Buscar recursos académicos

Background: Periodontitis combined with orthodontic treatment creates a complex inflammatory and biomechanical microenvironment in gingival tissue, where macrophages play pivotal roles in tissue remodeling and immune reg...

Background Tranexamic acid (TXA) is widely used for pigmentary disorders, but its anti-ageing potential remains unclear. This study aimed to evaluate whether topical 3% TXA improves early periorbital wrinkles in women wi...

ABSTRACT Epithelial and endothelial monolayers maintain homeostasis by adapting to physiological stimuli and injury through conversion processes that remain incompletely understood. Using human umbilical vein endothelial...

BackgroundMyocardial ischemia/reperfusion (I/R) injury is a major challenge in reperfusion therapy for acute myocardial infarction, primarily due to excessive oxidative stress, inflammation, and cardiomyocyte apoptosis. ...

Abstract Since the first report in 1972, several studies have documented an association between Parkinson’s disease (PD) and melanoma. Up to 20-fold increased risk of melanoma was reported in PD patients, while a perso...

Antimicrobial drug resistance is a serious challenge in clinical settings worldwide, with biofilm formation having been associated with this problem. In the present study, the synergism of oligostyrylbenzene (OSB) compou...

Early adversity programs induce changes that can accelerate biological aging. Using the early stress model of maternal separation (MS), we assessed oxidative, metabolic, and biochemical consequences in serum derived from...

Ageing is a complex biological process marked by gradual functional decline, reduced cellular resilience, and increased vulnerability to chronic diseases. Maintaining cell health has become a crucial strategy for extendi...

Abstract As a hydroxymethylglutaryl‒coenzyme A reductase (HMGCR) inhibitors, atorvastatin (ATST) has garnered widespread attention because of its antitumor effects. However, its specific mechanism of action remains inc...

Abstract Early weaning or enteric pathogen exposure frequently induces intestinal epithelial oxidative stress in piglets, which disrupts redox homeostasis, impairs tight junction integrity, and ultimately compromises int...

Abstract Background Hepatic ischemia-reperfusion injury (HIRI) is a pathophysiological process during liver transplantation, characterized by insufficient oxygen supply and subsequent restoration of blood flow leading to...

Abstract Background Gas-phase bioprocesses that immobilize microbial cells on solid carriers enable efficient conversion of volatile or poorly water-soluble substrates. Acinetobacter sp. Tol 5 is a highly adhesive bacter...

Oxidative stress–induced cellular injury is a key mechanism underlying tissue dysfunction, and food-derived phenolic compounds have attracted interest as natural modulators of redox homeostasis. Sensory cells, includin...

Abstract Background Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma. Fatty acid synthase (FASN) is a key lipogenic enzyme implicated in tumor progression, but its regulation in DLBC...

Abstract Autophagy-linked organelle remodeling is essential for skeletal muscle differentiation and is closely linked to the metabolic environment. The ketone body 3-hydroxybutyrate (3HB) serves as an alternative energy ...

Introduction and aims: Human dental pulp stem cells (hDPSCs) play pivotal roles in the regeneration of pulp-dentin complex, yet their odontogenic differentiation is critically modulated by the inflammatory microenvironme...

Abstract Dormant cancer cells are a significant source of cancer recurrence and metastasis and exhibit robust resistance to conventional therapies. Therefore, the exploration of novel therapeutic strategies to eliminate ...

Background: Copper (Cu) is an essential trace metal used as a catalytic cofactor for many enzymes. However, it can have nocive effects when it participates in the Fenton reaction, producing reactive oxygen species (ROS)....

Abstract Man-made synthetic/manufactured nano-objects (MNOs) are increasingly used in almost every scientific sector, including pharmaceutical, agricultural, food, and drug industries worldwide. Rapid advances in nanotec...

Increased levels of α-synuclein (α-syn) and iron-overload are pathognomonic signs of dopaminergic neurons in Parkinson’s disease (PD) patients. Moreover, iron and fatty acid (FA) availability are predisposing factors...

Abstract Background Oxygen therapy is often lifesaving for critically ill patients with acute respiratory distress syndrome (ARDS). However, high oxygen doses may cause hyperoxic acute lung injury (HALI). In line with th...

Chronic pain is a significant global health burden often resistant to conventional analgesics. Evidence implicates that mitochondrial dysfunction is not only a cellular consequence of injury, but also a fundamental drive...

Abstract Sirtuin 1 has an important role in cellular processes, including apoptosis and cellular stress. The purpose of this study was to assess serum sirtuin 1 levels in women with recurrent implantation failure (RIF). ...

Cu, a common essential trace element in the human body, is involved in multiple physiological and pathological processes. Cuproptosis, a recently proposed form of cell death, is triggered by Cu overload. It primarily tar...