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Abstract The IL-6 signalling pathway plays a significant role in the progression and development of squamous cell carcinoma (SCC). Bazedoxifene is a potent inhibitor of IL-6R; however, its efficacy is limited by its low ...

The transformations during continuous cooling and their effect on the thermoelastic behaviour of β-CuAlBe shape memory alloys have been studied by electrical resistometry, microscopy and differential calorimetry. Under ...

Abstract This study investigated the effects of pressure-mediated protein changes on the ice nucleation temperature of pork loins. To variate chemical state of meat proteins, pork loin was pressurized at varying pressure...

Nafion exhibits one of the highest proton conductivity at room temperature and it is the standard electrolyte of proton exchange membrane fuel cells (PEMFC). However, the temperature dependence of ionic conductivity of N...

Abstract Alternative protein sources with greater nutritional value and a lower environmental footprint have recently attracted interest in the production of meat substitutes. However, it is required that these alternati...

ObjectiveThe study aimed to assess the effects of resting energy expenditure (REE) on critically ill individuals requiring mechanical ventilation with different degrees of sedation.DesignA prospective self-controlled stu...

Low nano-SiO2 loaded nylon 6 (PA6) nanocomposites were readily produced via in situ polymerization. The effect of surface-modified functional groups of nano-SiO2 on the interfacial structure and properties of nylon 6/SiO...

We report here the synthesis of divalent ligands containing 3-deoxy-4-thiolactose. This thiodisaccharide has been synthesized using the Michael addition of β-1-thiogalactose to the α,β-unsaturated system of sugar-deri...

The aim of this work was to synthesize and to characterize new pH-sensitive hydrogels that can be used in the controlled release of drugs, useful for dermal treatments or ophthalmology's therapies. Copolymers containing ...

Atherosclerosis is the main cause of cardiovascular disease (CVD) characterized by fat accumulation and transformation, inflammation, smooth muscle cell proliferation, and necrotic cell remnants in the tunica intima of b...

A modified low-sensitive explosive composition (LSX) was successfully prepared in the lab. The composition was based on three main explosives: 35 % dinitroanisole (DNAN), 45 % nitrotiazolone (NTO), and 20 % 1,3,5-t...

El D-003 es un nuevo producto que consiste en una mezcla de ácidos grasos de elevado peso molecular (desde C24:0 hasta C36:0), donde cada uno de ellos está en una proporción reproducible. Este producto presenta efecto...

En el presente trabajo se estudió la descomposición térmica del efavirenz (EFZ), un no-nucleótido que es inhibidor de la transcriptasa reversa de prolongada vida media, utilizando calorimetría diferencial de barrido...

Com o objetivo de determinar os parâmetros térmicos do antiretroviral zidovudina (AZT) foram empregados a Calorimetria Exploratória Diferencial (DSC) e a Termogravimetria (TG). A curva DSC do fármaco indicou uma temp...

Hidrocolóides têm sido amplamente estudados no desenvolvimento de novos materiais voltados a aplicação em sistemas para liberação modificada de fármacos, especialmente em função das características de biodegrad...

Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to investigate drug-excipient interactions and, in consequence, their compatibility. For this purpose, binary mixtures of olanzapine ...

En estudios preliminares de la preformulación, la evaluación de interacciones en el estado sólido entre un componente activo con diversos excipientes es esencial para garantizar la calidad del producto final. Varias i...

Micropartículas de aciclovir/quitosana de liberação prolongada foram desenvolvidas pela técnica de spray-drying, apresentando uma eficiência de encapsulação em torno de 90%. Os resultados obtidos por calorimetria ...

The aim of the present study was to develop sustained release swelling tablets containing metformin HCl and confine them into the stomach for enhancement of bioavailability. The different batches were manufactured by wet...

The aim of the present investigation is to improve the dissolution of poorly water soluble drug valsartan by preparing solid dispersions and also to evaluate the effect of different inert carriers on flow properties of s...

Fenofibrate is more effective drug as compared to other fibrates. But low bioavailability of it is due to its poor aqueous solubility. The purpose of present study was to improve fenofibrate dissolution through its formu...

Metformin hydrochloride (MH), an important drug in the treatment of type II diabetes mellitus, requires multiple administration in 500-1500 mg doses/day. Sustained release gastro retentive multiparticulates of MH were pr...

Powder mixtures (1:1) of tibolone polymorphic forms I (monoclinic) and II (triclinic) and excipients have been prepared and compacted. The samples were stored at 50 °C and 90% RH for one month and subsequently were eval...

This article investigates enhancement of the dissolution profile of gliclazide, an antidiabetic drug, using the combination of solid dispersions and melt adsorption techniques. Poloxamer and PEG 6000 were utilized as hyd...