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ABSTRACT Mass cytometry is optimal for acute leukemia immune checkpoint profiling. However, current commercial metal‐chelating polymer (MCP) metal tags limit its sensitivity due to low metal loading capacity. We report...

Convergent extension (CE) is a fundamental morphogenetic process where oriented cell behaviors lead to polarized extension of diverse tissues. In vertebrates, regulation of CE requires both non-canonical Wnt, its co-rece...

Background: The nature of rejection and fetal allograft survival following the host-versus-graft reactivity remains the subject of intense investigation. Pregnancy-induced hypertension, also known as pre-eclampsia, is a ...

ABSTRACT Epithelial and endothelial monolayers maintain homeostasis by adapting to physiological stimuli and injury through conversion processes that remain incompletely understood. Using human umbilical vein endothelial...

Abstract Background Apoptosis is a fundamental biological process and a central determinant of therapeutic response in breast cancer (BC). Resistance to immunotherapy is increasingly recognized to be driven, in part, by ...

Jayshree H Ahire,1 Qi Wang,2 Yongping Bao,2 Isabelle SR Storer,1,3 Stefan Bidula,1,3 Gary Rowley,3,4 Jason C Crack1 1School of Chemistry, Pharmacy and Pharmacology, University of East Anglia, Norwich, Norfolk, UK; 2Norwi...

Weiming Hao,1 Ruigao Song,1 Huimin Lv,1 Chunying Song2 1Reproductive Medicine Center, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiy...

Abstract Background Microglial activation is increasingly recognized as a critical contributor to both the initiation and chronification of migraine. Recent advances have highlighted the importance of receptor-mediated s...

Background: Hematological malignancies, encompassing leukemia, lymphoma, and myeloma, constitute a significant cause of morbidity and mortality. Early diagnosis plays a pivotal role in improving prognosis and facilitatin...

We reveal a coordinating role for Cx32-mediated cell–cell communication in maintaining mitotic-quiescence and limiting migration-associated TGFβ signalling, extracellular matrix remodelling and mesenchymal-like change...

Localization of the cell adhesion receptor E-cadherin within the furrow is associated with reduced cytokinetic fidelity. Cortical organization of formin-polymerized linear actin filaments at the division zone physically ...

In severe cases of COVID-19, glucocorticoid treatment improves clinical outcomes. However, in non-hospitalized patients, glucocorticoids have limited benefit and may impair viral clearance. Here, we used the rhesus macaq...

Abstract Nuclear pore complexes serve as essential gatekeepers of the nuclear envelope, playing crucial roles in regulating transport across the nuclear envelope and maintaining compartmentalization between the nucleus a...

Abstract Microplastics (MPs) represent a significant environmental pollutant and have raised considerable concern due to their tendency to accumulate in animals, plants, and humans, thereby posing potential health risks....