthcare Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinji...
LCC TENDOk1lZGljaW5lIChHZW5lcmFsKQ~~Idioma eng
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The double-edged sword role of tumor-associated macrophages: preventing or causing resistance to immunotherapy
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The double-edged sword role of tumor-associated macrophages: preventing or causing resistance to immunotherapy
Raheleh Roudi et al · BMC · 2026 · ISSN 1756-9966
Abstract Immunotherapy has transformed cancer treatment, yet only a subset of patients achieves durable responses. Although macrophages play a key role in modulating immune response and could be used to enhance immunothe...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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The immunological effect of hyaluronan in tumor angiogenesis
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The immunological effect of hyaluronan in tumor angiogenesis
Spinelli, Fiorella Mercedes et al · Springer Nature · 2015 · ISSN 2050-0068
The relationship between the immune system and angiogenesis has been described in several contexts, both in physiological and pathological conditions, as pregnancy and cancer. In fact, different types of immune cells, su...
Idioma eng
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The influence of brachytherapy on tooth development: a longitudinal study of pediatric head and neck tumor survivors
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The influence of brachytherapy on tooth development: a longitudinal study of pediatric head and neck tumor survivors
Guohao Zhang et al · BMC · 2026 · ISSN 1472-6831
Abstract Background Interstitial brachytherapy is an effective and organ-preserving radiotherapeutic modality for pediatric and adolescent patients with head and neck tumors, offering favorable outcomes with minimal impa...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Understanding the immunomodulatory mechanisms for natural products that overcome tumor chemoresistance to platinum-based cancer drugs and other treatments
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Understanding the immunomodulatory mechanisms for natural products that overcome tumor chemoresistance to platinum-based cancer drugs and other treatments
Yaoxuan Zhu et al · Frontiers Media S.A · 2026 · ISSN 1663-9812
RationaleCancer remains one of the most formidable challenges in mordern medicine. Chemoresistance, particularly resistance to platinum-based agents, presents a major challenge in effective treatments. In response to thi...
LCC LCC:Therapeutics. PharmacologyIdioma eng
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Unraveling Tumor Heterogeneity: Quantitative Insights from Single-cell RNA Sequencing Analysis in Breast Cancer Subtypes
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Unraveling Tumor Heterogeneity: Quantitative Insights from Single-cell RNA Sequencing Analysis in Breast Cancer Subtypes
Senra, Daniela et al · Cognizant Communication Corp · 2025 · ISSN 1052-2166
Background and objectives: Tumors are complex systems characterized by variations across genetic, transcriptomic, phenotypic, and microenvironmental levels. This study introduced a novel framework for quantifying cancer ...
Idioma eng
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VISTA promotes ovarian cancer progression through activation of NF-κB pathway and tumor microenvironment reprogramming
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VISTA promotes ovarian cancer progression through activation of NF-κB pathway and tumor microenvironment reprogramming
Sicong Liu et al · BMC · 2026 · ISSN 1757-2215
Abstract Background V-domain immunoglobulin suppressor of T-cell activation (VISTA), an immune checkpoint protein, is overexpressed in multiple cancers. However, its mechanistic role in ovarian cancer (OC) remains largel...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Visceral and subcutaneous adipose stem cells modulate colorectal cancer cell progression: direct and indirect contact distinctly accelerate tumor aggressiveness
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Visceral and subcutaneous adipose stem cells modulate colorectal cancer cell progression: direct and indirect contact distinctly accelerate tumor aggressiveness
Mikołaj Domagalski et al · BMC · 2026 · ISSN 1528-3658
Abstract Background Adipose tissue is increasingly recognized as an important component of the tumor microenvironment of colorectal cancer (CRC) and actively contributes to the progression of the disease. Adipose stem ce...
LCC LCC:Therapeutics. Pharmacology; TENDOkJpb2NoZW1pc3RyeQ~~Idioma eng
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Wound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate
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Wound formation, wound size, and progression of wound healing after intratumoral treatment of mast cell tumors in dogs with tigilanol tiglate
Paul Reddell et al · Oxford University Press · 2021 · ISSN 0891-6640
Abstract Background Tigilanol tiglate (TT) is a novel small molecule for intratumoral treatment of nonmetastatic mast cell tumors (MCTs) in dogs. In a randomized controlled clinical study, 75% of dogs that received a sin...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Additive anti-tumor and immunomodulatory effects of Sporoderm-removed Ganoderma lucidum spore powder and anti-PD-L1 antibody in lung cancer mice
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Additive anti-tumor and immunomodulatory effects of Sporoderm-removed Ganoderma lucidum spore powder and anti-PD-L1 antibody in lung cancer mice
Qiong Wang et al · Springer · 2026 · ISSN 2730-6011
Abstract Background The therapeutic efficacy of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Pow...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~Idioma eng
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An ontogeny-cytokine code determines macrophage response polarity and tumor outcomes
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An ontogeny-cytokine code determines macrophage response polarity and tumor outcomes
Dominik J. Schaer et al · Nature Portfolio · 2026 · ISSN 2399-3642
Abstract Tumor-associated macrophages can either promote or suppress cancer, but therapeutic targeting remains challenging because we lack a predictive framework for macrophage function. The prevailing M1/M2 paradigm ove...
LCC LCC:Biology (General)Idioma eng
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Correlação entre o exame clínico, a mamografia e a ultra-sonografia com o exame anatomopatológico na determinação do tamanho tumoral no câncer de mama Correlation between clinical examination, mammography and ultrasonography with histopathological exam in the determination of tumor size in breast cancer
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Correlação entre o exame clínico, a mamografia e a ultra-sonografia com o exame anatomopatológico na determinação do tamanho tumoral no câncer de mama Correlation between clinical examination, mammography and ultrasonography with histopathological exam in the determination of tumor size in breast cancer
Fernanda Monteiro de Paula Siqueira et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2008 · ISSN 0100-7203
OBJETIVO: avaliar qual o melhor método entre o exame clínico (EC), a mamografia (MMG) e a ultra-sonografia (US) na determinação pré-operatória do tamanho tumoral no câncer de mama, tendo como referência o exame a...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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