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99 resultados encontrados.

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The inhibition of the MRN complex by Mirin radiosensitizes particularly HPV-negative HNSCC cell lines
Artículo
Material complementario disponible Artículo DOAJ
Laura S. Hildebrand et al · BMC · 2026 · ISSN 1475-2867
Abstract Background Head and neck squamous cell carcinoma (HNSCC) is a relevant cancer entity with two main risk factors. Human papilloma virus (HPV)-positive ones are induced by virus infection and generally have a good...
LCC TENDOk5lb3BsYXNtcy4gVHVtb3JzLiBPbmNvbG9neS4gSW5jbHVkaW5nIGNhbmNlciBhbmQgY2FyY2lub2dlbnM~; LCC:CytologyIdioma eng
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Usnic acid induces apoptosis and inhibits cell migration and invasion in hepatocarcinoma cells: in vitro and in silico analysis
Artículo
Material complementario disponible Artículo DOAJ
Dogukan Mutlu · BMC · 2026 · ISSN 2662-7671
Abstract Background Lichens produce several secondary metabolites with significant biological and pharmacological activities, among which usnic acid (UA) is particularly notable. This study aimed to investigate the cytot...
LCC TENDOk90aGVyIHN5c3RlbXMgb2YgbWVkaWNpbmU~Idioma eng
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Differences in heart DNA methylation between sudden infant death syndrome and other sudden deaths
Artículo
Acceso abierto Artículo DOAJ
Chad M. Aldridge et al · BMC · 2026 · ISSN 1868-7083
Abstract Background Sudden Infant Death Syndrome (SIDS) remains a leading cause of infant mortality worldwide, yet its underlying mechanisms are largely unknown. SIDS etiology is complex and involves the interplay betwee...
LCC LCC:Medicine; LCC:GeneticsIdioma eng
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Open Access
Efficacy and safety analysis of CAR-T cell salvage therapy in relapsed/refractory diffuse large B-cell lymphoma after failure of bispecific antibody treatment
Artículo
Acceso abierto Artículo DOAJ
Fuli Li et al · BMC · 2026 · ISSN 1479-5876
Abstract Background Patients with relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) who failed bispecific antibody (BsAb) therapy face an extremely poor prognosis, necessitating exploration of effective salva...
LCC LCC:MedicineIdioma eng
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Open Access
Main Complications during Pregnancy and Recommendations for Adequate Antenatal Care in Sickle Cell Disease: A Literature Review
Artículo
Acceso abierto Artículo DOAJ
Camilla Olivares Figueira et al · Federação Brasileira das Sociedades de Ginecologia e Obstetrícia · 2022 · ISSN 0100-7203
Abstract Sickle cell disease (SCD) is the most common monogenic disease worldwide, with a variable prevalence in each continent. A single nucleotide substitution leads to an amino-acid change in the β-globin chain, alte...
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Noise Exposure Potentiates Exocytosis From Cochlear Inner Hair Cells
Artículo
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Boero, Luis Ezequiel et al · Frontiers Media · 2021 · ISSN 1663-3563
Noise-induced hearing loss has gained relevance as one of the most common forms of hearing impairment. The anatomical correlates of hearing loss, principally cell damage and/or death, are relatively well-understood histo...
Idioma eng
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Orbital cellulitis as a complication of odontogenic infection
Artículo
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Puji Yuli Christiani Purba et al · faculty of dentistry universitas gadjah mada · 2019 · ISSN 2460-0164
Orbital cellulitis is uncommon sequelae of the spread of odontogenic infection to adjacent maxillary sinuses or to distant sites such as the orbits. Once it happened, the spread of such infection can be of serious compli...
LCC TENDOkRlbnRpc3RyeQ~~Idioma eng
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Open Access
Platelet-derived microparticles increase the interaction of colorectal cancer cells with the endothelium to promote metastatic events
Artículo
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Izabela Papiewska-Pająk et al · BMC · 2025 · ISSN 1479-5876
Abstract Background The major challenge in colorectal cancer (CRC) therapy involves the formation of distant metastases, which represent the primary cause of treatment failure and patient death. To undergo metastasis, ca...
LCC LCC:MedicineIdioma eng
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Open Access
Sickle Cell Vaso-Occlusive Crisis Leading to Uteroplacental Malperfusion: A Case Report
Artículo
Acceso abierto Artículo DOAJ
Annika van Oosbree et al · Thieme Medical Publishers, Inc · 2026 · ISSN 2157-6998
Background Sickle cell disease (SCD) in pregnancy is associated with substantially increased risks of stillbirth and neonatal death due to vaso-occlusive crises, chronic anemia, and impaired placental perfusion.
LCC TENDOkd5bmVjb2xvZ3kgYW5kIG9ic3RldHJpY3M~Idioma eng
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Open Access
Examining the validity of Poissonian models against the birth and death TCP model for various radiotherapy fractionation schemes
Artículo
Material complementario disponible Artículo CONICET Digital
Horas, Jorge Alberto et al · Taylor & Francis Ltd · 2010 · ISSN 0955-3002
Purpose: To compare the results obtained for tumour control probability (TCP) in protracted treatments, we used two models which apply Poisson statistics for clonogenic cell distribution and a non-Poissonian model, empha...
Idioma eng
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Expanded Clinical Spectrum of Artemis SCID: A Novel DCLRE1C c.545G>A Variant with Residual T Cell Function
Artículo
Acceso institucional disponible Artículo DOAJ
Nouf Faisal Alsaati et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Artemis-deficient severe combined immunodeficiency (SCID) is a rare autosomal recessive disorder caused by pathogenic variants in DCLRE1C, which encodes ARTEMIS, a DNA repair endonuclease essential for V(D)J recombinatio...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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Institucional
Heat-not-burn tobacco induces protein post-translational modifications and apoptosis in bronchial cells: possible role in rheumatoid arthritis
Artículo
Acceso abierto Artículo DOAJ
Roberta Priori et al · BMJ Publishing Group · 2026 · ISSN 2056-5933
Objectives Smoking is recognised as one of the strongest environmental risk factors for the development of rheumatoid arthritis (RA). Cigarette smoke increases protein post-translational modifications (PTMs), including c...
LCC LCC:MedicineIdioma eng
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Open Access
Induction of caspase-mediated suppression of interferon signaling potentiates viral oncolysis of resistant tumor cells
Artículo
Acceso abierto Artículo DOAJ
Vladimir Bozhdansky et al · BMC · 2026 · ISSN 1478-811X
Abstract Tumors and cancer cell lines exhibit varying levels of activation in interferon (IFN) pathways and expression of IFN-stimulated genes (ISGs). This heterogeneity correlates with differential susceptibility to onc...
LCC LCC:Medicine; LCC:CytologyIdioma eng
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Open Access
Inhibition of Survival Pathways MAPK and NF-kB Triggers Apoptosis in Pancreatic Ductal Adenocarcinoma Cells via Suppression of Autophagy
Artículo
Acceso abierto Artículo CONICET Digital
Papademetrio, Daniela Laura et al · Springer · 2016 · ISSN 1776-2596
Background: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with a survival rate of 4–6 months from diagnosis. PDAC is the fourth leading cause of cancer-related death in the Western world, with a mort...
Idioma eng
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Open Access
Integrated multi-omics and single-cell analysis reveals CDKN2A-mediated cuproptosis mechanisms driving thyroid carcinoma progression
Artículo
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Jukai Huang et al · Nature Portfolio · 2026 · ISSN 2056-7189
Abstract Cuproptosis is a recently identified copper-dependent cell death pathway with growing relevance in tumor biology, yet its involvement in thyroid carcinoma (TC) remains poorly understood. In this study, we integr...
LCC LCC:Biology (General)Idioma eng
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Oxya chinensis sinuosa (OC) Extracts Protects ARPE-19 Cells against Oxidative Stress via Activation of the Mitogen-Activated Protein Kinases (MAPKs)/ Nuclear Factor-κB (NF-κB) Pathway
Artículo
Acceso abierto Artículo DOAJ
Bong Sun Kim et al · Springer Nature · 2024 · ISSN 2636-0772
Abstract Oxya chinensis sinuosa (OC) is a well-known edible insect. Several researches on the health benefits of OC consumption have been performed to date; however, their effect on eye health remains largely unknown. Th...
LCC TENDOkZvb2QgcHJvY2Vzc2luZyBhbmQgbWFudWZhY3R1cmU~; LCC:Animal cultureIdioma eng
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Open Access
Synergistic effects of HDAC inhibitor tucidinostat and ENT inhibitor dipyridamole in T-cell malignancies
Artículo
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Jiazhou Li et al · Nature Portfolio · 2026 · ISSN 2045-2322
Abstract Achieving both selectivity and cytotoxicity against cancer cells remains a major challenge in cancer therapy. Histone deacetylase (HDAC) inhibitors, such as tucidinostat, suppress tumor growth by epigenetically ...
LCC LCC:Medicine; TENDOlNjaWVuY2U~Idioma eng
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Targeting dormant cancer cells: ferroptosis as a precision therapeutic strategy
Artículo
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Sijia Hao et al · BMC · 2026 · ISSN 1689-1392
Abstract Dormant cancer cells are a significant source of cancer recurrence and metastasis and exhibit robust resistance to conventional therapies. Therefore, the exploration of novel therapeutic strategies to eliminate ...
LCC LCC:CytologyIdioma eng
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Therapeutic targeting of BCL-2 during CART cell production augments potency through non-apoptotic adaptive changes
Artículo
Acceso abierto Artículo DOAJ
Nada S. Aboelella et al · Nature Publishing Group · 2026 · ISSN 2059-3635
Abstract Targeting the BCL-2 family of proteins, key regulators of cellular apoptosis, with BH3-mimetics has been a major therapeutic goal to overcome cancer cell death resistance. However, beyond their canonical roles i...
LCC LCC:Medicine; LCC:Biology (General)Idioma eng
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Effect of leukoreduction on inflammation in critically ill dogs receiving red blood cell transfusions: A randomized blinded controlled clinical trial
Artículo
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Melissa A. Claus et al · Oxford University Press · 2022 · ISSN 0891-6640
Abstract Background Prestorage leukoreduction of red blood cell (RBC) bags prevents accumulation of pro‐inflammatory mediators and experimentally attenuates post‐transfusion inflammation in healthy dogs. However, the...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Moringa oleifera Leaves Ethanol Extract Inhibits HT-29 Cells and COX-2 Expression Predictably Through PPARγ Activation
Artículo
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Aryo Tedjo et al · Universitas Gadjah Mada · 2024 · ISSN 1410-5918
Colorectal cancer is the second leading cause of death among all cancer cases worldwide. Cancer cells often exhibit overexpression of cyclooxygenase-2 (COX-2), producing prostaglandin E2 (PEG2) and subsequent inflammatio...
LCC LCC:MedicineIdioma eng
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Open Access
Oleate alters the immune response in non-small cell lung adenocarcinoma through regulation of HMGB1 release
Artículo
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Breanna Cole-Skinner et al · Frontiers Media S.A · 2024 · ISSN 2296-634X
BackgroundCancer cell evasion of the immune response is critical to cancer development and metastases. Clinicians' ability to kickstart the immune system to target these rogue cells is an ever-growing area of research an...
LCC LCC:Biology (General)Idioma eng
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Outcomes of adjunctive radiation therapy for the treatment of mast cell tumors in dogs and assessment of toxicity: A multicenter observational study of 300 dogs
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Sarah L. Mason et al · Oxford University Press · 2021 · ISSN 0891-6640
Abstract Background Radiation therapy is commonly used as an adjunct to incomplete surgical excision in dogs with mast cell tumors (MCT), but the optimal dose and fractionation regimen have yet to be determined. Hypothes...
LCC TENDOlZldGVyaW5hcnkgbWVkaWNpbmU~Idioma eng
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Prospective Clinical Trial of Mycophenolate Mofetil (MMF) Duration De-Escalation in Allogeneic Hematopoietic Cell Transplantation (HCT) for Inborn Errors of Immunity: Is MMF Dispensable After Reduced Intensity Conditioning, Posttransplantation Cyclophosphamide(Ptcy)-Based HCT?
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Dimana Dimitrova et al · Rockefeller University Press · 2026 · ISSN 3065-8993
Hematopoietic cell transplantation (HCT) offers curative potential for inborn errors of immunity (IEI) patients, who often enter HCT with significant comorbidities and disease sequelae, active infections, and/or limited ...
LCC LCC:Immunologic diseases. AllergyIdioma eng
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