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Lung fibrosis is a severe disease with limited therapeutic options. The vascular niche is critical for lung function and fibrotic diseases, but the mechanisms by which endothelial cells (ECs) are regulated during lung in...

Abstract Background Ephrin-A4 (EFNA4), a member of the ephrin ligand family, is known to be involved in the progression of various malignant neoplasms. Nonetheless, its specific functional implications in gastric cancer ...

Abstract The vortex-induced vibration (VIV) characteristics of a long-span twin continuous steel box girder bridge under varying wind angles of attack (α m ), Scruton numbers (Sc), heights of beam (D = 0.078 m, 0.108 m,...

Abstract Transcriptional master regulators drive cell fate transitions. Peroxisome proliferator-activated receptor γ (PPARγ) is the master regulator of adipogenesis, and its expression must therefore be tightly regulat...

The escalating prevalence of overweight and obesity among young and middle-aged adults constitutes a significant public health challenge. While modifying dietary behavior is accepted as a critical component of weight man...

The regulator of citrate metabolism, CitO, from Enterococcus faecalis belongs to the FCD family within the GntR superfamily. In the presence of citrate, CitO binds to cis-acting sequences located upstream of the cit prom...

ABSTRACT This study aimed to inventory the Gomphonema species community from the Lower Iguaçu River, within an area of the Parque Nacional do Iguaçu, Paraná, Brazil, providing descriptions, comments, and photomicrogra...

H2 rich gas produced from Scenedesmus almeriensis biomass residue after lipidic extraction by low temperature catalytic gasification is addressed. The pyrolysis-gasification behavior under different atmospheres (CO2/He, ...

IntroductionReceptor-interacting serine/threonine-protein kinase 1 (RIPK1), a cytosolic protein, plays an essential role in signaling pathways responsible for inflammation and programmed cell death. In humans, two main c...

Abstract Background Carotid atherosclerosis is a kind of systemic atherosclerosis in the carotid arteries. It remains one of the leading causes of ischemic stroke. However, the efficiency of treatment is insufficient. Th...

Abstract Hydrokinetic turbines are an emerging technology to supply reliable and renewable energy by harnessing kinetic energy from river or tidal flows. They are a potential alternative to current hydropower schemes tha...

Farnesyl diphosphate synthase from Geobacillus stearothermophilus (GsFPPS) is a thermophilic enzyme which belongs to the prenyltransferase family. We found that the point mutation of an amino acid located on the fifth po...

Abstract The genomic locus that encodes the Leucine-rich repeat kinase 2 (LRRK2) gene is highly pleiotropic and associated with Parkinson’s disease (PD). Coding variants associated with risk of PD act as gain of functi...

Abstract Background Telomere length (TL), a biomarker of biological aging, but its association with Alzheimer’s disease (AD) remains unclear. Methods We estimated TL in whole-genome sequencing data from 35,014 Alzheime...

Abstract Hydropower at the Ruacana station underpins Namibia’s domestic electricity supply; however, empirical evidence of how interannual climate variability influences its performance remains limited. This study quan...

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with limited targeted treatment options. Ferroptosis has emerged as a potential therapeutic vulnerability in TNBC, but its upstream regulation r...

Marine reserves (areas closed to fishing) have been advocated for the management of many species, including the rock scallop Spondylus calcifer in the northern Gulf of California (NGC), Mexico. We developed an explicit c...

AimTo clarify the molecular mechanisms through which lobetyolin (LT) modifies the gut microbiota-bile acid axis to multitarget the regulation of hyperandrogenism, insulin resistance, chronic low-grade inflammation, and e...

Against the backdrop of global supply chain restructuring and the implementation of the Regional Comprehensive Economic Partnership (RCEP), this study investigates agricultural supply chain resilience between China and 1...

Coffee is a remarkable source of bioactive compounds, including anthocyanins, proanthocyanidins, and carotenoids, with health benefits. To fully understand the biochemical and molecular regulation mechanisms behind Coffe...

X-linked severe combined immunodeficiency (SCID-X1) presents as T-B+NK- SCID, due to mutations in the common γ chain (IL2RG/CD132), a shared component of several cytokine receptors. Without definitive therapy, SCID-X1 i...

Patagonia offers several examples of local adaptation in the exotic rainbow trout Oncorhynchus mykiss. Specifically, the Valcheta Stream, characterized by hot spring headwaters and temperate lower reaches, was initially ...

The identification of suitable models for predicting daily water flow is important for planning and management of water storage in reservoirs of Argentina. Long-term prediction of water flow is crucial for regulating res...

Social media platforms are increasingly becoming resources for mental health advice and validation. This might contribute to awareness-raising and promoting healthy behaviors, but it also raises concerns due to prolifera...