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Illegible handwritten patient records pose a significant threat to clinical accountability and legal integrity in South Africa’s healthcare system. Despite clear guidelines from the Health Professions Council of South ...

Common variable Immunodeficiency (CVID) is a heterogeneous immunodeficiency characterized by hypogammaglobulinemia and immune dysregulation. In up to 30% of cases, there is a monogenic defect, with a fraction of these fa...

IntroductionComplement C2 deficiency is a classical pathway defect associated with recurrent infections and autoimmunity. This case demonstrates the need for increased awareness amongst rheumatologists for the indication...

IntroductionThe ERCC2 gene, located on chromosome 19, is essential for transcription and DNA repair via its protein product, XPD. Mutations in ERCC2 cause disorders such as trichothiodystrophy-1, xeroderma pigmentosum, C...

Abstract Background Retroperitoneal lymphatic malformations (LMs) are rare, and their deep location adjacent to critical structures renders treatment particularly challenging. This retrospective study aims to investigate...

Abstract Background Pancreatic portal hypertension (PPH) is a distinct form of sinistral (left-sided) portal hypertension, primarily resulting from pancreatic diseases such as acute or chronic pancreatitis and pancreatic...

BackgroundRAS-associated autoimmune leukoproliferative disorder (RALD) is a rare immune-dysregulation syndrome caused by pathogenic mutations in RAS–MAPK pathway genes, most commonly KRAS. It is characterized by autoim...

Abstract Background Radiation-induced sarcoma (RIS) is a rare, fatal late complication of radiotherapy for nasopharyngeal carcinoma (NPC), particularly in the anatomically complex skull base region. Despite the high radi...

Abstract Background Preeclampsia (PE) is a major cause of maternal and fetal mortality andmorbidity. Its etiology is idiopathic, but it is known that the disease is associated with a prothrombotic state. In this context,...

Abstract Background Floods are among the most frequent and destructive natural disasters worldwide, and India remains one of the most affected countries. Post-traumatic stress disorder (PTSD) is a common and enduring psy...

Since 2020, our clinic has observed a notable increase in primary immunodeficiency (PI) patients presenting with antibody deficiencies, despite previously reporting minimal illness or being clinically stable prior to the...

Abstract Background Total prostate-specific antigen (tPSA) could be elevated in some cases of benign prostate enlargement (BPE). The aim of this study is to evaluate tPSA clearance after surgery for BPE with histologic c...

IntroductionHaploinsufficiency of A20 (HA20) is a monogenic autoinflammatory disorder caused by heterozygous loss-of-function variants in TNFAIP3, resulting in dysregulated NF-κB activation. Clinical presentations are h...

CARMIL2 is a protein required for T cell activation, specifically for CD28 and CARMA-1/PKC coupling and NF-kB signaling. CARMIL2 deficiency has pleiotropic presentations, which can include recurrent viral and mucocutaneo...

BackgroundB cell Expansion with NF-κB Activation and T cell Anergy (BENTA) disease is a rare inborn error of immunity caused by gain-of-function (GOF) variants in CARD11. It is characterized by early-onset lymphadenopat...

Starting from the relationship between urban planning and mobility management, TeMA has gradually expanded the view of the covered topics, always remaining in the groove of rigorous scientific in-depth analysis. This sec...

Measles surveillance in Côte d’Ivoire from 2010 to 2022: Epidemiology – Associated factors – recommendations. Background: In 2011, African countries planned to eliminate measles by 2020. Since this goal was not a...

X-linked inhibitor of apoptosis (XIAP) is essential for innate and adaptive immune responses, including programmed cell death inhibition, NFkB and MAPK activation, NLRP3 inflammasome activity regulation, and TNFR signali...

Abstract Background Tuberculosis remains a major public health challenge in Somalia, where a fragile health system and reliance on private providers complicate care. Although Public-Private Partnerships are globally reco...

Abstract Objectives This dataset was specifically collected to support the development and evaluation of computer-aided diagnosis (CAD) systems for breast cancer detection. The dataset, Ma’amon Diagnostic Center Mammog...

Abstract Diagnosis of upper gastrointestinal (UGI) mucosal lesions primarily uses endoscopy. Based on our preliminary work in Zambia which showed that free blood in the stomach was associated with gastric mucosal lesions...